DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sol and clp-9

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	NP_001256150.1	Gene:	clp-9 / 266916	WormBaseID:	WBGene00011705	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	715	Identity:	224/715 - (31%)
Similarity:	345/715 - (48%)	Gaps:	85/715 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   931 WQCPACTYDNCAASVVCDICSSPRGL---------------------ASAVLGEALGRKS----- 969
            |.|..||..|..|..:|..|.|.:.|                     .|..:.:.:..:.
Worm     6 WNCLYCTLINDPAIFICQGCGSQKPLTKKPAKLTGSFPKIITDTVRDVSNAISDLVNNRDRSPAH 70

  Fly   970 --VRV----------------ALTPADIRQE---SKLMENLRQLEETEALTKWQNIIQYCRDNSE 1013
              ||.                :..|.|..|.   ||:...|:|..|.::...:.|||.||:.::.
Worm    71 NFVRATHFRTPLPNGPFVDGQSNDPRDTHQLSMCSKITTTLKQEAEKKSDVIYSNIISYCKSSNS 135

  Fly  1014 LFVDDSFPPAPKSL----YYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQG 1074
            .|:||||....||:    :........|....:.|.||.::....|...||:|...|.||||.||
Worm   136 PFIDDSFLHNKKSIGSLQFTKNGVKRHEEPDFLNWLRPSQMFTKDGRSSPWSVLNNPRPSDIEQG 200

  Fly  1075 VL-GNCWLLSALAVLAEREDLVKEVLVTKEICGQGAYQVRLCKDGKWTTVLVDDLLPC-DKRGHL 1137
            .| |:|||:||:|::|||.|::.:::..|:....|.||::||.:|||..::|||..|| .|...:
Worm   201 TLVGDCWLMSAMALIAERPDVLDDIIPKKQYSHYGVYQIKLCVEGKWEVIIVDDFFPCYSKTNSI 265

  Fly  1138 VYSQAKRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELD 1202
            ..:..:|.||||||||||:||:.|.|..|......:||:.||||.|    :..:..|:||..: |
Worm   266 AMAVGRRNQLWVPLIEKAMAKVLGSYSKLHGASLAQGLSMLTGASC----VNYNCPPIPSSVD-D 325

  Fly  1203 KDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQGHRLLKLRNPW 1267
            .|..||||:||:...|||...||.....|.|.|::..||...||||:|||...||:|||::||||
Worm   326 VDTFWAQLVSSKESGFLMCCHCGAFENVVAEAEFKAMGLLTNHAYSILDVIYEQGYRLLRIRNPW 390

  Fly  1268 GHYSWRGDWSDDSSLWTDDLRDALMPHGASE-GVFWISFEDVLNYFDCIDICKVRSGWNEVRLQG 1331
            |.:.|.|.|||....|...::...:.....| |.||:..||.:..|..:.:||:|..|:|:|:..
Worm   391 GQFVWNGKWSDGWPGWPIGMKQKFLNQRKDETGAFWMDLEDFVARFASVTVCKLRMDWSELRVTH 455

  Fly  1332 TLQPLCSISCVLLTVLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHS 1396
            .:.. .|.:.:.:.:.:..|...|.||:|..| :|...:.|.:||    .|......||.|:|.|
Worm   456 KVGG-HSDTALQIVITDTCEVSVTAFQKGAFN-KKDNLNDLMVCV----HRISGDRRIGELIEMS 514

  Fly  1397 KR-QVRGFVGCHKMLERDIYLLVCLAFNHWHT---GIEDPHQYPQCILAIHSSKRLLVEQISPSP 1457
            .| ....|......|....|.:||.:.:...|   |:.:        :.:|:...:..|.|..||
Worm   515 SRISDNHFTIDEFFLAPGEYQIVCHSQSSLLTNKKGVVN--------MVVHTRYPIFGEYIPMSP 571

  Fly  1458 HLLADAIISLTLTKGQRHEG-REGMTAYYLTKGWAGLVVMVENRHENKWIHVKCDCQESYNVVST 1521
            ....:::..:.:.:|...:. .:|:....||:.:.|:::|.:|..|.|::||..||.:|.|:.|:
Worm   572 RTRMESLHHVIIKEGDIVKNTNDGVVIRTLTRKFRGMIIMADNCLEKKYLHVGVDCSQSMNIQSS 636

  Fly  1522 RGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRGL--HDW-----GPPGATHCP 1579
            ||.|:.||.||||.|||::||:.::.|..:.:::.|...:..|:.|  ..|     ..|.|.|.|
Worm   637 RGFLQVVDVVPPLCRQVLLVLSTIDDSAQYRVSNSLKTLVHRSKCLLPEMWYEAAISAPNAQHYP 701

Fly 1580 1579
Worm 702 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035	9/22 (41%)
		RanBP2-type Zn finger	931..950	CDD:275376	7/18 (39%)
		CysPc	1001..1328	CDD:128526	133/333 (40%)
clp-9	NP_001256150.1	CysPc	123..453	CDD:128526	133/334 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158384
Domainoid	1	1.000	234	1.000	Domainoid score	I1341
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111762at33208
OrthoFinder	1	1.000	-	-		FOG0005761
OrthoInspector	1	1.000	-	-		otm14405
orthoMCL	1	0.900	-	-		OOG6_104309
Panther	1	1.100	-	-	LDO	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4152
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850