DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sol and capn10

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	XP_002935183.3	Gene:	capn10 / 100379827	XenbaseID:	XB-GENE-5770563	Length:	640	Species:	Xenopus tropicalis

Alignment Length:	678	Identity:	160/678 - (23%)
Similarity:	244/678 - (35%)	Gaps:	210/678 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1012 SELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDIC---- 1072
            |.||||..||....||.:...:.....:..:.|:|                     |.|||
Frog     6 SGLFVDSDFPAHVSSLVHGGDTQLSLHSDNISWQR---------------------PLDICASPS 49

  Fly  1073 ------------QGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQ---------GAYQVRLCK 1116
                        ||:||:||.:.|...|.:.:.|:.:|..    .||         |.:..|..:
Frog    50 LFSEKNRLNLGKQGILGDCWFICACTALQKYDRLLGQVFP----AGQCTWTNSNYLGQFTCRFWR 110

  Fly  1117 DGKWTTVLVDDLLPCDKRGHLVYSQAK-RKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTG 1180
            .|.|..|.:||.||| ....|.:|..: :...|:||:|||.||:|||||||.:|:..:.|..|||
Frog   111 FGCWVEVTIDDNLPC-LGNKLCFSHCQDQGAFWLPLLEKAYAKLHGCYEALWAGQVADALVDLTG 174

  Fly  1181 APCESIPLQASSLPMPSEDELDKDLIWAQLLS--SRCVRFLMGASCGGGNMKVDEEEYQQKGLRP 1243
            ...|...|:       |||:..::.::::|:|  .||      |.|    ..|.....:...|..
Frog   175 GLVERWSLE-------SEDDRGREKLFSKLVSLKDRC------AMC----CSVLHNRDRVMELGE 222

  Fly  1244 RHAYSVLDV-----KDIQGHRLLKLRNPWGHYSWRGDWSDDSSLWTD-DLRD-ALMPHGASEGVF 1301
            .|||::.|:     |..:...||:|.||||..||.|.|......|.| :|:| |.:.....||.|
Frog   223 LHAYTITDIQHVVTKSCKDLLLLRLHNPWGRSSWAGSWRKGGDGWNDLNLKDSARLLSEVQEGEF 287

  Fly  1302 WISFEDVLNYFDCIDIC-------KVRSGWNEVRLQGTLQPLCS-------------ISC----- 1341
            |:..::.|..||.|.|.       .::|.|.::.|....|...|             :|.
Frog   288 WVEKQEFLQEFDEITIAFPYSHEGHLQSIWTDLPLLHKQQFYGSWVKGYSAGGSRNNVSFPENPK 352

  Fly  1342 VLLTVLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHSKRQVRGFVGC 1406
            ..|.|.||:|...:|.|..|..               .:...|......|.:.|:|..:.. ||.
Frog   353 FWLRVKEPSEVFLSLMQIPQGG---------------VKIPEPVHGVYRRNLRHNKTAINA-VGI 401

  Fly  1407 H------------KML-------------ERDI----------YLLVCLAFNHWHTGIEDPHQYP 1436
            |            |.|             :|.:          |||:...|.....|
Frog   402 HVWKVEKRRFKLQKTLSSLPLAGTSSHCYDRQLHLCCNLSPGYYLLIPSIFLREAEG-------- 458

  Fly  1437 QCILAIHSSKRLLVEQISPS---PHLLADAIISLTLTKGQRHEGREGMTA--------------- 1483
            ..:|.|.|:....:.:.:||   |...||....:..|:....:.::|..|
Frog   459 NFLLRILSTGNFTLSECAPSWNIPSANADLTCGMWETQELSGQWKKGSNAGGSRNFASHIINPCF 523

  Fly  1484 -YYLTKGWAGLVVMVENRHENKWIH---------------------VKC----DCQE-SYNVVST 1521
             :.:..|...:.:|:..:|:.:..|                     |||    .||| |...|..
Frog   524 PFSVPDGTPMIKLMLRQQHDGEKCHAIGFHVYPVTSNQSVFSLEPCVKCIPHSHCQEVSKLCVLL 588

  Fly  1522 RGELKTVDS--VPPLQRQ-VIIVLTQLE 1546
            .|:...|.|  :|..:.. .:.:.|::|
Frog   589 PGQYTLVPSTYLPDQESDFTVTIATKME 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035
		RanBP2-type Zn finger	931..950	CDD:275376
		CysPc	1001..1328	CDD:128526	104/357 (29%)
capn10	XP_002935183.3	Peptidase_C2	9..303	CDD:395523	99/336 (29%)
		calpain_III	324..473	CDD:214786	29/172 (17%)
		Calpain_III	493..624	CDD:412194	21/124 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010