DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sls and Hmcn2

DIOPT Version :9

Sequence 1:	NP_001261304.1	Gene:	sls / 44013	FlyBaseID:	FBgn0086906	Length:	18468	Species:	Drosophila melanogaster
Sequence 2:	XP_006498564.1	Gene:	Hmcn2 / 665700	MGIID:	2677838	Length:	5092	Species:	Mus musculus

Alignment Length:	5145	Identity:	1081/5145 - (21%)
Similarity:	1641/5145 - (31%)	Gaps:	1740/5145 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 KNARFAQGGNALFEGRLRGNPKPFVTWTRKGAPLLESQKFRMSYNEATGDVSLLINQIGPGDEGE 158
            ::.||:||..........|.|.|.::|:|:|..|.|..:..:   :|.|  :|:|..:.|.|.|.
Mouse   616 RSQRFSQGVEVRVSCSASGYPTPHISWSREGLALPEDSRIHV---DAQG--TLIIQGLAPEDAGN 675

  Fly   159 YTCTARNQYG---EAICSVYIQPEGAPMPALQPIQNLEKNIYSNGYSYTSIEEEF---------- 210
            |:|.|.|:.|   |.:...|..|     |::..:         |....|::.||.
Mouse   676 YSCQATNEVGTDEETVTLYYTDP-----PSVSAV---------NAVVLTAVGEEAVLLCAASGVP 726

  Fly   211 --RVDTFEYRLLREVSFREAITRRSG-------YEQDSQL------------SQELDRNQGPAQA 254
              ||  ..||...||..... ..|||       .|:|:.|            |.|:....|  .|
Mouse   727 PPRV--IWYRGGLEVILAPG-DSRSGTLRIPEAQERDAGLYTCKAVNELGDASAEIQLVVG--NA 786

  Fly   255 PQISQKPRSSKLIEGSDAVFTARVGSNPKPRLTWFH-NGQRLVASQKYEISY-SSGVATLRVKNA 317
            |:::..|:...:..|.....|.|....|.|.:||.. :||.|...:...... .|||  |..:..
Mouse   787 PRLTDPPQDVTVELGKSVFLTCRATGRPPPIVTWRRGDGQALEPGRGSRTGQRDSGV--LVFERV 849

  Fly   318 TARDGGHYTLLAENLQGCVVSSAVLAV----------EPAAETAYEPKPVDV---------MAEQ 363
            :..|...|...|.|:.|...:.|.|.|          ..:.....|.:||.:         :.|:
Mouse   850 SLEDQAPYVCEARNVFGKAQAEARLVVTGHAPPQIANSASVVRVLEGQPVSLTCVILAGRPLPER 914

  Fly   364 --LEAGKALPPA---FVKAFG----DREI------------------------------------ 383
              |:||..|||.   .|:|.|    ||.:
Mouse   915 RWLKAGSPLPPGNRHAVRADGSLHLDRALQEDAGRYSCVATNVAGSQHRDVELVVQVPPRIHPTS 979

  Fly   384 -----TEGRMTRFDCRVTGNPYPEVFWLINGRQVRDDASHKILVNESGSHSLMITNVTRLDAGAV 443
                 .||......|..:|.|.|::.|......:.....:.:    |.:.:|:|...:..||||.
Mouse   980 THHVTNEGVPASLPCIASGVPTPKITWTKETNALTTSGHYSV----SRNGTLVIVQPSPQDAGAY 1040

  Fly   444 QCLARNKAGEVAIEAQLNVLEKEQVV--APQFVQRFSTMTVREGEPITMSANAIGTPQPRITWQK 506
            .|.|.|..|..:.|..|:|..|..:.  ..|.|.....:||:.||.:|:...|.|:|.|.:||.|
Mouse  1041 VCTATNSVGFSSQEMWLSVNTKPMIKMNGSQAVDVPLRVTVKAGEEVTLDCEAQGSPTPLLTWTK 1105

  Fly   507 DGVQISSTAERFVGIDGGATCLEIPRVTANDAGWYQCTAQNIAGSTANRARLYVEVPRE-QPNYE 570
            |...:.....|:..:..|:  |.:.:....|.|.|.|||.|.||:|:.|..|.|:||.: ||.
Mouse  1106 DANPLLPVTNRYELLPSGS--LRLAQAQVGDNGLYGCTASNPAGATSRRYVLRVQVPPQVQPG-- 1166

  Fly   571 QRRLNLPRPTKVIEPEPI---------PGPEI-----------------IYLRHVERAKPHLRPG 609
                  ||..||:..|.:         |.|::                 ::...|:.:...|...
Mouse  1167 ------PRVLKVLAGEALDLNCVAEGNPQPQLNWFKDGMALMGEGAQGSVHFAAVKTSDAGLYRC 1225

  Fly   610 EEDRVYPPPQFIIPLQNVQQTEGGRVHMEARIEPV------------GDPTMVVEWY-------L 655
            |.........:.:.|..::....|....::.:|.|            |.|...:.|.       |
Mouse  1226 EASNSAGTDTWKLELLVLEPPHWGTDETKSLLERVAGENASLPCPAQGTPKPRITWRRGPSSEPL 1290

  Fly   656 NGRPLAASARATSVFKFGFIALDLLSIMGHDSGEYMCRVTNASGVAESRAILSVVQRPSIEQSSQ 720
            ||||..|.....|:|        |.|:...|||||.|:.||..|.|..||.|.|...|||.:...
Mouse  1291 NGRPDVAVLDEGSLF--------LSSVSLADSGEYECQATNEVGSASRRAKLVVYVPPSIREEGH 1347

