DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sol and capn14

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	XP_031758480.1	Gene:	capn14 / 101732339	XenbaseID:	XB-GENE-22068150	Length:	722	Species:	Xenopus tropicalis

Alignment Length:	611	Identity:	159/611 - (26%)
Similarity:	251/611 - (41%)	Gaps:	150/611 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   950 CSSPRGLASAVLGEALGRKSVRVALTPADIRQESKLMENLRQLEETEALTKWQNIIQYCRDNSEL 1014
            |..||      |....|.|..:..|....:|:..:|...           .:|.:::......:|
Frog     5 CIMPR------LSFIKGGKKTKPLLRTGTLRKPRRLQSQ-----------DYQALLEKSLGGKQL 52

  Fly  1015 FVDDSFPPAPKSLYYNPASGAG---EGNP-VVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGV 1075
            |||::||.:..|:      |:|   :..| .|:|:||||:     ...|...........:.||:
Frog    53 FVDETFPASLASI------GSGCLLDKLPDCVEWKRPHEL-----VQNPQFCTENASEFGLHQGL 106

  Fly  1076 LGNCWLLSALAVLAEREDLVKEVLVTKEICGQ---GAYQVRLCKDGKWTTVLVDDLLPCDKRGHL 1137
            ..|||.|:||:.|....|::..|:...:...:   |.:..|..:.|:|..|:|||.||.:..|.|
Frog   107 TENCWFLAALSSLTFHPDILTNVVPQNQSFNKSYGGIFHFRFWRFGEWVDVVVDDRLPVNGEGKL 171

  Fly  1138 VYSQAKRKQL-WVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDEL 1201
            ::..:.||.| |.||:|||.||:.|.||.:..|:..|.|...||....||.: |.:.|     :|
Frog   172 LFVSSVRKNLFWGPLLEKAYAKLCGSYEDMQIGQVSEALVDFTGGVNMSIKM-AQAPP-----DL 230

  Fly  1202 DKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQ----GHRLLK 1262
            .:.::.||...|     |||.....|     .|.....||...|||:|:||:.:.    ...|:|
Frog   231 FQIMMRAQNSGS-----LMGCQTQTG-----PERVLDNGLVTGHAYTVMDVRQVTVKSVTENLVK 285

  Fly  1263 LRNPWGHYSWRGDWSDDSSLWTD-DLRDAL-MPHGASEGVFWISFEDVLNYFDCIDICKVRSGW- 1324
            ||||||...|.|.|||....|.. ..::.| :.....:|.||:|.||...:|..:.|||:....
Frog   286 LRNPWGKIEWTGKWSDRCPKWEQLSYKERLFLRKRREDGEFWMSIEDFEAHFVELVICKLTPDLM 350

  Fly  1325 -NEVRLQGTLQPLCSISC------------------------VLLTVLEPTEAE-FT-------- 1355
             :|:..:.||    |:.|                        ..|.:|:..:.| ||
Frog   351 SHEIGKEWTL----SMQCGRWSAGSTAGGRMTYTESYWLNPQYRLKILKGDDMEKFTNSCNVLVS 411

  Fly  1356 LFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLV----EHSKRQVRGFVGCHKML------ 1410
            |.|: |.:..::|...|.:.:.:|            ||    :..||..:.|...|:.:
Frog   412 LMQK-QSHKHRNQSPPLYIGMSVF------------LVPFEYQGVKRLPQKFFLTHRPINNKCVF 463

  Fly  1411 --ERDI----------YLLVCLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQISPSPHLLADA 1463
              ||::          |:::        ....:|:|..:.||.:.|.|.||.|| :.||:::
Frog   464 INEREVTQDYHLMPGSYVII--------PSTAEPNQECEFILRVFSRKHLLQEQ-TESPNIV--- 516

  Fly  1464 IISLTLTK-GQRHEGREGMTAYYLTK 1488
               |...| .:||  |.|:...:..|
Frog   517 ---LCCKKIAERH--RNGIWETFFNK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035	1/3 (33%)
		RanBP2-type Zn finger	931..950	CDD:275376	159/611 (26%)
		CysPc	1001..1328	CDD:128526	107/342 (31%)
capn14	XP_031758480.1	Peptidase_C2	53..344	CDD:395523	102/317 (32%)
		Calpain_III	365..500	CDD:395848	24/155 (15%)
		EFh_PEF	532..668	CDD:355382	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010