DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and SIGLEC1

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_075556.1 Gene:SIGLEC1 / 6614 HGNCID:11127 Length:1709 Species:Homo sapiens


Alignment Length:2283 Identity:436/2283 - (19%)
Similarity:701/2283 - (30%) Gaps:876/2283 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  1692 VFTMPVRDVRV-------------AENQAVHFEARLIPVGDPKLTVEWLRNGQPIEA--SNRTTT 1741
            :|:.|. ||.|             .:.|.|...|      ||||          :||  ..||..
Human    42 IFSFPA-DVEVPDGITAIWYYDYSGQRQVVSHSA------DPKL----------VEARFRGRTEF 89

  Fly  1742 MHDFGYVALN--MKYVNPEDSGTYTCR-----------------AVNELGQAVTSAS-------- 1779
            |.:..:...|  :|.:.|||||:|..|                 .|.|..:..|.||        
Human    90 MGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGT 154

  Fly  1780 ----------LIVQSKTSIQLETQ-------------------HEAAMHKIHQLEDHSR------ 1809
                      :.:|.:..:|.:.|                   |...:|.....:||.|      
Human   155 EVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219

  Fly  1810 ----YQRREEEEYTVTTAPVFVTKLIGPS--NLVEGQSAHYECRI-EPYPDPNLKVEWFHNGKPL 1867
                ::.:.|....|..||..|..|:.||  |::.|:.....|:: ..||..: .::|..:|..|
Human   220 SVANHRAQS
EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVS-SIKWLKDGVRL 283

  Fly  1868 STGHRFRTTYDFGFAALDILTVYAEDSGEYTCRVTNNLGEAIN-SIVLNVTSRSSIIHETQHEEA 1931
            .|    :|      ..|.:......|:|.|||:..|.:|..:: .|.|::               
Human   284 QT----KT------GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI
--------------- 323

  Fly  1932 LTKIQHLEDTSRFQRKTDEEQFHAERPQFGRPLRNAKVNEGAPVHLE---ATLI---PVNDPT-M 1989
                                 |.||          .:|:...|: ||   .||:   |...|: :
Human   324 ---------------------FMAE----------VQVSPAGPI-LENQTVTLVCNTPNEAPSDL 356

  Fly  1990 KVEWYCNGRPIQTGHRFKTTYDFGFVALDILYAHAEDTGTYMCKAKNAIGEAVTTCAVNVTANKT 2054
            :..||.|...::..|..         .|.:..|...|||.|.|:.:|..| :..:..|:|..|. 
Human   357 RYSWYKNHVLLEDAHSH---------TLRLHLATRADTGFYFCEVQNVHG-SERSGPVSVVVNH- 410

  Fly  2055 LDLDTLDAQRLEKIRQLETYAPPPKPVVEEKGQKPIFLTPLSNLEHLKEGEHAHLECRVEPINDP 2119
                                 ||..||:      ..||...:.|..:       |.|.|  :::|
Human   411 ---------------------PPLTPVL------TAFLETQAGLVGI-------LHCSV--VSEP 439

  Fly  2120 NLKIEWFCNGKQLPT-------GHRYRTTHDFGYVALDILYVYGEDTGTYICKATNQLGEAVNTC 2177
            ...:.....|..|.:       ..|:..|.....:.|:|..:...|:|.|.|.|||.||.|.:|.
Human   440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTL 504

  Fly  2178 NVRVLNRRSMILDTQHPDALEKIQKLESKVPNARTEVGDAPISPPHFTAELRGSTEIYEGQTAHF 2242
            :.             |.:|...:                  |||         :.|:.|||....
Human   505 DF-------------HANAARLL------------------ISP---------AAEVVEGQAVTL 529

  Fly  2243 EAQVAPVHDPNLRIEFYHNGKPL---PSASRFHITFDFGYVSLDITHAVAEDAGEYSVRAVNALG 2304
            ..:......|:.|..:|.||..|   |.:            ||.:..|.:.|||.|..||.:  |
Human   530 SCRSGLSPTPDARFSWYLNGALLHEGPGS------------SLLLPAASSTDAGSYHCRARD--G 580