  Fly   721 NPNSLQYINQLEDYSRYQRTESIDEQLNQAPQFIRPLR---DLGEFEEGKNVHFEAQVTPVNDPS 782
            ..|......|                         ||.   |:..|                 |:
Mouse  1348 ITNVSGLAGQ-------------------------PLTLECDINGF-----------------PA 1370

  Fly   783 MRVEWYKDG--LPITASSRITAIFNFGYVSLNILHLRAEDAGTYTVRAVNRIGEAISQSSIRVHS 845
            ..|.|.|||  :|..:..|:..    |..||:...::...:|.|:.:|.|:.|.|....::.|
Mouse  1371 PEVAWLKDGQLIPEASGHRLLD----GSRSLHFPRIQESHSGLYSCQAENQAGSAQRDFNLAV-- 1429

  Fly   846 RSQVTADLGIPEQQRYIEKVEELEDYRKSQQRRHVQEAAEAIAPPQF--KTPIQNQLDLREHAHA 908
                                                     ..||..  ....|..|.|   |.|
Mouse  1430 -----------------------------------------FIPPSLLGAGAAQEVLGL---AGA 1450

  Fly   909 HFEARLEPVGDSTMRVEWLKDGQPLEASSRITTYHNFGYVALTIKQLTIYDAGTYTCRAYNAMGQ 973
            ......:..|..|.:|||.|||||:............|.| |.|....:.|.|.|.|.|::..||
Mouse  1451 DVTLECQTSGVPTPQVEWTKDGQPILPGDPHILLQEDGQV-LRIISSHLGDEGQYQCVAFSPAGQ 1514

  Fly   974 DTTVAQLTVISKNEIVSESQHPGGLQKIQHLEDSSRYGRREEEETYITQAPRFLGPLK-GTTKIL 1037
            .....||::           |.|        :..::.|.|....:|  ..|...|..: |...:|
Mouse  1515 QAKDFQLSI-----------HYG--------DPEAQRGERTYPRSY--TPPTIWGSNETGEVTVL 1558

  Fly  1038 EGQRAHF--EARVEPQSDLGLVIEWYHNGRSITAANRIQTYYDFGYVALDISQVRAEDAGVYLVV 1100
            ||..|..  |||..|..    .|.||.:|..:..::.:  .|..|...|.:.:.:..|||:|...
Mouse  1559 EGHTAQLLCEARGMPSP----AITWYKDGTLLAPSSEV--VYSKGGRQLQLVKAQPSDAGLYTCQ 1617

  Fly  1101 ARNKLGEAQQQATMIVETRSSIDTSSMHRGLYEKTQNLENKPFVEPQYDIEEISKSKPVFVTPLS 1165
            |.|.                        .|:.:|:.:||  .:|.|..   |.:...|..|..::
Mouse  1618 ASNP------------------------AGITKKSTSLE--VYVPPTI---EGADGGPYLVQAVA 1653

  Fly  1166 DPKPIHDGKNIHLECRLEPMGDPTMRVEWFHNGRPVTVGSRFRTYYDFGFVALDIIKATAADSGE 1230
                   |:.:.|||  ...|.|...:.|.|.|.||...:  .|:.:.| .||.:.....|..|.
Mouse  1654 -------GRPVALEC--VARGHPPPTISWQHEGLPVVDSN--GTWLEAG-GALQLENPGEASGGL 1706

  Fly  1231 YTVRATNHLGTAHTSACVRVIDHTDVVTETQNEQSLEQIQLLEDSRRRHHQEEDITIMQAPQ--- 1292
            |:..|::..|.|       |:.:           |:|                    ||.|.
Mouse  1707 YSCVASSPAGEA-------VLQY-----------SVE--------------------MQVPPQLL 1733

  Fly  1293 FTRGLHNIETIEGTNVHLECRLQPVGDPSMRIEWFVNGKPVKTGHRFRPAYEFDYVAL----DLL 1353
            ...|:..:....|.::.|.|  |..|.|...|:|..||         |||.|...|.|    .:|
Mouse  1734 VAEGMGQVTATVGQSLDLPC--QASGSPVPTIQWLQNG---------RPAEELAGVQLASQGTIL 1787

  Fly  1354 GCYAID---SGVYTCQARNQLGEAVTSCSVRIIAKNDLILETQNESGLQKIQYLEDSTRHRRSEF 1415
            ....::   ||::.|||.|:.|.|                      |.:    :|.|.....|..
Mouse  1788 HISHVELNHSGLFACQATNEAGTA----------------------GAE----VEVSVHELPSVH 1826

  Fly  1416 VDEVVNIRPRFLTHPKSLTNTREGGHAHFECKIEPVTDPNLKVEWFKNGRPI-TVGHRFRPIHDF 1479
            :....|:...|| .|.:|           :|....|..|:|:  |:|:|..: |.|
Mouse  1827 IIGGENLTAPFL-QPVTL-----------QCVGIGVPTPSLR--WWKDGVAVATSG--------- 1868

  Fly  1480 GYVALDIVHLIAEDSGVYTCRAVNLIGSDETQVELQCRSGEQIVTVTQN-EAGLEQIHYLEDRSR 1543
            |.:.::...|  .|.|||||.|.||.|..:..|.|:       |.|..| |.|
Mouse  1869 GNLQIEKADL--RDEGVYTCSATNLAGESKKDVTLK-------VLVPPNIEPG------------ 1912

