DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sol and capn9

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	NP_001121483.1	Gene:	capn9 / 100158582	XenbaseID:	XB-GENE-948345	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	640	Identity:	157/640 - (24%)
Similarity:	252/640 - (39%)	Gaps:	137/640 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   975 TPADIRQESKLMENLRQLEETEALTKWQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGN 1039
            ||..|....|..|.|:               ..|.....||.|..||....||:|:.....
Frog    18 TPRSIHSSGKTYEQLK---------------NDCLRKGVLFEDVDFPANDSSLFYSEKPSV---- 63

  Fly  1040 PVVQWRRPHEINCD-----GGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVL 1099
            |.| |:||.|:..|     |||      .||    |:|||.||:||||:|:|.|...:.::..|:
Frog    64 PFV-WKRPKEMVADPEFILGGA------SRT----DVCQGDLGDCWLLAAIASLTLNDKILYRVV 117

  Fly  1100 VTKEICG---QGAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVYSQAKRKQLWVPLIEKAVAKIHG 1161
            ...:...   .|.:..:..:..:|..|::||.||..:...:....|...:.|..|:|||.||::|
Frog   118 PPDQSFSTGYAGIFHFQFWQHNEWLDVVIDDRLPTFRNRLVFVHSADLNEFWSALLEKAYAKLNG 182

  Fly  1162 CYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGG 1226
            .||||..|..:|.:...||...|:..::  |.|....|.|||.:....:|.  |...:..::
Frog   183 SYEALKGGSTLEAMEDFTGGVTETYEIR--SAPANLFDILDKAIKKGSMLG--CSIDITSSA--- 240

  Fly  1227 GNMKVDEEEYQQKGLRPRHAYSV--LDVKDIQGH--RLLKLRNPWGHYSWRGDWSDDSSLWT--- 1284
                 :.|....:||...||||:  .||.:.:|.  :|:::|||||...|.|.|||:||.|.
Frog   241 -----ETEAKTPQGLVKGHAYSITGADVVNFKGQKVKLIRIRNPWGQVEWNGAWSDNSSEWNIIG 300

  Fly  1285 DDLRDALMPHGASEGVFWISFEDVLNYFDCIDICKV---------RSGWNEVRLQGT-------- 1332
            ...::.|......:|.||:.|||...:||.::||.:         :..|.....:|:
Frog   301 AAEKNRLSQASLDDGEFWMDFEDFKRHFDKLEICNLTPDSLDDDAKHKWEVTVHEGSWIRGSTAG 365

  Fly  1333 -----LQPLCSISCVLLTVLEPTEAE------FTLFQEGQRNSEKSQRSQLDLCVVIFR---TRS 1383
                 |:...|...:.|::.|..:.:      ..|.|:.:|...|:....|.:...|::   :.|
Frog   366 GCRNFLETFWSNPQIKLSLTEQDDGQKECTFIAALMQKNRRKLRKTGADLLTIGYTIYQCPGSES 430

  Fly  1384 PAAPEIGRLVEHSKRQVRGFVGCHKMLER-----DIYLLVCLAFNHWHTGIEDPHQYPQCILAIH 1443
            ..:.:..:. ..||.:.:.:|...::.:|     ..|:.:...|        :|||.....|.|.
Frog   431 ILSKDFFKF-NPSKARSKTYVNLREISQRFKLPPGDYMFIPTTF--------EPHQEADFCLRIF 486

  Fly  1444 SSKRLLVEQIS----------PSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVE 1498
            |.|:..::::.          |:|          |....:..|.|:..|.:....| ..|.|..|
Frog   487 SEKKADIKEMDGEVNIDLPDPPAP----------TPPHKETEEERQFRTLFEQISG-QDLEVSAE 540

  Fly  1499 NRHENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSG--GF 1551
                        :.|...|.|..|.:......:..|....||.|....|:|  ||
Frog   541 ------------ELQYVLNAVLRRTKNIKFKEMSLLSCNNIISLMDASGNGKLGF 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035
		RanBP2-type Zn finger	931..950	CDD:275376
		CysPc	1001..1328	CDD:128526	104/350 (30%)
capn9	NP_001121483.1	Peptidase_C2	43..335	CDD:366222	100/318 (31%)
		Calpain_III	356..491	CDD:366446	25/143 (17%)
		EFh_PEF_CAPN9	522..691	CDD:320067	17/75 (23%)
		EF-hand motif	522..550	CDD:320067	7/40 (18%)
		EF-hand motif	565..594	CDD:320067	7/19 (37%)
		EF-hand motif	595..625	CDD:320067
		EF-hand motif	631..659	CDD:320067
		EF-hand motif	661..691	CDD:320067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010