DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sol and Capn11

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	XP_011244781.1	Gene:	Capn11 / 268958	MGIID:	1352490	Length:	753	Species:	Mus musculus

Alignment Length:	723	Identity:	175/723 - (24%)
Similarity:	284/723 - (39%)	Gaps:	201/723 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   938 YDNCAASVV----------C---------DICSSPRGLASAVLGEALGRKSVRVALTPADIRQES 983
            ||:....||          |         ||..:.:|:.:.:....|..|.|.......:.:.::
Mouse    16 YDSTKVQVVELMGLLALSACEEFLTGAWMDISWAEKGMVATINHSRLKDKGVGQHQNAYNYKNQN 80

  Fly   984 KLMENLRQLEETEALTKWQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPH 1048
              .|:||    .|.|.|           .|||.|..||..|:|:.........|....:.|:||.
Mouse    81 --YEDLR----AECLRK-----------GELFEDPFFPAEPRSIGVKNLGPNSEHMQNIYWQRPK 128

  Fly  1049 EINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQ---GAY 1110
            :|     .:.|..:.....|:|||||:||:||||:|:..|.....|:..|:...:...:   |.:
Mouse   129 DI-----IHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRNQSFKKNYAGIF 188

  Fly  1111 QVRLCKDGKWTTVLVDDLLPCDKRGHLVYSQAKRKQ-LWVPLIEKAVAKIHGCYEALVSGRAIEG 1174
            ..:|.:.|.|..|:|||.|| .:...||:..|..:| .|..|:|||.||:.|.|.||..|..:||
Mouse   189 HFQLWQFGHWLNVVVDDRLP-TRNNKLVFVHASHRQDFWSALLEKAYAKLIGSYGALSGGSTLEG 252

  Fly  1175 LATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVR-FLMGASCG-GGNMKVDEEEYQ 1237
            |...||...:.||||     .|..:.|       :||.....: .|||.|.. ..|.:|:...:.
Mouse   253 LEDFTGGVAQCIPLQ-----KPPGNML-------RLLKKALEKSSLMGCSIEVTDNSEVETMTHN 305

  Fly  1238 QKGLRPRHAYSVLDVKDI----QGHRLLKLRNPWGHYSWRGDWSDDSSLWTD---DLRDALMPHG 1295
            .  |...|||:|..::|:    :...|::::||||...|.|.|||.::.|.:   |:|..|: |.
Mouse   306 M--LVRGHAYAVTGLEDVYYRDKLETLIRIQNPWGRVEWNGAWSDKATEWEEVSPDVRVQLL-HK 367

  Fly  1296 ASEGVFWISFEDVLNYFDCIDICKV----------RSGWNEVRLQGTLQ---------------- 1334
            ..:|.||:|:||.::.|..::||.:          :|.|:....:|:.:
Mouse   368 KDDGDFWMSYEDFMSNFTLLEICNLTPDALNTWDYKSRWHSTFYEGSWRRGSTAGGCRNHPETFW 432

  Fly  1335 --PLCSISCVLLTVLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRS-------PAAPEIG 1390
              |...||  |..|.:|.:           :|||::  .:..|:|....::       |....||
Mouse   433 SNPQFKIS--LPEVDDPED-----------DSEKNE--MVCTCLVALMQKNWRHAREGPQLLTIG 482

  Fly  1391 RLV------------EHSKRQV------RGF---------VGCHKMLERDIYLLVCLAFNHWHTG 1428
            .::            .|.|:..      .||         |..|..|....|:::...:
Mouse   483 FVIFSVPKEFQNLRDIHLKKDFFLKYRDHGFSEIFINSREVNSHLRLPPGEYVIIPSTY------ 541

  Fly  1429 IEDPHQYPQCILAIHSSKR---LLVEQISPSPHLLADAII-------SLTLTKGQRHEGRE---- 1479
              :||:....:|.:.:.|.   .|::..:...||..:.:.       ||.|.|...:|..|
Mouse   542 --EPHKDADFLLRVFTEKHSETWLLDDANRFEHLQEETVTDKDLDKDSLQLFKIMANEDGEVDMY 604

  Fly  1480 -------GMTA---YYLTKGWA-----GLVVMVE-------NRHE--------NKWIHV--KCDC 1512
                   .|||   .:.|||::     .::.:::       ..||        .||..:  :||.
Mouse   605 ALHKLLNRMTAKLRNFKTKGFSLEVCRRMINLLDKDGSGKLELHEFQVLWKKIKKWTEIFKECDE 669

  Fly  1513 QESYNVVS 1520
            ..|.|:.|
Mouse   670 DRSGNLNS 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035	7/34 (21%)
		RanBP2-type Zn finger	931..950	CDD:275376	6/30 (20%)
		CysPc	1001..1328	CDD:128526	107/349 (31%)
Capn11	XP_011244781.1	Peptidase_C2	95..391	CDD:366222	102/316 (32%)
		Calpain_III	413..559	CDD:366446	27/168 (16%)
		EFh_PEF_CAPN11	586..753	CDD:320068	21/92 (23%)
		EF-hand motif	586..614	CDD:320068	6/27 (22%)
		EF-hand motif	629..658	CDD:320068	2/28 (7%)
		EF-hand motif	659..688	CDD:320068	7/19 (37%)
		EF-hand motif	695..722	CDD:320068
		EF-hand motif	724..752	CDD:320068
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820