  Fly  1544 YTRREEIDESTKQAPVFTTSLKNVEIKENQRAHFECRLIPVSDPSMRVEWYHNNLPLKSGSRFTE 1608
                          ||      |..:.||.....||....|..|.  |.|:....|:.:..|...
Mouse  1913 --------------PV------NKVVLENASVTLECLASGVPPPD--VSWFKGRQPISTQRRVIV 1955

  Fly  1609 TNNFGFVALDIMSTLPEDAGTYTCRAYNAVGEAITSAVAVVHTKKSIYLESQHETALPRLQHLED 1673
            :.: |.| |.|......|||:|.|.|.|..|.|                            .|:.
Mouse  1956 SAD-GRV-LHIERVQLSDAGSYRCVATNVAGSA----------------------------GLKY 1990

  Fly  1674 GSKRQRISVQDEFVSQAPVFTMPVRDVRVAEN------QAVHFEARLIPVGDPKLTVEWLRNGQP 1732
            |.:          |:..|..|:|       .|      ....|.......|.|:.|:.||::|.|
Mouse  1991 GLR----------VNVPPRITLP-------PNLPGPVLLGTPFRLTCNATGTPRPTLIWLKDGNP 2038

  Fly  1733 IEASNRTTTMHDFGYVALNMKYVNPEDSGTYTCRAVNELGQAVTSASLIVQSKTSIQLETQHEAA 1797
            :............|...|.:......|||:|:|.||:.:|:......|.|....||.
Mouse  2039 VSPEGIPGLKVFPGGQVLTVASARASDSGSYSCVAVSAVGEDRRDVILQVHMPPSIL-------- 2095

  Fly  1798 MHKIHQLEDHSRYQRREEEEYTVTTAPVFVTKLIGPSNLVEGQSAHYECRIEPYPDPNLKVEWFH 1862
                             .||..:              ::|..:|...||:....|.|.|:  |..
Mouse  2096 -----------------GEELNM--------------SVVVNESVTLECQSHAVPPPVLR--WQK 2127

  Fly  1863 NGKPLSTGHRFRTTYDFGFAALDILTVYAEDSGEYTCRVTNNLGEAINSIVLNVTSRSSIIHETQ 1927
            :|:||......|.:.|.....:|...|:  |:|.|||...|..|.:.....|:|....:
Mouse  2128 DGRPLEPHPGIRLSADKALLEVDRAAVW--DAGHYTCEAINQAGRSEKHFNLHVWVPPA------ 2184

  Fly  1928 HEEALTKIQHLEDTSRFQRKTDEEQFHAERPQFGRPLRNAKVNEGAPVHLEATLIPVNDPTMKVE 1992
                                     |.::.|.      ...|.||....|......:  |..|:.
Mouse  2185 -------------------------FPSKEPY------TLTVTEGQTARLSCDCQGI--PFPKIS 2216

  Fly  1993 WYCNGRPIQ-TGHRFKTTYDFGFVALDILY---AHAEDTGTYMCKAKNAIG-------------- 2039
            |..:|:|:. .|...:.....|    .:||   |.:...|||.|:..||.|
Mouse  2217 WRKDGQPLPGEGDSLEQVLAVG----RLLYLGQAQSAQEGTYTCECSNAAGTSSQEQSLEVLVPP 2277

  Fly  2040 ------EAVTTCAVNVTANKTLDLDTLDAQRLEKIRQLETYAPPPKPVV--EEKGQKPIFLTPLS 2096
                  |.:||.:|....|.||..:.               ...|.|||  :..|| |:.:.|..
Mouse  2278 QVTGLWEPLTTVSVIQDGNTTLACNA---------------TGKPLPVVTWQRDGQ-PVSVEPGL 2326

  Fly  2097 NLE------HLKEGEHAH----------------------------------------------- 2108
            .|:      |::..:.:|
Mouse  2327 RLQNQNHSLHVERAQASHAGGYSCVAENTAGRAERRFALSVLAPPHLTGDSDSLTNVTATLHGSF 2391

  Fly  2109 -LECRVEPINDPNLKIEWFCNGKQLPTGHRYRTTHDFGYVALDILYVYGEDTGTYICKATNQLGE 2172
             |.|....:..|.  ::||..|:  |...|..|....|...|.:.....:|.|.|.|.|:|:.||
Mouse  2392 TLLCEAAGVPAPT--VQWFQEGQ--PISPREGTYLLAGGWMLKMTQAQEQDRGLYSCLASNEAGE 2452

  Fly  2173 AVNTCNVRVLNRRSMILDTQHPDALEKIQKLES--KVPNARTEVGDAPISPPHFTAELRGSTEIY 2235
            |          ||:..::...|.::|. :.||.  |||
Mouse  2453 A----------RRNFSVEVLVPPSIEN-EDLEEVIKVP--------------------------- 2479

  Fly  2236 EGQTAHFEAQVAPVHDPNLRIEFYHNGKPLPSASRFHITFDFGYVSLDITHAVAEDAGEYSVRAV 2300
            |||||..|.. |..|.|. ::.::.:|:.|.....:.::.|..:  |.|..|...:||.||..|.
Mouse  2480 EGQTAQLECN-ATGHPPP-KVTWFKDGQSLTVEDPYEMSPDGAF--LWIPQANLSNAGHYSCIAS 2540

