DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and MYLK

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:XP_024309300.1 Gene:MYLK / 4638 HGNCID:7590 Length:1924 Species:Homo sapiens


Alignment Length:2216 Identity:462/2216 - (20%)
Similarity:755/2216 - (34%) Gaps:703/2216 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  3366 QLPRGMEGGLEKIANLEYSMVR-----TREETTEETKGKAPVFTVPLENIENLREGENAHFEARI 3425
            |||:...|.::.:|:...|...     :|.::...|  :||.|.:|..|: .::||..|.||.|:
Human     5 QLPKQTMGDVKLVASSHISKTSLSVDPSRVDSMPLT--EAPAFILPPRNL-CIKEGATAKFEGRV 66

  Fly  3426 TPADDPKLKVEWYWNGRPLKAGSRFRTFCDF-GFVILEISPVYPEDSGEYSCRAINEYGEAVTTA 3489
            ....:|  :|.|:.||:|:.:|.||...|.. |...|.|..|:.||.|:|:|.|.|..|....|.
Human    67 RGYPEP--QVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTV 129

  Fly  3490 TMKIQGKRSIIMESQLPKGMEGTIDRIAELEGLGSR----STEFVPDDDTGKPPEFITSPFDMVI 3550
            .:.::|.    ...||.:.:..        :.||.|    :.|..|......||:|.|....:|:
Human   130 ELTVEGS----FAKQLGQPVVS--------KTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVV 182

  Fly  3551 GENALAHFECRLQPINDPSMRVDWFHNGKALWAGSRIKTINDFGFVILEIAGCYQRDSGLYTCKA 3615
            .|..:..|.|::  ...|..:|.|......|...:|:......|..:|||.|..|.|.|:|||..
Human   183 KEGQMGRFSCKI--TGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLV 245

  Fly  3616 TNKHGEATVSCKLQVKG----RQGIVME------------------------------------- 3639
            .|..|:|::|.:|.::|    .:..|.|                                     
Human   246 VNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSP 310

  Fly  3640 -------------PQLP--SNFRTGTESLQKLEET--MHKREELVT------------------- 3668
                         ||.|  |...:..:|.:...:|  :.|....:|                   
Human   311 QRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLS 375

  Fly  3669 ----EDEQPNP-------------------------------------PKF-----TEEIKDNLD 3687
                |.::|.|                                     |||     ::|:|:|..
Human   376 PSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQT 440

  Fly  3688 VPEGGPIHFDCRVEPVGDPTMRIEWFYNG-HVMATGSRVHQLNDFGFIALDVDYIYARDSGEYTC 3751
            |      .|.|.|.  |.|...:.||..| .|......:....|.|...|.:.....||||.|:|
Human   441 V------KFRCEVS--GIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSC 497

  Fly  3752 RATNKWGTATTSAKVTCKGKHNIVYESQLPEGMTSEKLKELERGRIPEAPKVVEEVFGPPKFTTQ 3816
            .|:|..|..:.|..:                        ::||..:.|.         .|.|::.
Human   498 TASNAQGQLSCSWTL------------------------QVERLAVMEV---------APSFSSV 529

  Fly  3817 ITSVTVDEAEAVRFECQVEPKTDPSLRVEWYRNGKPLPSGHRY-RNIFDMGFVSLDILYVYGEDS 3880
            :....|.|.:....:|.|  :..|..|:.|..||:|:    :| |:..:.|...|.|.....||.
Human   530 LKDCAVIEGQDFVLQCSV--RGTPVPRITWLLNGQPI----QYARSTCEAGVAELHIQDALPEDH 588

  Fly  3881 GEYVCRAINNYGEDRTRATVSCKKLPTILLQNQVPRGMKRSDALTQMEATIKKYTSEVHLTEDDL 3945
            |.|.|.|.|..|:      |||....|:    ...:..::|:.|..:.                 
Human   589 GTYTCLAENALGQ------VSCSAWVTV----HEKKSSRKSEYLLPVA----------------- 626

  Fly  3946 FDPDRKQPPRFVTQIKE-------QLTLTEMAVTKFECQLAPVGDPNMKVEWFFNGKPLLHKNRF 4003
              |.:...|.|:..:.:       |:|:|        .|::  |:|..:|.|..||      |..
Human   627 --PSKPTAPIFLQGLSDLKVMDGSQVTMT--------VQVS--GNPPPEVIWLHNG------NEI 673

  Fly  4004 QPIYDFGYV------AMNFGWVYPEDSGEYVCRATNLYGKDETRAIIKVSGKPGIVYDSQLPAHM 4062
            |...||.:.      ::....|:|||:|.|.|.|.|..|:..|:|::.|.               
Human   674 QESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ--------------- 723