  Fly  2305 QAVSSTNLRVIPRGTIISDTQHPEGLEKIRKLESTAPHQRQEPETPGTRQRPVFTQPLQNID--- 2366
            .:.|.      |....:....:|             |.|            |.||..| ::|   
Human   581 HSASG------PSSPAVLTVLYP-------------PRQ------------PTFTTRL-DLDAAG 613

  Fly  2367 -----------RINEHQTAHFEARLIPVGDPNLKVEWYRNEKIIEDS----------------SR 2404
                       |::              .||..:::....::::..|                .:
Human   614 AGAGRRGLLLCRVD--------------SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMK 664

  Fly  2405 ITKQHDFGFVSLDISHIRKEDEGVYMCRAVNPLGEAVTTASMRVVSEASIQMDTQHPDSISRIHQ 2469
            :||..:  .:.::|.:...|:||:|:|.|.|.||.|.|:|:..  .:|::               
Human   665 VTKAPN--LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN--GQATV--------------- 710

  Fly  2470 LEKPLAPRPTEPERLFEKPIFTQLLTGPSE-LWEGTHAHFEARV--VPVGDPSLKFEWFINGVEL 2531
                                   |...||. |.|||.|:....|  ...|.|: .|.||.|||..
Human   711 -----------------------LAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGVLW 751

  Fly  2532 QMGSRLRTTHDFGFVTLDITAVVPEDAGVYMCRAYNAAGEAVSSTAMKVKTKSNIDGQPLIPESW 2596
            ..|.         ..|:.:..|...||.:|.||....||..:|:..:     .::...|..|:..
Human   752 AQGP---------LETVTLLPVARTDAALYACRILTEAGAQLSTPVL-----LSVLYPPDRPKLS 802

  Fly  2597 EAIRLKEAAMNRVPEMF---VDSTPQQAPVFTTHLQSYDKLHEGQHVLLEAQVEPRADPNLRIEW 2658
            ..:.:.:..|    .:|   |||.|          .:...|..|:|:|..:.             
Human   803 ALLDMGQGHM----ALFICTVDSRP----------LALLALFHGEHLLATSL------------- 840

  Fly  2659 FKNGISLTTGSRIRSTFDFGLVTLSINGLRADDSAIYTCKATNQVGEAVSTSSLKIEDR-HWLQA 2722
               |..:.:..|.::..:...:.|.:..|...||..|.|:|||.:|.  |.:||..:.| .|:|.
Human   841 ---GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGS--SNTSLFFQVRGAWVQV 900

  Fly  2723 ESLHPDSLPRIGELEAPKEGRPEAPEPTYETPVFITHLNNIECKESDNVRFECNVEPARDPTMSI 2787
                                   :|.|              |.:|...|...|.|........|.
Human   901 -----------------------SPSP--------------ELQEGQAVVLSCQVHTGVPEGTSY 928

  Fly  2788 EWFYNGQPLQAAAKFKSIYDFGYCALDLTNSYAENSGVYTCKATNSKGSATTSGTLKCTGGKTMF 2852
            .|:.:|||||.:..    ....:.|:.||     .:|.|.|:| .:.||||||            
Human   929 RWYRDGQPLQESTS----ATLRFAAITLT-----QAGAYHCQA-QAPGSATTS------------ 971

  Fly  2853 LDTQHPQGEAGLEAVQETEEELANRYTSKTTKPET------------QYPPPVWTKPLQAEFHLS 2905
                       |.|........|.|:.:.||..:|            ...||...:.|..:..::
Human   972 -----------LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025

  Fly  2906 EAQPIHLEANVEPK-EDPNLFIEWYFNGKMLN-HGSRFKMTSEFGFVTMDMIEVYARDQGIYTCK 2968
            ..    |:....|: ..|.|.:....|...|. ||:              |:|    |:|:|.|:
Human  1026 ST----LQGVGGPEGSSPRLHVAVAPNTLRLEIHGA--------------MLE----DEGVYICE 1068

  Fly  2969 AYNKAGEAFTSTTIFCSSKENIIESTQHPKGAEGLEQIQDLEDSLRKDGSKPEQPDLGIPPRFTT 3033
            |.|..|:|..|..                                                 |..
Human  1069 ASNTLGQASASAD-------------------------------------------------FDA 1084