  Fly  2301 NALGQAVSSTNLRVIPRGTIISDTQHPEGLEKIRKLESTAPHQRQEPETPGTRQRPVFTQPLQNI 2365
            ||:|:....|.|.|:...||:.                 .|.:....|...|...|:
Mouse  2541 NAVGEKTKHTQLSVLVVPTILG-----------------VPEKNANEEVTVTINNPI-------- 2580

  Fly  2366 DRINEHQTAHFEARLIPVGDPNLKVEWYRNEKIIEDSSRITKQHDFGFVSLDISHIRKEDEGVYM 2430
                   :...||...|  .||  :.|.::....|.|..|  |...|...|.|.:.:|||.|.|.
Mouse  2581 -------SLICEALAFP--SPN--ITWMKDGSPFEASKNI--QLLPGTHGLQILNAQKEDAGQYT 2632

  Fly  2431 CRAVNPLGEAVTTASMRVVSEASIQMDTQHPDSISRIHQLEKPLAPRPTEPERLFEKPIFTQL-- 2493
            |...|.||||.....:.|:.          |.|||:    :.||.       .:..|.:.|::
Mouse  2633 CVVTNELGEATKNYHVEVLI----------PPSISK----DDPLG-------EVSVKEVKTKVNS 2676

  Fly  2494 -LTGPSELWEGTHAHFEARVVPVGDPSLKFEWFINGVELQMGSRLRTTHDFGFVTLDITAVVPED 2557
             ||...|.|              ..|.....|:.:|..:....||....:...:.:..|.|  .|
Mouse  2677 SLTLECECW--------------ATPPPSISWYKDGRPVTPSHRLSVLGEGRLLQIQPTQV--SD 2725

  Fly  2558 AGVYMCRAYNAAGEAVSSTAMKVKTKSNIDGQPLIPESWEAIRLKEAAMNRVPEMFVDSTPQQAP 2622
            :|.|:|.|.|.|||......:.::..........:...:|.:..:|.|..||.|
Mouse  2726 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKMGDVDAGFEPLPHEEEAQGRVTE----------- 2779

  Fly  2623 VFTTHLQSYDKLHEGQHVLLEAQVEPRADPNLRIEWFK--------NGISLTTGSRIRSTFDFGL 2679
                    |.::.|.....|  ..:..|.|...:.|::        :|:|:..|.||
Mouse  2780 --------YREIVENNPAYL--YCDTNAIPPPELTWYREGQPLSAADGVSVLQGGRI-------- 2826

  Fly  2680 VTLSINGLRADDSAIYTCKATNQVGEAVSTSSLKIEDRHWLQAESLHPDSLPRIGELEAPKEGRP 2744
              |.:..::|:|:..|:|||.|:|||            .||..|.|          :..|    |
Mouse  2827 --LQLPLVQAEDAGRYSCKAANEVGE------------DWLHYELL----------VLTP----P 2863

  Fly  2745 EAPEPTYETPVFITHLNNIECKESDNVRFECNVEPA-RDPTMSIEWFYNGQPLQAAAKFKSIYDF 2808
            ..|..|.|.      :..:....|..|..||   || .:|..::.||.||.|:..:.:.: :.:.
Mouse  2864 VIPGDTQEL------VEEVTVNASSAVSLEC---PALGNPAPAVSWFQNGLPVSPSPRLQ-VLEE 2918

  Fly  2809 GYCALDLTNSYAENSGVYTCKATNSKGSATTSGTLKCTGGKTMFLDTQHPQGEAGLEAVQETEEE 2873
            |. .|.:..:...::..|.|.|.|..|||....|||
Mouse  2919 GQ-VLKVATAEVADAASYMCVAENQAGSAEKLFTLK----------------------------- 2953

  Fly  2874 LANRYTSKTTKPETQYPPPV--W-TKPLQAEFHLSEAQPIHLEANVEPKEDPNLFIEWYFNGKML 2935
                         .|.||.:  | |..|.|..:.|.:.|..:.|:      ||..:.||.:|:.|
Mouse  2954 -------------VQVPPQISDWTTSQLTATLNSSVSLPCEVYAH------PNPEVTWYKDGQPL 2999

  Fly  2936 NHGSRFKMTSEFGFVTMDMIEVYARDQGIYTCKAYNKAGEAFTSTTIFCSSKENIIESTQHPKGA 3000
            :.|....:..  |..|:.:......|.|.|.|:|.|.||.
Mouse  3000 SLGQEAFLLP--GTHTLRLARAQPADSGTYLCEALNAAGR------------------------- 3037

  Fly  3001 EGLEQIQDLEDSLRKDGSKPEQPDLGIPPRF------TTEFVNIADIGEGELAHFEANLIPVGDQ 3059
                            ..|..|.::.:||.|      ..|.:.:. .|:..:...|.:.:|
Mouse  3038 ----------------DQKMVQLNVLVPPSFKQAPGGPQEAIQVR-AGDKAILSCETDSLP---- 3081

  Fly  3060 SMVIEWFYNGKVLEASHRVRTIYAFGTVALEVLGTKIEDTGTYTCRATNKHG------------- 3111
            ...:.||.:.:.|....|::.:.  |...||:|.::..|.|.|:|:.:|..|
Mouse  3082 EPAVTWFKDQQPLALGQRIQGLQ--GGQTLEILDSQASDKGVYSCKVSNTAGEAIRTFVLAIQVP 3144

