DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and vwf

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_001268918.1 Gene:vwf / 570643 ZFINID:ZDB-GENE-070103-1 Length:2812 Species:Danio rerio


Alignment Length:1900 Identity:332/1900 - (17%)
Similarity:562/1900 - (29%) Gaps:666/1900 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly 16892 DDDNVATLIIREVFPEDAGQFTVVAKNAAGFTSS---TTELIVESPLSDHGSDATALSRRSMSRE 16953
            |.|....:::| :.|..|||...:..|..|....   |...:||:.:...|:        |....
Zfish   494 DWDGRGRVLLR-LKPAYAGQMCGLCGNYNGNQGDDFLTVGGLVETRVEAFGN--------SWKMN 549

  Fly 16954 SSLADI-LEGIPPTFSKKPKAQYVDENTNVILE-----CRLVAVPEP-------DIVWTFNGEDI 17005
            :...|: ::...|......:.::.:|...|:|.     |..:..|||       |:....:|::.
Zfish   550 ADCDDVQMQNSDPCSLNPKRVRFAEEACAVLLSMKFEPCHYMVNPEPYVKNCRYDVCACADGQEC 614

  Fly 17006 DEEEIKNVRIVTES-------DMHMYCSVVHISKVKKSQEGTYEVIATNREGEAR---LPITLKV 17060
            ..:.:.:..:...:       ..|.||.:.    ...:|  .||:..:......|   ||     
Zfish   615 LCDAVSSYAVACAARGVLVNWRSHGYCELT----CPDAQ--VYEMCGSVCNQTCRSLSLP----- 668

  Fly 17061 RTTDKEAPQILE-----PLRNMVIREGESVVLSTQIVGNPPPKVTWYKDGKPVKNAKSDKDLHTL 17120
               |.....:.|     |....:...||.|         ||...:.:.:|:..:......|.|::
Zfish   669 ---DTGCDGVCEEGCFCPRGLFLSDAGECV---------PPQHCSCHHNGEIFEPNDMIGDHHSI 721

  Fly 17121 TLITPQKSEKGEYTVKAVNPLGSVETTANLTIEEPAGGNAEPPLFVERFEEQNVPQKGEIRLPAK 17185
                            .|...||:..|:|     .|.|:....||   |:||: |.:|...|...
Zfish   722 ----------------CVCESGSMHCTSN-----EATGSTLSDLF---FDEQS-PSRGRRSLSCP 761

  Fly 17186 VSGNPVPEVQWLFNNTPLFPSERIQQVYDGENIELIIKDANPETDSGDYKCIAS--NPIGKTSHG 17248
                  |.:|       .|..|..:..    .||......|.|.|.....|::.  .|.|...:.
Zfish   762 ------PPLQ-------RFECESARDA----GIECAKTCQNLELDCVSLGCVSGCMCPPGTVRYR 809

  Fly 17249 ARVIVEVDEVTFTKKLKKTITIEEVQSLTLECETSHVVTTKW--------------------FFN 17293
            ...|.:.....:    ..:...|..||:|::|.|......:|                    .|:
Zfish   810 KDCIPQEQCPCY----HNSRPYESGQSITVDCNTCVCEQRQWKCSERVCDGVCRAIGDTHYISFD 870

  Fly 17294 GKELS--GMDHRVVVED-----GKTHKLVIRNTNLRDSGTYTCKVKKQETQSTV----------- 17340
            |.:.|  |....|:.:|     ..|.::::.|:....:| |.|     ....||           
Zfish   871 GLKFSFPGPCQYVLAQDYCNGLDGTFRVLVENSACGIAG-YRC-----SKSITVLYMGGLIVMEH 929

  Fly 17341 -EVLQRKPDFIKVLEDYEVTEKDTAILDVELTTEATEVTWYKDGEKITPENKNVEFIKDGKARRL 17404
             ||..::|    ||::.||....:.:..:.|..:...:||                  |...|  
Zfish   930 GEVRMKRP----VLKETEVEIVRSGLYYIVLLGKHISITW------------------DTGTR-- 970

  Fly 17405 VIRDVTIHDEGQYTCKI-------EGQECSCELVVIELPPEIVEPLNDVAVTKGENAVFEVELSK 17462
                :::...|||..|:       :|.:                 .||:..:..     ::|:..
Zfish   971 ----ISLQISGQYRGKVCGLCGNFDGSQ-----------------NNDLLSSSN-----QMEVDA 1009

  Fly 17463 GDALVKWFKNGKEIVFNERIQLAIDGKKQSLRIVKAKPEDVGEYSVQVGEQTSKAKL-TVEEPLV 17526
            .|....|                           |.:|......||.....|...|| |||:.  
Zfish  1010 ADFGNSW---------------------------KVRPSCADAVSVVSQCSTDLVKLVTVEQS-- 1045

  Fly 17527 DFVIRLPDITLATKTTDAEFTVQLSQPDVEVTWCKKGKPIKPNQKHEVFVEGTVRRLVIHDASDE 17591
                       ....|.|.|....|..|.|..|             ::..:.|        .|..
Zfish  1046 -----------CRVLTSAIFRDCNSVVDPEPYW-------------DICTQDT--------CSCP 1078

