DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sol and Capn5

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	XP_006507338.1	Gene:	Capn5 / 12337	MGIID:	1100859	Length:	653	Species:	Mus musculus

Alignment Length:	673	Identity:	175/673 - (26%)
Similarity:	249/673 - (36%)	Gaps:	173/673 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1008 CRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPS-DI 1071
            |.....||.|..||....||||.     |...|.|:|:||.:| ||..     .:|...:.| |:
Mouse    33 CLRKKVLFEDPLFPATDDSLYYK-----GTPGPTVRWKRPKDI-CDDP-----RLFVDGISSHDL 86

  Fly  1072 CQGVLGNCWLLSALAVLAEREDLVKEVL---------VTKEICGQGAYQVRLCKDGKWTTVLVDD 1127
            .||.:||||.::|.:.||.||.|.::|:         ..|.....|.:.....:.|:|..|:|||
Mouse    87 HQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVIVDD 151

  Fly  1128 LLPCDKRGHLVYSQAKRK-QLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQAS 1191
            .|| .....|:|..:..| :.|..|:|||.||:.|||:||..|...:.|...||...|.|.|...
Mouse   152 RLP-TVNNQLIYCHSNSKNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEG 215

  Fly  1192 SLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQ 1256
            .|   :.||..::.::.::|.......|:.||..... ..|.|.....||...|||:|.||:.::
Mouse   216 DL---ATDEAKRNQLFERVLKVHSRGGLISASIKAVT-AADMEARLACGLVKGHAYAVTDVRKVR 276

  Fly  1257 -GHRLL-----------KLRNPWGHYSWRGDWSDDSSLW---TDDLRDALMPHGASEGVFWISFE 1306
             ||.||           :||||||...|.|.|||.|..|   :...|:.:......:|.||::||
Mouse   277 LGHGLLAFFKSEKLDMIRLRNPWGEREWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFE 341

  Fly  1307 DVLNYFDCIDICK--------VRSGWNEVRLQGTL------QPLCSISCVLLTVLEPTEAEFTLF 1357
            |:..||..|..|:        :...|.|.||.|..      |...|..|:        ..:.|.|
Mouse   342 DMCRYFTDIIKCRLINTSYLSIHKTWEEARLHGAWTRHEDPQQNRSGGCI--------NHKDTFF 398

  Fly  1358 QEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHSKRQVR----------GFVGCHKMLER 1412
            |..|               .:|..:.|....:..:.:..||..|          ||
Mouse   399 QNPQ---------------YVFEVKKPEDEVLISIQQRPKRSTRREGKGENLAIGF--------- 439

  Fly  1413 DIYLLVCLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQI---SPSPHLLAD------AIISLT 1468
            |||            .:|:..||     .:||.:......|   |.|..|..:      .||..|
Mouse   440 DIY------------KVEENRQY-----RMHSLQHKAASSIYINSRSVFLRTELPEGRYVIIPTT 487

  Fly  1469 LTKGQRHE------------------------------GREGMTAYYLTKGWAGLVVMVENRHEN 1503
            ...|...|                              |.....|.....|.|||  .......|
Mouse   488 FEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVAQVHVLGAAGL--KDSPTGAN 550

  Fly  1504 KWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRGLH 1568
            .::.:||:.::..:.|. ||     .|.|....:.|....:|        |..:|.::.|.|.|.
Mouse   551 SYVIIKCEGEKVRSAVQ-RG-----TSTPEYNVKGIFYRKKL--------AQPITVQVWNHRVLK 601

  Fly  1569 D--WGPPGATHCP-PIENVHGLH 1588
            |  .|.......| .::::|.||
Mouse   602 DEFLGQVHLKTAPDDLQDLHTLH 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035
		RanBP2-type Zn finger	931..950	CDD:275376
		CysPc	1001..1328	CDD:128526	114/353 (32%)
Capn5	XP_006507338.1	Peptidase_C2	40..354	CDD:366222	109/329 (33%)
		Calpain_III	365..511	CDD:238132	36/194 (19%)
		C2_Calpain	528..651	CDD:176011	26/113 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820