  Fly  3112 -----------------TAEISCNLECVDKP---------------------RGQKPRFTSHIQP 3138
                             |..::|::..:..|                     ||.:.:. ||:||
Mouse  3145 PTFEKPERETVNQVAGRTLVLACDVSGIPAPTVTWLKDRLPVESSVVHGVVSRGGRLQL-SHLQP 3208

  Fly  3139 LEGLKDGQSAHFEC----------------TLIPVNDPDLKVEWYHNGKLMRHSNRIKTVSDFGY 3187
                  .|:..:.|                .|:|....|..:...|| .|.:...|:...:: |.
Mouse  3209 ------AQAGTYTCVAENAQAEARKDFVVSVLVPPQIQDSGMAQEHN-VLEKQEIRLHCEAE-GQ 3265

  Fly  3188 VVLDISYLQD----------H------------------DSGEYVCRAWNKYGEDFTRTTLNCGG 3224
            ...||::|:|          |                  |||.|.|.|.|..|||....|:|.
Mouse  3266 PPPDITWLKDGGLLDQHVGPHLRFYLDGSTLVLKGLRTADSGAYTCVAHNPAGEDARLHTVNV-- 3328

  Fly  3225 RGGVFYDSLQPDSLQRIRELECPQGQQADTSAPLVAEPPKFITQIVDVTKLVEGQSAHFEARLTP 3289
                    |.|.:::          |||..:..||:...:.:|.:..    |:|
Mouse  3329 --------LVPPTIK----------QQAGDTGTLVSRTGELVTMVCP----VQG----------- 3360

  Fly  3290 ITDPDLVVEWYFNGKKLPHGHRFRTFHDFGIVILDILYCYEENSGVYEARARNKYGEDVTRASLK 3354
              .|.:.|.|..:|..||...| ...|..|.. |.|......:|||:                 .
Mouse  3361 --SPPIHVSWLKDGLPLPLSQR-TLLHSSGRT-LRISQVQLADSGVF-----------------T 3404

  Fly  3355 CASKSSLILDSQLPRGMEGGLEKIANLEYSMVRTREETTEETKGKAPVFTVPLENIENLREGENA 3419
            |.:.|        |.|       :|:..::::..           .|....|:|...|:...:.:
Mouse  3405 CVAAS--------PAG-------VADRNFTLLVL-----------VPPILEPVEFQNNVMAAQGS 3443

  Fly  3420 HF----EARITPADDPKLKVEWYWNGRPLKAGSRFRTFCDFGFVILEISP------VYPEDSGEY 3474
            ..    |||.:|..    .|.|..:|.||...|            ||..|      |...|:|.|
Mouse  3444 EVVLPCEARGSPLP----LVSWMKDGEPLLPQS------------LEQGPGLKLESVSVGDAGTY 3492

  Fly  3475 SCRAINEYGEAVTTATMKIQGKRSIIMESQLPKGMEGTIDRIAELEGLGSRSTEFVPDDDTGKPP 3539
            ||.|.:|.|||          :|...:....|..:|                       ::|:..
Mouse  3493 SCTAASEAGEA----------RRHFQLTVMDPPHIE-----------------------ESGETS 3524

  Fly  3540 EFITSPFDMVIGENALAHFECRLQPINDPSMRVDWFHNGKALWAGSRIKTINDF-GFVILEIAGC 3603
            |...:|.         ||.|...:....|...:.|..:|:||     .:|.||. ...:|.:...
Mouse  3525 ELSLTPG---------AHLELLCEARGIPPPNITWHKDGQAL-----RRTENDSQAGRVLRVRDV 3575

  Fly  3604 YQRDSGLYTCKATNKHGEATVSCKLQVKGRQGIVMEPQLPSNFRTGTESLQKLEETMHKREELVT 3668
            ...::|||||.|.:..||...|.:::|:....:|
Mouse  3576 QVDNAGLYTCLAESPAGEVEKSFRVRVQAPPNVV------------------------------- 3609

  Fly  3669 EDEQPNPPKFTEEIKDNLDVPEGGPIHFDCRVEPVGDPTMRIEWFYNGHVMATGSRVHQLNDFGF 3733
               .|..|:....:..       |.:..:|.||  .:|...|||...|.::...:..|......|
Mouse  3610 ---GPRGPRSVVGLAP-------GQLILECSVE--AEPAPEIEWHRGGVLLQADAHTHFPEQGRF 3662

  Fly  3734 IALDVDYIYARDSGEYTCRATNKWGTATTSAKVTCKGKHNIVYESQLPEGMTSEKLKELERGRIP 3798
            :.|..  :...|.|:|:|.|.|:.|:.:.:.:|                             .|.
Mouse  3663 LKLQA--LSTADGGDYSCTARNRAGSTSVAFRV-----------------------------EIH 3696

  Fly  3799 EAPKVVEEVFGPPKFTTQITSVTVDEAEAVRFECQVEPKTDPSLRVEWYRNGKPLPSGHRYRNIF 3863
            .||.:..   ||......:...|:       ..||....  |:..|.|.::|.||..|.......
Mouse  3697 TAPTIQS---GPNTVNVSVNRTTL-------LPCQTHGV--PTPLVSWRKDGIPLHPGSPRLEFL 3749

  Fly  3864 DMGFVSLDILYVYGEDSGEYVCRAINNYGEDR-------------------------TRATVSC- 3902
            ..|  ||.|..|..:|:|.|:|.|.|:.|.||                         :.|::.|
Mouse  3750 PEG--SLRIHPVLAQDAGHYLCLASNSAGSDRKGLDLRVFEPPAIAPGPSNLTLTAYSPASLPCE 3812