  Fly 17592 DAGEISCVAENVTSSTKLCVEELKLPPVITSDKDQTIKVKEND-------DVTFTVKYTGV---- 17645
            ..|:.:|....:.:....|.:           |...:..:.||       |:.   |.:||    
Zfish  1079 SVGDCACFCNTIAAYAHECAQ-----------KGLPVNWRSNDLCPLSCEDLN---KESGVQCEW 1129

  Fly 17646 -------PTPEACWTTRKVVIPKS-----KRTIP---TIDEQSAKLTIKKVVDDDEGEYTVK--- 17692
                   ..|..|.....:..|.|     ....|   .:||     .::|.|:..:.:..|.   
Zfish  1130 RYNTCASACPSTCQHPEPLSCPISCVEGCHAVCPPGHLLDE-----VLRKCVEPSQCQVCVHDGQ 1189

  Fly 17693 --------LVN----------------------PV-GEAEASLHLVIMRKPTAPGTPQPLEIMHD 17726
                    ::|                      || |.........:...|....||.|.:....
Zfish  1190 RVSHGKQFILNHEDPRLCQICHCESNTLTCGPCPVTGLTSTLAPTTVTPTPLPFSTPVPADACDR 1254

  Fly 17727 SITLYWKAPEDDGKSEIIE--------YIL------------------------EYQDVKEEKWT 17759
            ::.|.:..   ||.|.:.|        :||                        :..|::.:||.
Zfish  1255 AMDLAFLV---DGSSALSEDDFSMIKLFILRVVERFRMGSAHTRATVLLFHSGVKSYDMQVQKWI 1316

  Fly 17760 EIRKIKDTTYT-------ISKLKIDTEYVFRS--------IAVNEVGPSPPSPLSPPIRLVPKVE 17809
            ..:.:::..||       ...:|....|::..        :|:.....:.|.|:....||:.|.:
Zfish  1317 FKKMVREMRYTGGDVAFMDEAIKYLAVYIYDKNKREHAGRVAILLTASANPRPMRSTQRLLRKKD 1381

  Fly 17810 --------------------TKA-PSVQEPLQDVVSELDKEVTLS-----CVFGGIPEPKVTWKK 17848
                                ||| ||.:..:...|:|||.| .||     |..|..|||:   ||
Zfish  1382 ITILTVALGPDVNMAQVNEITKATPSSRAYVVSSVTELDDE-ALSITDYLCTLGLDPEPQ---KK 1442

  Fly 17849 NGQVFESRS--IRYENRVAKYTIEKTTI-----------------ETEATYTCV-------ATNE 17887
            ......|.:  ....|.:.|.||..|..                 .|..||..|       ||.|
Zfish  1443 PPTAKPSTTSVTPTTNAITKLTIPPTAAIVTAFPSIPTPGTTLVPTTVTTYDLVFLLENANATGE 1507

  Fly 17888 KGSAETSCRL-----KLQQKPVLEVEDKYLTQKLRTGSILTIPATVRGYPQPTVTWHKETIEQKT 17947
            .|..:|...|     .|.||   |.|:..:|       ::....||..........|:|.:.|:.
Zfish  1508 DGFNKTRDSLINIITSLDQK---EAENLRIT-------VMMYSVTVTVEISRMELHHREQVVQRM 1562

  Fly 17948 TKSVTIETTETTSTYTVKKVTREQSGKYKVTATNESGTTYVECTVQVIDKP-----SRPQSLEIK 18007
            .:....|..|..:.:.|:.|       |:...|:....|..:....:...|     .||.|...|
Zfish  1563 RQLRWTEGAEVNTGHAVQSV-------YETITTDTHSDTPDQLVFLITQSPPTDVIQRPPSSTHK 1620

  Fly 18008 DI----------KKDSIVLEW--TPPVDDGGLDIEKYTLEKCDVQNNVWMKVSDFNKDIKSYAVQ 18060
            .|          .:|..:|.:  .|.:.|...|:.  ||:.         .:.:.::.::...:.
Zfish  1621 KIYPIGIGRKIRYEDLALLSFPDKPIMLDDPSDLR--TLQP---------MLINISRTVRRPLLP 1674

  Fly 18061 KLSMNAQYMFRVVAANPI-------GESEPTESDPVTITKKFEKPSPPRGPTTVSGMNDT----- 18113
            .|...|.....|..:.|:       ..|.....|..|..|.|.|       :|..|.|||     
Zfish  1675 TLPPRATLPPSVPCSKPMDVLFLLRASSGSQFEDLKTFVKTFIK-------STNIGRNDTQVAVM 1732

  Fly 18114 ------SFNLAWEPSET-DGGSKIIEYI-----------VEIREETETTYRSV-GVTLG------ 18153
                  :..:.|...:| |...|::|.:           ..:|...:|...|. |..:|      
Zfish  1733 VYGAKSAVAVTWRDEQTQDNLLKLLESLHGKTDNQPRLGAALRLAVQTAVSSTSGARMGIPKAVV 1797

