DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and NEFM

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_005373.2 Gene:NEFM / 4741 HGNCID:7734 Length:916 Species:Homo sapiens


Alignment Length:1101 Identity:243/1101 - (22%)
Similarity:421/1101 - (38%) Gaps:279/1101 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  4895 GFKPEPVKSWTEETINLKATPIEKKKPAPKLEAAKVVLKSIKTERDQGIMSLGATL--------- 4950
            ||:.:   ||:..:.:..::..::...||:|..:..:|.|.::..|   .|..::|         
Human    34 GFRSQ---SWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLD---FSQSSSLLNGGSGPGG 92

  Fly  4951 EQIIAGKTEKEAIPWITMR-----EKL-------KAVESV-----QQQLNKFDLDEVY---LQPL 4995
            :..::...|||.:..:..|     ||:       |.:|:.     |:|.:...|.:.|   ::.|
Human    93 DYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157

  Fly  4996 EGQIETEGQLPQQAQVEQVQRTKEIQRLKSMESVEIMEMTDQIDKLITQQQNAKDLIPWKEMRQQ 5060
            ...:|.......|.|::.....::|.|||.....| ..:.|..:..|            :.:|:.
Human   158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEE-ARLRDDTEAAI------------RALRKD 209

  Fly  5061 LKSVQRVTKQIDKFKI----EEVELRHLQAQQAITEEYQTGTAEETVVMIDESSKGSISKVLR-- 5119
            ::....|..::|| |:    :||.......::.:.:......|....|...:..|..||..|:  
Human   210 IEEASLVKVELDK-KVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEI 273

  Fly  5120 RDEQLQYEDQSNIYKQKFITTEDVNIMHVSEREKLEAQRLIREQQAVNWRQQQQRPQLQPLTSVE 5184
            |.:...:.||:....:::.......:...:|:.| ||.|..:|:.| .:|:|.|...:: |.||.
Human   274 RSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNK-EAIRSAKEEIA-EYRRQLQSKSIE-LESVR 335

  Fly  5185 DTVISQTSERQKLVQQQSFIEEAQRQQFVQVEDSQMMSLEEYEHQKIINQRTQQEAFSWRQPREP 5249
            .|       ::.|.:|.|.|||.........:|    ::::.|:        :.....|...|..
Human   336 GT-------KESLERQLSDIEERHNHDLSSYQD----TIQQLEN--------ELRGTKWEMARHL 381

  Fly  5250 QKFIQVEDSTLLHLQERHDTQ---EQQLLQQQPVMWDRGRKKPDQPQYVQPQEQRVKEEFVEKPK 5311
            :::     ..||:::...|.:   .::||:.:...:.........|.|.......:..: ::|||
Human   382 REY-----QDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSK-IQKPK 440

  Fly  5312 TYEEMHDELVEPTPIEQPQPVPVMWERGKKKPQPQEKTFEEAHDELVEPTPVQQPEPVPVMWERG 5376
                          :|.|            |.:.|.|..|    |::|.|.|          |..
Human   441 --------------VEAP------------KLKVQHKFVE----EIIEETKV----------EDE 465

  Fly  5377 KKKVAQQETVLSQEVVQTSQVVEQQIVEETKKTAVRRVIPPREPEQKVEQVTLKPTPRPRPKEAV 5441
            |.::.:..|.:::|:..:.:..:::..||.::          |||.:.|:|..|.:|       |
Human   466 KSEMEEALTAITEELAVSMKEEKKEAAEEKEE----------EPEAEEEEVAAKKSP-------V 513

  Fly  5442 KAEEIQLKPLRSTRPVPQPVEAEQKAYEEATDELTEEPIPQPQPVMWERGKKKPQKPQEEVTEIP 5506
            ||...::|.           |..:|..||..:|..||..........|.|.:|....::|..|  
Human   514 KATAPEVKE-----------EEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE-- 565

  Fly  5507 KTLEIAVDTLEEEVPKPTEPQPQPVLWARGQ----KKPQKPDEQKQELPKSLEIAVDTIEEDLIK 5567
                      :||.....|        |.|:    |:.:|.:|:.:|:....|:..|...|...|
Human   566 ----------QEEGETEAE--------AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEK 612

  Fly  5568 PVQPEPQ-PVLWERKKKKPQPQDVIEEKLDVAPTKTYEKAVDVLPDEPKVEEKPEPVLWQRGKKK 5631
            ...|.|: ||  |.|.|.|.|:..:|           ||....:|..| ||||        ||..
Human   613 AKSPVPKSPV--EEKGKSPVPKSPVE-----------EKGKSPVPKSP-VEEK--------GKSP 655

  Fly  5632 IPKSEPTEEVHPDEVDAQIETVVKEDEMIVEEKRRIKKTKRP----KSTKEVTEELFEEQPEEEI 5692
            :||| |.||.....|          .:..||||.:....|.|    ||..||.:   .||.|||.
Human   656 VPKS-PVEEKGKSPV----------SKSPVEEKAKSPVPKSPVEEAKSKAEVGK---GEQKEEEE 706

  Fly  5693 SPEEEVPQKEVIEEIEEIVEEKRRLKKTKKPKLTQQVTEEETPHEEIIKESEEVVQEQ--EEIVE 5755
            ...:|.|::|.:|            ||.:|||        :.|.:   |::|..|:|:  .|:|.
Human   707 KEVKEAPKEEKVE------------KKEEKPK--------DVPEK---KKAESPVKEEAVAEVVT 748

  Fly  5756 EKKKVKKVKKPKTVAEKQLKEEEIPTEETVEEEETAEDQQLVVEESKKVKKVKKPTGTVEKTDVE 5820
            ..|.|      |...||:.|||..|.::..|:|:...:.....|.|.|..|..:      |.|:.
Human   749 ITKSV------KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR------KEDIA 801

  Fly  5821 ---ELPGEEVPVEEVPVEEVPEDVAPEEELIEEQEEIV----DQDEIQEQKRKVKKAKK--PKKT 5876
               |:.|:         |||.::...:....||::.:|    |.....|:|...|..:|  ..||
Human   802 VNGEVEGK---------EEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKT 857

  Fly  5877 IEKTEIEIEEDQPE---EEVLQEEIIGEQEEITERQRKVKSIKKPKKVVTEKTVDQTEQPE 5934
            :||...|..:...:   :.|...:.:.|.||..|  .|:.|.||.:||.:...|.:..|.:
Human   858 VEKITSEGGDGATKYITKSVTVTQKVEEHEETFE--EKLVSTKKVEKVTSHAIVKEVTQSD 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809 50/269 (19%)
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
NEFMNP_005373.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 4/19 (21%)
Head 2..104 14/75 (19%)
Filament_head 10..78 CDD:282575 10/49 (20%)
Filament 100..411 CDD:278467 68/351 (19%)
Coil 1A 105..136 5/30 (17%)
Linker 1 137..149 3/11 (27%)
Coil 1B 150..248 19/111 (17%)
Linker 12 249..265 3/15 (20%)
Coil 2A 266..287 6/20 (30%)
Linker 2 288..291 0/2 (0%)
Coil 2B 292..412 29/146 (20%)
Tail 413..916 163/673 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..851 125/493 (25%)
6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK] 614..691 33/109 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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