  Fly  3903 -----KKLPTILLQNQ-----VPRGMKR---SDAL----------TQMEATI--------KKYTS 3936
                 |.|.|.....|     :.:|..|   |:||          .|.|..:        ::|..
Mouse  3813 ARGSPKPLVTWWKDGQKLDLRLQQGAYRLLPSNALFLTAPSPQDSAQFECVVSNEVGESRRRYQV 3877

  Fly  3937 EVHLTEDDLFDPDRKQPPRFVTQIKEQLTLTEMAVTKFECQLAPVGDPNMKVEWFFNGKPLLHKN 4001
            .||:            ||. :...:...|:|.||.....|.  ..|.|...|.|...|..|..:.
Mouse  3878 TVHV------------PPT-IADDQTHFTVTRMAPVILTCH--STGSPTPAVSWSKAGTQLGARG 3927

  Fly  4002 RFQPIYDFGYVAMNFGWVYPEDSGEYVCRATNLYGKDETRAIIKVSGKPGIVYDSQLPAHMQSID 4066
            ....|...|  |:......|..:|.|.|.|.|..|......::.|...|.:   ..||:.:|.:
Mouse  3928 SGYRILPSG--ALEIERALPLHAGRYTCTARNSAGVARKHMVLTVQASPVV---KPLPSVVQVV- 3986

  Fly  4067 RIREMEASWQV-VPDEVDPDAKPRTKPVFVSKLEPQTVEEGDPARFCVRVTGHPRPRVMWLINGH 4130
                  ||.:| :|.|                                 .:|.|:|.|:|...|.
Mouse  3987 ------ASEEVLLPCE---------------------------------ASGIPQPMVIWQKEGL 4012

  Fly  4131 TVVHGSRYKLTNDGMFHLDVPKTRQYDTGKVEVIARNSVGESIATTELKVVARSDDYRNVLKNSP 4195
            ::..|:..::...|  .|.:......|.|....||:||||.::|.|.|.|
Mouse  4013 SIPEGAHMQVLPSG--QLRIMHASPEDAGNYFCIAQNSVGSAMAKTRLVV--------------- 4060

  Fly  4196 RPWYDYELAAYQKERQENELEKVFDERKQVLSEQSSHTLKGVEHLKP---KQYKPPTPDWQQNVK 4257
                              ::..|.:.....||     |::|...|.|   |....|...|:::..
Mouse  4061 ------------------QVPPVIENGLPDLS-----TIEGSHALLPCTAKGSPEPAITWEKDGH 4102

  Fly  4258 AKKSEDYYNKLQTLETEQLLKETNLRRDTHQYAIPGEKVVSSSQAKGMAQSYEENLQEKTSTTEV 4322
            .....:  .|.....:.:||.:.:..:|...|....|..|..::
Mouse  4103 LVSGAE--GKFTLQPSGELLVKNSEGQDAGTYICTAENAVGRAR--------------------- 4144

  Fly  4323 QAAPPKGIAQPSESSVHGREVHMNKQQQVQKEIQGDLEITRKITATETTEVEHKGTIQERVVQGP 4387
                              |.||:                                ||
Mouse  4145 ------------------RRVHL--------------------------------TI-------- 4151

  Fly  4388 VKPAKAPVFTKKIQPCRVFENEQAKFEVEFEGEPNPTVKWYRESFPIQNSPDLQIHTFSGKSILI 4452
               ...||.|.......:...::........|.|.|.:.|.....|:......|    .|.|.|.
Mouse  4152 ---LTLPVLTTLPGDRSLRLGDRLWLRCVARGSPTPRIGWTINDQPVTEGVSEQ----DGGSTLQ 4209

  Fly  4453 IRQVFVEDSAVFSCVAENRGGTAKCSANLVVEERRRAGKGGIQPPSFVTTIQSTTVATGQLARFD 4517
            ...|..|||..::|.||||.|..:..:.:.|:|     ...:|..:|...::    ..|...:..
Mouse  4210 RAAVTREDSGTYTCWAENRVGRVQAVSFVHVKE-----APVLQGEAFSYLVE----PVGGSIQLH 4265

  Fly  4518 AKVTGTRPLDVYWLKNGMKIQPSIKFKMLEEDSVHTLLIIEPFAEDSGRYECVAVNAAGEARCDG 4582
            ..|.|....|::|.|:|:.:..|.....|:..|   |.|:....:|:|||:|:|||..|..:
Mouse  4266 CVVRGDPAPDIHWTKDGLPLPISRLHFQLQNGS---LTILRTKMDDAGRYQCLAVNEMGTVK--- 4324

  Fly  4583 DCIVQSPSKPEKPTTPGSEKAPHIVEQLKSQTVEEGSKVIFRCRVDGKPTPTARWMRGENFVKPS 4647
                       |..|...:.||....:.:..||..|..|..|||..|:|.||..|:|....::..
Mouse  4325 -----------KVVTVVLQSAPVFQVEPQDVTVRSGVDVELRCRATGEPVPTIEWLRAGRPLQAG 4378

  Fly  4648 RYFQMSRQGEYYQLVISEAFPEDEGTYKCVAENKLGSIQTSAQLKVRPIENLDAPPTITALKDVS 4712
            |..:....|   .|.:......|.|.|:|||.|.|||:...|.|.||
Mouse  4379 RKLRALPDG---SLWLEHVEAGDAGVYECVAHNHLGSVTAKALLAVR------------------ 4422

