DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sol and Capn5

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	NP_604456.2	Gene:	Capn5 / 171495	RGDID:	620084	Length:	640	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	167/678 - (24%)
Similarity:	254/678 - (37%)	Gaps:	183/678 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1008 CRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPS-DI 1071
            |.....||.|..||....||||.     |...|.|:|:||.:| ||..     .:|...:.| |:
  Rat    20 CLRRKVLFEDPHFPATDDSLYYK-----GTPGPTVRWKRPKDI-CDDP-----RLFVDGISSHDL 73

  Fly  1072 CQGVLGNCWLLSALAVLAEREDLVKEVL---------VTKEICGQGAYQVRLCKDGKWTTVLVDD 1127
            .||.:||||.::|.:.||.||.|.::|:         ..|.....|.:.....:.|:|..|:|||
  Rat    74 HQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVVVDD 138

  Fly  1128 LLPCDKRGHLVYSQAKRK-QLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQAS 1191
            .|| .....|:|..:..| :.|..|:|||.||:.|||:||..|...:.|...||...|.|.|...
  Rat   139 RLP-TVNNQLIYCHSNSKNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEG 202

  Fly  1192 SLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQ 1256
            .|   :.||..:..::.::|.......|:.||. ......|.|.....||...|||:|.||:.::
  Rat   203 DL---ATDEAKRSQLFERVLKVHSRGGLISASI-KAMTAADMETRLACGLVKGHAYAVTDVRKVR 263

  Fly  1257 -GHRLL-----------KLRNPWGHYSWRGDWSDDSSLW---TDDLRDALMPHGASEGVFWISFE 1306
             ||.||           :||||||...|.|.|||.|..|   :...|:.:......:|.||::||
  Rat   264 LGHGLLAFFKSEKLDMIRLRNPWGEREWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFE 328

  Fly  1307 DVLNYFDCIDICK--------VRSGWNEVRLQGTL------QPLCSISCV------------LLT 1345
            |:..||..|..|:        :...|.|.||:|..      |...|..|:            :..
  Rat   329 DMCRYFTDIIKCRLINTSYLSIHKTWEEARLRGAWTRHEDPQQNRSGGCINHKDTFFQNPQYIFE 393

  Fly  1346 VLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHSKRQVRGFVGCHKM- 1409
            |.:|.:......|:..:.|.:.:....:|.:..         :|.::.|:  ||.|.....||.
  Rat   394 VKKPEDEVLICIQQRPKRSTRREGKGENLAIGF---------DIYKVEEN--RQYRMHSLQHKAA 447

  Fly  1410 ---------------LERDIYLLVCLAFNHWHTG------------------IEDPHQ------- 1434
                           |....|:::...|...|||                  :::|.:
  Rat   448 SSIYINSRSVFLRTELPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLC 512

  Fly  1435 -YPQCILAIHSSKRLLVEQISPSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVE 1498
             |||.:..:|                                           ..|.|||  ...
  Rat   513 GYPQQVTQVH-------------------------------------------VLGAAGL--KDS 532

  Fly  1499 NRHENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLAN 1563
            :...|.::.:||:.::..:.|. ||     .|.|....:.|....:|        :..:|.::.|
  Rat   533 STGANSYVIIKCEGEKVRSAVQ-RG-----TSTPEYNVKGIFYRKKL--------SQPITVQVWN 583

  Fly  1564 SRGLHD--WGPPGATHCP-PIENVHGLH 1588
            .|.|.|  .|.......| .::::|.||
  Rat   584 HRVLKDEFLGQVHLKTAPDDLQDLHSLH 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035
		RanBP2-type Zn finger	931..950	CDD:275376
		CysPc	1001..1328	CDD:128526	114/353 (32%)
Capn5	NP_604456.2	Peptidase_C2	27..341	CDD:279042	109/329 (33%)
		Domain III	344..496		26/162 (16%)
		Calpain_III	354..493	CDD:279416	26/149 (17%)
		C2_Calpain	515..638	CDD:176011	27/156 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920