  Fly  3034 EFVNI-----ADIGEGELAHFEANLIPVGDQSMVIEWFYNGKVLEASHRVRTIYAFGTVALEVLG 3093
            :.||:     |.:.||:|.:....:.......:...|:.:|:....:|           ::.:..
Human  1085 QAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH-----------SIPLPN 1138

  Fly  3094 TKIEDTGTYTCRATNKHGTAEIS--CNLECVDKPRGQKPRF--TSHIQPLEGLKDGQSAHFECTL 3154
            ..:.|..:|.|..........:|  ..|:.:..||..:..:  .||        .||.|...||:
Human  1139 VTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESH--------GGQLALVLCTV 1195

  Fly  3155 IPVNDPDLKVEWYHNGKLMRHSNRIKTVSDFGYVVLDISYLQDHDSGEYVCRAWNKYGEDFTRTT 3219
              .:.|..::...|.|:|:..|......:.   :.|::...|..|.|.|.|.|.:..|:..|...
Human  1196 --DSRPPAQLALSHAGRLLASSTAASVPNT---LRLELRGPQPRDEGFYSCSARSPLGQANTSLE 1255

  Fly  3220 LNCGGRGGVFYDSLQPDSLQRIRELECPQGQQADTSAPLV---AEPPKFITQIVDVTKLVEGQSA 3281
            |.                |:.:|.:..|:....: .||:.   |:|                 :|
Human  1256 LR----------------LEGVRVILAPEAAVPE-GAPITVTCADP-----------------AA 1286

  Fly  3282 HFEARLTPITDPDLVVEWYFNGKKLPHGHRFRTFHDFGIVILDILYCYEENSGVYEARARNKYGE 3346
            |.....|          ||.||:.|..|         ....|..|.....::|.|..:|::..| 
Human  1287 HAPTLYT----------WYHNGRWLQEG---------PAASLSFLVATRAHAGAYSCQAQDAQG- 1331

  Fly  3347 DVTRASLKCASKSSLILDSQLPRGMEGGLEKIANLEYSMVRTREETTEETKGKAPVFTVPLENIE 3411
              ||:|...|.:                                           |...|.:.:.
Human  1332 --TRSSRPAALQ-------------------------------------------VLYAPQDAVL 1351

  Fly  3412 NLREGENAHFEARI--TPADDPKLKVEWYWNGRPLKAGSRFRTFCD-FGFV-------ILEISPV 3466
            :......|...|.|  |...:|..::....:|:.|...|...:... .|.|       .|::..|
Human  1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416

  Fly  3467 YPEDSGEYSCRAINEYGEAVTTATMKIQGKRSIIMESQLPKGMEGTIDRIAELEGLGSRSTEFVP 3531
             |.....|.|.|.|..|...|...::::|.| ::.|..|.                       ||
Human  1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGAR-VVAEPGLD-----------------------VP 1456

  Fly  3532 DDDTGKPPEFITSPFDMVIGENALAHFECRL----QPINDPSMRVDWFHNGKALWAGSRIKTIND 3592
                                |.|..:..|||    .|:.:.:..  ||.|.:.|.|    :.:..
Human  1457 --------------------EGAALNLSCRLLGGPGPVGNSTFA--WFWNDRRLHA----EPVPT 1495

  Fly  3593 FGFVILEIAGCYQRDSGLYTCKATNKHGEATVSCKLQVKGRQGIVMEPQLPS------------- 3644
            ..|..:..|     .:|:|.|.|....| |..|..:.::    ::..|:.|:             
Human  1496 LAFTHVARA-----QAGMYHCLAELPTG-AAASAPVMLR----VLYPPKTPTMMVFVEPEGGLRG 1550

  Fly  3645 --NFRTGTESLQKLEETMHKREELVTEDEQPNPPKFTEEIKDNLDVPEGGPIHFDCRVEPVGDPT 3707
              :.|..:|.|..|  |:|....||...:                 |:|.|      .||     
Human  1551 ILDCRVDSEPLASL--TLHLGSRLVASSQ-----------------PQGAP------AEP----- 1585

  Fly  3708 MRIEWFYNGHVMATGSRVHQLNDFGFIALDVDYIYARDSGEYTCRATNKWGTATTSAKVTCKGKH 3772
                            .:|.|.....:.:|::.:...|.|||.|.|:|..|:|:||.....:..|
Human  1586 ----------------HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALH 1634