  Fly  4713 VTEGMPAQFKTTVTGKVKATSVQWFREGQLIPETPDFQMIFDGNSAVLLIGTTYEEDSGIFTVRV 4777
               |.|...:.::||.:         .||      :|.|      |.|.|....:..|...|  :
Mouse  4423 ---GEPRGSRGSMTGVI---------NGQ------EFGM------ATLNISVLQQGSSEAPT--I 4461

  Fly  4778 TSSTGQVESS 4787
            .||..||.:|
Mouse  4462 WSSISQVPAS 4471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sls	NP_001261304.1	I-set	87..174	CDD:254352	25/82 (30%)
		Ig	109..175	CDD:143165	21/68 (31%)
		Ig	254..334	CDD:299845	21/81 (26%)
		I-set	255..344	CDD:254352	23/90 (26%)
		I-set	372..462	CDD:254352	26/137 (19%)
		Ig	390..463	CDD:299845	18/72 (25%)
		Ig	471..561	CDD:299845	30/89 (34%)
		I-set	471..560	CDD:254352	30/88 (34%)
		I-set	618..709	CDD:254352	30/109 (28%)
		Ig	645..705	CDD:143165	23/66 (35%)
		DUF1136	715..741	CDD:284093	3/25 (12%)
		IG_like	762..843	CDD:214653	18/82 (22%)
		Ig	779..835	CDD:143165	16/57 (28%)
		I-set	890..982	CDD:254352	29/93 (31%)
		Ig	918..979	CDD:143165	21/60 (35%)
		DUF1136	988..1014	CDD:284093	3/25 (12%)
		I-set	1024..1116	CDD:254352	24/94 (26%)
		Ig	1058..1113	CDD:143165	13/54 (24%)
		I-set	1158..1250	CDD:254352	23/91 (25%)
		Ig	1178..1246	CDD:143165	20/67 (30%)
		DUF1136	1256..1282	CDD:284093	2/25 (8%)
		I-set	1291..1380	CDD:254352	27/98 (28%)
		IGc2	1304..1372	CDD:197706	23/74 (31%)
		DUF1136	1388..1414	CDD:284093	3/25 (12%)
		I-set	1424..1515	CDD:254352	26/91 (29%)
		Ig	1442..1513	CDD:143165	21/71 (30%)
		DUF1136	1522..1548	CDD:284093	5/26 (19%)
		I-set	1558..1645	CDD:254352	26/86 (30%)
		IGc2	1571..1639	CDD:197706	21/67 (31%)
		DUF1136	1655..1679	CDD:284093	2/23 (9%)
		I-set	1691..1782	CDD:254352	23/96 (24%)
		IGc2	1718..1772	CDD:197706	16/53 (30%)
		DUF1136	1788..1814	CDD:284093	1/25 (4%)
		I-set	1824..1916	CDD:254352	23/91 (25%)
		IGc2	1838..1906	CDD:197706	20/67 (30%)
		DUF1136	1922..1948	CDD:284093	0/25 (0%)
		I-set	1958..2049	CDD:254352	26/114 (23%)
		Ig	1985..2044	CDD:143165	18/82 (22%)
		I-set	2089..2181	CDD:254352	25/145 (17%)
		IGc2	2103..2171	CDD:197706	18/115 (16%)
		DUF1136	2187..2213	CDD:284093	7/27 (26%)
		I-set	2222..2314	CDD:254352	25/91 (27%)
		IGc2	2236..2304	CDD:197706	22/67 (33%)
		DUF1136	2320..2346	CDD:284093	2/25 (8%)
		I-set	2356..2448	CDD:254352	25/91 (27%)
		Ig	2384..2445	CDD:143165	21/60 (35%)
		DUF1136	2454..2480	CDD:284093	6/25 (24%)
		I-set	2488..2580	CDD:254352	21/94 (22%)
		Ig	2516..2576	CDD:143165	16/59 (27%)
		I-set	2622..2714	CDD:254352	22/99 (22%)
		IGc2	2636..2704	CDD:197706	18/75 (24%)
		I-set	2754..2844	CDD:254352	22/90 (24%)
		Ig	2771..2840	CDD:143165	20/69 (29%)
		IGc2	2908..2974	CDD:197706	17/65 (26%)
		I-set	3029..3120	CDD:254352	22/126 (17%)
		Ig	3057..3116	CDD:143165	15/88 (17%)
		I-set	3130..3220	CDD:254352	29/133 (22%)
		Ig	3148..3219	CDD:143165	24/114 (21%)
		I-set	3263..3354	CDD:254352	17/90 (19%)
		I-set	3401..3493	CDD:254352	28/101 (28%)
		Ig	3429..3490	CDD:143165	20/66 (30%)
		I-set	3539..3630	CDD:254352	23/91 (25%)
		Ig	3556..3625	CDD:143165	20/69 (29%)
		I-set	3676..3767	CDD:254352	20/90 (22%)
IGc2	3690..3758	CDD:197706	18/67 (27%)
I-set	3811..3900	CDD:254352	25/113 (22%)
Ig	3828..3899	CDD:143165	23/95 (24%)
I-set	3954..4046	CDD:254352	22/91 (24%)
Ig	3963..4042	CDD:299845	21/78 (27%)
I-set	4092..4180	CDD:254352	20/87 (23%)
Ig	4102..4172	CDD:299845	17/69 (25%)
I-set	4394..4483	CDD:254352	22/88 (25%)
Ig	4411..4480	CDD:143165	19/68 (28%)
I-set	4497..4581	CDD:254352	22/83 (27%)