  Fly 18154 -TVTNIHVEKVVRNKGYFFRIYARNEVGTSEAFETTEKIVLGRKITN-DNEALAPPSPPQN---L 18213
             .||:..::.|..         |.||..|  |..:...|.||::... :...||.|...:|   |
Zfish  1798 MVVTDRSIDSVQE---------AANEALT--AGVSVFPIGLGKQYDQIEVNTLAGPQAQENVILL 1851

  Fly 18214 RAPDVTSRSVTLDWEVPARNGGSEITGYCVEKRS----------------STSTNWTKVITLDAH 18262
            .:.:........|...|.:...:...|.||:...                |...|.:..||:.:|
Zfish  1852 GSTEYLLSMAAFDQSFPDKLCRAGPPGVCVDDEGNERKPGETWMLADGCHSVLCNPSGTITMQSH 1916

  Fly 18263 QLHYTIDNLKEKCEYWFRVSAENEVGLGAPAVTESISLKTHATVPSPPTGPLEARVLAANAHIFE 18327
            :::         ||.......:|.:    ||:..:.......|.|....|       ::.:|:..
Zfish  1917 RIN---------CEKMEPPVCKNNL----PALRYNHHCGCTWTCPCSCMG-------SSTSHVVS 1961

  Fly 18328 WG------------LPESDGGAPLL-----------------------GYHIAIR-DMKKTMWIE 18356
            :.            |....|||.|:                       |..:.:: |||.|:...
Zfish  1962 FSGAALKVKSACSYLLLRSGGAELVLHTTACQSSPNQICMKSLELREGGTSVVLQDDMKVTVGGV 2026

  Fly 18357 VGRVP----------AGVLKFQIRDLQ---------ENHEYMIRI---FAKNEIGLSEPLESEEP 18399
            :..||          .|.:..|:|..|         .::|:|:.:   ...|..||......::.
Zfish  2027 LTAVPFRTERVTVTQIGSILHQLRSEQHGFTLTFTPHSNEFMLNMDIAMKPNTTGLCGSCSDDQS 2091

  Fly 18400 YKAMTAGHESLPDEP 18414
            ...::.|  |:..:|
Zfish  2092 GLLLSDG--SVTTDP 2104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352 10/41 (24%)
Ig 16858..16931 CDD:299845 10/41 (24%)
I-set 16965..17060 CDD:254352 19/116 (16%)
IGc2 16978..17050 CDD:197706 15/90 (17%)
I-set 17068..17152 CDD:254352 15/88 (17%)
Ig_2 17078..17152 CDD:290606 13/73 (18%)
IG_like 17170..17253 CDD:214653 17/84 (20%)
Ig 17180..17250 CDD:143165 13/71 (18%)
I-set 17260..17342 CDD:254352 20/120 (17%)
IGc2 17274..17331 CDD:197706 17/83 (20%)
I-set 17347..17432 CDD:254352 15/91 (16%)
IGc2 17367..17423 CDD:197706 9/62 (15%)
I-set 17437..17521 CDD:254352 12/84 (14%)
Ig <17468..17521 CDD:299845 8/53 (15%)
I-set 17528..17611 CDD:254352 11/82 (13%)
Ig 17553..17602 CDD:143165 7/48 (15%)
I-set 17618..17708 CDD:254352 21/149 (14%)
Ig 17635..17708 CDD:299845 18/125 (14%)
FN3 17712..17791 CDD:238020 19/125 (15%)
I-set 17813..17898 CDD:254352 32/120 (27%)
Ig 17830..17894 CDD:143165 23/94 (24%)
Ig 17922..17994 CDD:299845 12/71 (17%)
FN3 17998..18090 CDD:238020 19/115 (17%)
FN3 18098..18189 CDD:238020 23/121 (19%)
FN3 18207..18298 CDD:238020 18/109 (17%)
FN3 18307..18398 CDD:238020 24/148 (16%)
vwfNP_001268918.1 VWD 29..167 CDD:278521
C8 <227..284 CDD:214843
TIL 288..341 CDD:280072
VWC 343..>387 CDD:302663
VWD 381..534 CDD:278521 10/40 (25%)
C8 573..641 CDD:285899 10/67 (15%)
TIL 645..700 CDD:280072 14/73 (19%)
TIL 760..818 CDD:280072 13/74 (18%)
VWD 847..1003 CDD:214566 33/206 (16%)
C8 1043..1112 CDD:285899 16/113 (14%)
TIL 1131..1181 CDD:280072 9/54 (17%)
VWA_N2 1183..>1222 CDD:292782 2/38 (5%)
VWA 1257..1421 CDD:278519 28/166 (17%)
vWFA_subfamily_ECM 1493..1628 CDD:238727 32/151 (21%)
VWA 1693..1848 CDD:278519 35/172 (20%)
VWD 1939..2091 CDD:214566 25/158 (16%)
C8 2131..2194 CDD:285899
CT 2731..2808 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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