  Fly  3773 NIVYESQL 3780
            .:....||
Human  1635 RLHQFQQL 1642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352 31/141 (22%)
IGc2 1718..1772 CDD:197706 20/74 (27%)
DUF1136 1788..1814 CDD:284093 7/54 (13%)
I-set 1824..1916 CDD:254352 25/95 (26%)
IGc2 1838..1906 CDD:197706 16/68 (24%)
DUF1136 1922..1948 CDD:284093 0/25 (0%)
I-set 1958..2049 CDD:254352 22/97 (23%)
Ig 1985..2044 CDD:143165 14/59 (24%)
I-set 2089..2181 CDD:254352 24/98 (24%)
IGc2 2103..2171 CDD:197706 17/74 (23%)
DUF1136 2187..2213 CDD:284093 2/25 (8%)
I-set 2222..2314 CDD:254352 22/94 (23%)
IGc2 2236..2304 CDD:197706 19/70 (27%)
DUF1136 2320..2346 CDD:284093 3/25 (12%)
I-set 2356..2448 CDD:254352 24/121 (20%)
Ig 2384..2445 CDD:143165 17/76 (22%)
DUF1136 2454..2480 CDD:284093 0/25 (0%)
I-set 2488..2580 CDD:254352 28/94 (30%)
Ig 2516..2576 CDD:143165 19/59 (32%)
I-set 2622..2714 CDD:254352 19/91 (21%)
IGc2 2636..2704 CDD:197706 14/67 (21%)
I-set 2754..2844 CDD:254352 25/89 (28%)
Ig 2771..2840 CDD:143165 21/68 (31%)
IGc2 2908..2974 CDD:197706 16/67 (24%)
I-set 3029..3120 CDD:254352 14/97 (14%)
Ig 3057..3116 CDD:143165 6/58 (10%)
I-set 3130..3220 CDD:254352 21/91 (23%)
Ig 3148..3219 CDD:143165 17/70 (24%)
I-set 3263..3354 CDD:254352 18/90 (20%)
I-set 3401..3493 CDD:254352 21/101 (21%)
Ig 3429..3490 CDD:143165 15/68 (22%)
I-set 3539..3630 CDD:254352 20/94 (21%)
Ig 3556..3625 CDD:143165 17/72 (24%)
I-set 3676..3767 CDD:254352 19/90 (21%)
IGc2 3690..3758 CDD:197706 14/67 (21%)
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
SIGLEC1NP_075556.1 Ig 21..136 CDD:299845 26/110 (24%)
IG_like 26..135 CDD:214653 26/109 (24%)
Sialic acid binding. /evidence=ECO:0000250 122..126 0/3 (0%)
C2-set_2 142..228 CDD:285423 11/85 (13%)
Ig_2 245..323 CDD:290606 22/88 (25%)
IG_like 247..323 CDD:214653 22/86 (26%)
Ig 336..408 CDD:299845 21/82 (26%)
IG_like 338..408 CDD:214653 20/79 (25%)
Ig 430..503 CDD:143165 20/81 (25%)
IG_like 431..503 CDD:214653 20/73 (27%)
Ig_2 514..594 CDD:290606 26/126 (21%)
IG 516..594 CDD:214652 25/106 (24%)
IG_like 624..703 CDD:214653 18/94 (19%)
IG_like 715..792 CDD:214653 27/91 (30%)
ig 715..788 CDD:278476 27/82 (33%)
Ig 809..893 CDD:299845 25/115 (22%)
I-set 898..980 CDD:254352 30/151 (20%)
Ig_2 900..980 CDD:290606 29/149 (19%)
Ig 1003..1080 CDD:143165 21/98 (21%)
Ig_2 1093..1168 CDD:290606 12/85 (14%)
IG_like 1093..1168 CDD:214653 12/85 (14%)
I-set 1186..1256 CDD:254352 19/74 (26%)
Ig_2 1263..1342 CDD:290606 24/161 (15%)
IG_like 1271..1342 CDD:214653 23/153 (15%)
Ig 1363..1442 CDD:299845 18/79 (23%)
IG_like 1455..1529 CDD:214653 22/109 (20%)
Ig 1457..1518 CDD:299845 17/71 (24%)
Ig <1552..1630 CDD:299845 27/123 (22%)
IG 1552..1627 CDD:214652 27/120 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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