  Fly  4063 QSIDRIREMEASWQVVPDEVDPDAKPRTKPVFVSKLEPQTVEEGDPARFCVRVTGHPRPRVMWLI 4127
                                  :....|:|.|:||....|...|........:.|.|.|.|.||.
Human   724 ----------------------EPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLR 766

  Fly  4128 NGHTVVH--GSRYKLTNDGMFHLDVPKTRQYDTGKVEVIARNSVGE-------SIATTELKVVAR 4183
            :|..:..  |....|.|:.:|.|.:.|.:.:..|:.|::.:|.|||       .:..:..:.:.|
Human   767 DGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPR 831

  Fly  4184 ---------------------SDDYRNVLKNSPRPWYDYELAAYQKERQENELEKVFDERKQVLS 4227
                                 ||.|     .|.||.:......:.:|....::..|...|    .
Human   832 GREPASCEDLCGGGVGADGGGSDRY-----GSLRPGWPARGQGWLEEEDGEDVRGVLKRR----V 887

  Fly  4228 EQSSHTLKGVEHLKPKQYKPPTPDWQ----QNVKAKK-SEDYYNKLQTLETEQLLKETNLRRDTH 4287
            |...||.:.:...:.:|.     |::    :.|..|. |||   .|:.:..||:....||:|...
Human   888 ETRQHTEEAIRQQEVEQL-----DFRDLLGKKVSTKTLSED---DLKEIPAEQMDFRANLQRQVK 944

  Fly  4288 QYAIPGE--KVVSSSQAKGMAQSYEENLQEK-TSTTEV-QAAPPKGIAQPSESSVHGREVHMNKQ 4348
            ...:..|  ||.|..|.     .:...|.:| ||.|.| :..||...|.|...||.|     .|:
Human   945 PKTVSEEERKVHSPQQV-----DFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLG-----GKK 999

  Fly  4349 QQVQKEIQGDLEITRKITATETTE---VEHKGTIQERVVQGPVKPAKAPVFTKKIQPCRVFENEQ 4410
            :         |......::.||..   ||....:......||:||.......:.::|..      
Human  1000 K---------LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMG------ 1049

  Fly  4411 AKFEVEFEGEPNPTVKWYRESFPIQNS-PDLQIHTFSGKSILIIRQVFVEDSAVFSCVAENRGGT 4474
                   ..:|..|:|      |:.|: ||..:.:.|.:.   :::....|   .:|...:.|.|
Human  1050 -------NAKPAETLK------PMGNAKPDENLKSASKEE---LKKDVKND---VNCKRGHAGTT 1095

  Fly  4475 AKCSANLVVEERRRAGKGGIQPPSFVTTIQSTTVATGQLARFDAKVTGTRPLDVYWLKNGMKIQP 4539
            .        .|:|...:|  ..|:|...:|...||.|:......:|:...|..:.|..|| |...
Human  1096 D--------NEKRSESQG--TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNG-KTLK 1149

  Fly  4540 SIKFKML-EEDSVHTLLIIEPFAEDSGRYECVAVNAAGEARC----------------------- 4580
            :.||.:| :|.|:.::.|.:...||.|.|:|||.|.||:|.|                       
Human  1150 TTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSR 1214

  Fly  4581 ------------DGDCIVQSPSKPEKPTTPGSEKAPHIVEQLKSQTVEEGSKVIFRCRVDGKPTP 4633
                        :.|..|:  .||...|.|.:...|.|::..:.|.|..|..|....:|.|....
Human  1215 RPKSSLPPVLGTESDATVK--KKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPI 1277

  Fly  4634 TARWMRGENFVKPSRYFQMSRQGEYYQLVISEAFPEDEGTYKCVAENKLGSIQTSAQLKVRPIEN 4698
            |..||:....::.|.:.::.......:|.|..|..|..|.|..:.||||||.|  ||:.:..::.
Human  1278 TCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQ--AQVNLTVVDK 1340

  Fly  4699 LDAPPTITALKDVSVTEGMPAQFKTTVTGKVKATSVQWFREGQLIPETPDFQMIFDGNSAVLLIG 4763
            .|.|.......|:                :..:.::.|:...            :||.||     
Human  1341 PDPPAGTPCASDI----------------RSSSLTLSWYGSS------------YDGGSA----- 1372

  Fly  4764 TTYEEDSGIFTVRVTSSTGQVESSAKLTVKKRRISAFQLRTIDSAEDESSSSGREDSAPESPHAF 4828
                         |.|.:.::..||..|.|            :.|...|:|...:|..|:..:.|
Human  1373 -------------VQSYSIEIWDSANKTWK------------ELATCRSTSFNVQDLLPDHEYKF 1412

  Fly  4829 Q-------PGQQPGQQFGQFLGVNGQGQHQGRSR-------QKKPKV--RSKSLQPATKVIPWRK 4877
            :       ...:|.|:  ..|...|:...:.:..       :|:|:|  |:.::....||..:..
Human  1413 RVRAINVYGTSEPSQE--SELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYD 1475

