DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sol and Capn1

DIOPT Version :9

Sequence 1:NP_476738.3 Gene:sol / 44014 FlyBaseID:FBgn0003464 Length:1594 Species:Drosophila melanogaster
Sequence 2:NP_062025.1 Gene:Capn1 / 29153 RGDID:2267 Length:713 Species:Rattus norvegicus


Alignment Length:385 Identity:127/385 - (32%)
Similarity:184/385 - (47%) Gaps:72/385 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   990 RQLEETEALTKWQNIIQY-----------CRDNSELFVDDSFPPAPKSLYY---NPASGAGEGNP 1040
            :|.::...|.:.:|.|:|           |..|..||.||:|||...||.:   .|.|....|  
  Rat    20 KQRDKELGLGRHENAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYG-- 82

  Fly  1041 VVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEIC 1105
             ::|:||.|:..:     |..:......:|||||.||:||||:|:|.|...|.::..|:.    .
  Rat    83 -IKWKRPTELLSN-----PQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVP----Y 137

  Fly  1106 GQ-------GAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVY-SQAKRKQLWVPLIEKAVAKIHGC 1162
            ||       |.:..:|.:.|:|..|:|||||| .|.|.||: ..|:..:.|..|:|||.||::|.
  Rat   138 GQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLP-TKDGKLVFVHSAQGNEFWSALLEKAYAKVNGS 201

  Fly  1163 YEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGG 1227
            ||||..|...|.....||...|...||.:    ||:       ::..:|.:.....|:|.|....
  Rat   202 YEALSGGCTSEAFEDFTGGVTEWYDLQKA----PSD-------LYQIILKALERGSLLGCSINIS 255

  Fly  1228 NMKVDEEEYQQKGLRPRHAYSVLDVKDI--QGHR--LLKLRNPWGHYSWRGDWSDDSSLWT---- 1284
            ::: |.|....|.|...|||||.|.|.:  ||.|  |:::|||||...|:|.|||:|..|.    
  Rat   256 DIR-DLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDP 319

  Fly  1285 ---DDLRDALMPHGASEGVFWISFEDVLNYFDCIDIC-------KVRS--GWNEVRLQGT 1332
               :.||..:     .:|.||:||.|.:..|..::||       |.|:  .||....:||
  Rat   320 YEREQLRVKM-----EDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGT 374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
solNP_476738.3 zf-RanBP 6..34 CDD:279035
RanBP2-type Zn finger 10..29 CDD:275376
zf-RanBP 135..164 CDD:279035
zf-RanBP 643..672 CDD:279035
RanBP2-type Zn finger 647..667 CDD:275375
zf-RanBP 704..731 CDD:279035
RanBP2-type Zn finger 708..727 CDD:275376
zf-RanBP 747..774 CDD:279035
RanBP2-type Zn finger 749..768 CDD:275376
zf-RanBP 927..954 CDD:279035
RanBP2-type Zn finger 931..950 CDD:275376
CysPc 1001..1328 CDD:128526 123/368 (33%)
Capn1NP_062025.1 Peptidase_C2 56..352 CDD:279042 112/325 (34%)
Domain III 355..525 6/20 (30%)
Calpain_III 366..518 CDD:279416 4/9 (44%)
Linker 526..541
PTZ00184 537..680 CDD:185504
Domain IV 542..712
EF-hand_8 556..609 CDD:290545
EFh 589..643 CDD:238008
EFh 622..704 CDD:298682
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0045
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D704215at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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