Ig	4519..4580	CDD:143165	20/60 (33%)
I-set	4604..4693	CDD:254352	29/88 (33%)
Ig	4621..4691	CDD:299845	24/69 (35%)
I-set	4702..4792	CDD:254352	18/86 (21%)
Ig	4702..4791	CDD:299845	18/86 (21%)
COG4372	4996..>5260	CDD:226809
I-set	6536..6622	CDD:254352
Ig	6554..6622	CDD:143165
Ig	6654..6725	CDD:143165
I-set	6743..6829	CDD:254352
Ig	6760..6829	CDD:299845
I-set	6841..6928	CDD:254352
Ig	6858..6927	CDD:143165
I-set	6942..7033	CDD:254352
IGc2	6957..7023	CDD:197706
I-set	7066..7157	CDD:254352
Ig	7084..7153	CDD:143165
IGc2	7224..7289	CDD:197706
Ehrlichia_rpt	14571..15030	CDD:118064
SH3_p47phox_like	16753..16807	CDD:212790
I-set	16841..16931	CDD:254352
Ig	16858..16931	CDD:299845
I-set	16965..17060	CDD:254352
IGc2	16978..17050	CDD:197706
I-set	17068..17152	CDD:254352
Ig_2	17078..17152	CDD:290606
IG_like	17170..17253	CDD:214653
Ig	17180..17250	CDD:143165
I-set	17260..17342	CDD:254352
IGc2	17274..17331	CDD:197706
I-set	17347..17432	CDD:254352
IGc2	17367..17423	CDD:197706
I-set	17437..17521	CDD:254352
Ig	<17468..17521	CDD:299845
I-set	17528..17611	CDD:254352
Ig	17553..17602	CDD:143165
I-set	17618..17708	CDD:254352
Ig	17635..17708	CDD:299845
FN3	17712..17791	CDD:238020
I-set	17813..17898	CDD:254352
Ig	17830..17894	CDD:143165
Ig	17922..17994	CDD:299845
FN3	17998..18090	CDD:238020
FN3	18098..18189	CDD:238020
FN3	18207..18298	CDD:238020
FN3	18307..18398	CDD:238020
Hmcn2	XP_006498564.1	vWFA	38..196	CDD:238119
		Ig	445..511	CDD:319273
		IG	525..605	CDD:214652
		I-set	609..693	CDD:369462	25/81 (31%)
		IG	707..783	CDD:214652	17/78 (22%)
		IG_like	793..876	CDD:214653	22/84 (26%)
		I-set	889..969	CDD:369462	15/79 (19%)
		Ig	992..1058	CDD:386229	17/69 (25%)
		IG	1076..1157	CDD:214652	28/82 (34%)
		Ig	1161..1242	CDD:386229	13/88 (15%)
		Ig	1262..1336	CDD:386229	26/81 (32%)
		I-set	1345..1429	CDD:369462	23/129 (18%)
		I-set	1449..1523	CDD:369462	24/74 (32%)
		IG	1553..1633	CDD:214652	26/111 (23%)
		IGc2	1654..1716	CDD:197706	19/66 (29%)
		Ig	1741..1819	CDD:386229	27/114 (24%)
		Ig	1839..1903	CDD:386229	25/94 (27%)
		I-set	1907..1986	CDD:369462	28/114 (25%)
		Ig_3	1998..2073	CDD:372822	19/81 (23%)
		Ig	2092..2179	CDD:386229	27/129 (21%)
		Ig	2183..2273	CDD:386229	23/132 (17%)
		Ig	2291..2367	CDD:386229	15/91 (16%)
		IGc2	2389..2451	CDD:197706	17/65 (26%)
		I-set	2476..2554	CDD:369462	28/108 (26%)
		I-set	2558..2650	CDD:369462	30/129 (23%)
		I-set	2668..2740	CDD:369462	21/87 (24%)
		Ig	2782..2859	CDD:386229	25/110 (23%)
		I-set	2876..2954	CDD:369462	24/124 (19%)
		I-set	2966..3046	CDD:369462	24/128 (19%)
		I-set	3050..3141	CDD:369462	20/97 (21%)
		Ig	3145..3233	CDD:386229	11/94 (12%)
		Ig	3256..3320	CDD:319273	15/64 (23%)
		Ig	3347..3422	CDD:386229	22/125 (18%)
		IG_like	3436..3511	CDD:214653	26/100 (26%)
		IGc2	3530..3592	CDD:197706	19/75 (25%)
		Ig	3614..3695	CDD:386229	21/120 (18%)
		I-set	3699..3786	CDD:369462	27/100 (27%)
		Ig	3789..3874	CDD:386229	13/84 (15%)
		Ig	3900..3967	CDD:319273	17/70 (24%)
		I-set	3974..4060	CDD:369462	29/130 (22%)
		Ig	4064..4151	CDD:386229	20/164 (12%)
		I-set	4155..4240	CDD:369462	22/88 (25%)
		IGc2	4259..4321	CDD:197706	20/64 (31%)
		I-set	4335..4421	CDD:369462	29/88 (33%)
		G2F	4423..4605	CDD:369383	18/72 (25%)
		FXa_inhibition	4664..4699	CDD:373209
		EGF_CA	4701..4744	CDD:311536
		EGF_CA	4746..4783	CDD:214542
		EGF_CA	4789..4829	CDD:214542
		EGF_CA	4896..4935	CDD:214542
		EGF_CA	4936..4974	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810