  Fly  4878 SSRPTRGRSLDKGVFLPGFK---PEPVKSWTEETINLKATPIEKKKPA------------PKL-- 4925
            ..     ..|..|.|...|:   .:..|.|..:.  .||...::|:..            |||  
Human  1476 IE-----ERLGSGKFGQVFRLVEKKTRKVWAGKF--FKAYSAKEKENIRQEISIMNCLHHPKLVQ 1533

  Fly  4926 ------EAAKVVLKSIKTERDQGIMSLGATLEQIIAGK---TEKEAIPWITMREKLKAVESVQQQ 4981
                  |.|.:|:.       ..|:|.|...|:||...   ||:|.|.:  ||:..:.||.:.:|
Human  1534 CVDAFEEKANIVMV-------LEIVSGGELFERIIDEDFELTERECIKY--MRQISEGVEYIHKQ 1589

  Fly  4982 LNKFDLDEVYLQP-------------------LEGQIETEGQL------PQQAQVEQVQRTKEIQ 5021
                .:..:.|:|                   |..::|..|.|      |:....| |...:.|.
Human  1590 ----GIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPE-VINYEPIG 1649

  Fly  5022 RLKSMESVEIM--------------------------------EMTDQIDKLITQQQNAKDLIP- 5053
            ....|.|:.::                                |..|:|      ..:|||.|. 
Human  1650 YATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEI------SDDAKDFISN 1708

  Fly  5054 --WKEMRQQLKSVQ--------RVTKQIDKFKIEEVELRHLQAQQAITEEYQTGTAEETV----- 5103
              .|:|:.:|...|        :.||.::..|:.:..::...|::   :..:||.|...:     
Human  1709 LLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR---KWQKTGNAVRAIGRLSS 1770

  Fly  5104 -VMID-----ESSKGSISKVLRRDEQLQYEDQSNIYKQKFITTEDVNIMHVSEREKLEAQRLIRE 5162
             .||.     :||.||.:..|..::....||.|..:                    |||      
Human  1771 MAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAF--------------------LEA------ 1809

  Fly  5163 QQAVNWRQQQQRPQLQPLTS--VEDTVISQTSERQKLVQQQSFIEEAQRQQFVQVEDSQMMSLEE 5225
                   ..:::|.::|..|  :.|..:.:.|    ..:....||.....:.|..:|.|  |:.|
Human  1810 -------VAEEKPHVKPYFSKTIRDLEVVEGS----AARFDCKIEGYPDPEVVWFKDDQ--SIRE 1861

  Fly  5226 YEHQKI 5231
            ..|.:|
Human  1862 SRHFQI 1867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352 33/92 (36%)
Ig 3429..3490 CDD:143165 23/61 (38%)
I-set 3539..3630 CDD:254352 28/90 (31%)
Ig 3556..3625 CDD:143165 21/68 (31%)
I-set 3676..3767 CDD:254352 29/96 (30%)
IGc2 3690..3758 CDD:197706 20/68 (29%)
I-set 3811..3900 CDD:254352 25/89 (28%)
Ig 3828..3899 CDD:143165 21/71 (30%)
I-set 3954..4046 CDD:254352 28/104 (27%)
Ig 3963..4042 CDD:299845 25/84 (30%)
I-set 4092..4180 CDD:254352 25/96 (26%)
Ig 4102..4172 CDD:299845 21/78 (27%)
I-set 4394..4483 CDD:254352 13/89 (15%)
Ig 4411..4480 CDD:143165 12/69 (17%)
I-set 4497..4581 CDD:254352 30/119 (25%)
Ig 4519..4580 CDD:143165 23/61 (38%)
I-set 4604..4693 CDD:254352 27/88 (31%)
Ig 4621..4691 CDD:299845 21/69 (30%)
I-set 4702..4792 CDD:254352 11/89 (12%)
Ig 4702..4791 CDD:299845 11/88 (13%)
COG4372 4996..>5260 CDD:226809 54/298 (18%)
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
MYLKXP_024309300.1 I-set 43..133 CDD:254352 33/92 (36%)
I-set 171..260 CDD:254352 28/90 (31%)
23ISL 261..422 CDD:318761 14/160 (9%)
I-set 424..514 CDD:254352 29/121 (24%)
I-set 524..610 CDD:254352 28/97 (29%)
I-set 633..722 CDD:254352 28/104 (27%)
I-set 731..819 CDD:254352 25/87 (29%)
I-set 1108..1197 CDD:254352 30/89 (34%)
Ig8_hMLCK_like 1248..1345 CDD:143239 28/98 (29%)
FN3 1341..1433 CDD:238020 23/151 (15%)
STKc_MLCK1 1471..1729 CDD:271093 53/284 (19%)
I-set 1819..1909 CDD:254352 13/55 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10906
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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