DRSC/TRiP Functional Genomics Resources

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Protein Alignment sls and MYBPC3

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_000247.2 Gene:MYBPC3 / 4607 HGNCID:7551 Length:1274 Species:Homo sapiens


Alignment Length:1304 Identity:336/1304 - (25%)
Similarity:517/1304 - (39%) Gaps:277/1304 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly 16967 FSKKPKAQYVDENTNVILECRLVAVPEPD-----IVWTFNGEDIDEEEIKNVRIVTESDMHMYCS 17026
            |||||::..|...:..:.|.      |.:     :.|...|.||...  ....:.||...|    
Human    12 FSKKPRSVEVAAGSPAVFEA------ETERAGVKVRWQRGGSDISAS--NKYGLATEGTRH---- 64

  Fly 17027 VVHISKVKKSQEGTYEVIATNREGEARLPITLKVRTTDKEAPQILEPLRNMVIREGESVVLSTQI 17091
            .:.:.:|..:.:|:|.|||    |.:::...|||...:|..| :|.|.                 
Human    65 TLTVREVGPADQGSYAVIA----GSSKVKFDLKVIEAEKAEP-MLAPA----------------- 107

  Fly 17092 VGNPPPKVTWYKDGKPVKNAKSDKDLHTLTLITPQKSEKGEYTVKAVNPLGSVETTANLTIEEPA 17156
               |.|.......|:....|                :|.||   .|.:|.||    ::..:..|.
Human   108 ---PAPAEATGAPGEAPAPA----------------AELGE---SAPSPKGS----SSAALNGPT 146

  Fly 17157 GGNAEPP--LFVERFEEQNVPQKGEIRLPAKVSGNPV---PEVQWLFNNTPLFPSERIQQ----- 17211
            .|..:.|  |||.|.::..|...|.|...|:|:|..:   |.|:| |....:..|.::.|     
Human   147 PGAPDDPIGLFVMRPQDGEVTVGGSITFSARVAGASLLKPPVVKW-FKGKWVDLSSKVGQHLQLH 210

  Fly 17212 -VYDGEN----IELIIKDANPETDSGDYKCIAS-------NPIGKTSH----------------- 17247
             .||..:    .||.|.||.| ..:|.|:|..|       :....|.|                 
Human   211 DSYDRASKVYLFELHITDAQP-AFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRT 274

  Fly 17248 ----GARVIVEVDEVT----FTKKLKKTITIEEVQSLTLECETSHVVTTKWFFNGKELSGMDHRV 17304
                |.|.|.:..|.|    |:..|||..:....:...||......|   |....:.......|:
Human   275 SLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDV---WEILRQAPPSEYERI 336

  Fly 17305 VVEDGKTHKLVIRNTNLRDSGTYTCKVKKQETQSTVEVLQRKPDFIKVLED-YEVTEKDTAILDV 17368
            ..:.|.|.   :|....|..|     :::.|.:||.        |.|.||. |:|::.....|.|
Human   337 AFQYGVTD---LRGMLKRLKG-----MRRDEKKSTA--------FQKKLEPAYQVSKGHKIRLTV 385

  Fly 17369 ELTTEATEVTWYKDGEKITPENKNVEFIKDGKARRLVIRDVTIHDEGQYTCKIEGQECSCELVVI 17433
            ||.....||.|.|:|::|........|...|..|.|.|...::.|:..|.|.:.|::||.||.|.
Human   386 ELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVK 450

  Fly 17434 ELPPEIVEPLNDVAVTKGENAVFEVELSKGDALVKWFKNGKEIVFNE--RIQLAIDGKKQSLRIV 17496
            |.|..|..||.|..|..|:...||.|:|:..|.|||.|:|.|:...|  :.:...||::..|.|.
Human   451 EPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIIN 515

  Fly 17497 KAKPEDVGEYSVQVGEQTSKAKLTVEEPLVDFVIRLPDITLATKTTDAEFTVQLSQPDVEVTWCK 17561
            :|..||.|.|::......:.|:|.|:|..::....:.|:.:..| ..|.|..::|..:|...|.|
Human   516 EAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAK-DQAVFKCEVSDENVRGVWLK 579

  Fly 17562 KGKPIKPNQKHEVFVEGTVRRLVIHDASDEDAGEISCVAENVTS--STKLCVEELKL-------P 17617
            .||.:.|:.:.:|...|.|.:|.|.|.:..|..:.|.|.|....  |.||...|:|:       |
Human   580 NGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEP 644

  Fly 17618 PVITSD----KDQTIKVKENDDVTFTVKYTGVPTPEACWTTRKVVIPKSK---RTIPTIDEQSA- 17674
            |.|..|    ...||.|...:.:...|..:|.|.|...|  :|.:...:|   |..|...|.:. 
Human   645 PKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIW--QKAITQGNKAPARPAPDAPEDTGD 707

  Fly 17675 --------KL-------------------TIKKVVDDDEGEYTVKLVNPVGEAEASLHLVIMRKP 17712
                    ||                   |::....:|||.|||.:.|||||.:.:|.:.::..|
Human   708 SDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVP 772

  Fly 17713 TAPGTPQPLEIMHDSITLYWKAPEDDGKSEIIEYILEYQDVKEEKWTEIR--KIKDTTYTISKLK 17775
            .||..|:...:..||.|:.|:.|..||...|:.||||.:..|..:|..:.  .|::.::...::.
Human   773 DAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMI 837

  Fly 17776 IDTEYVFRSIAVNEVGPSPPSPLSPPIRLVPKVETKAPSVQEPLQDVVSELDKEVTLSCVF---- 17836
            ....|..|..|||.:|.|.|||.|.|.     :....||  ||....|.:: .:.|:|..:    
Human   838 EGVVYEMRVYAVNAIGMSRPSPASQPF-----MPIGPPS--EPTHLAVEDV-SDTTVSLKWRPPE 894

  Fly 17837 ----GGI--------PEPKVTWKKNGQ-VFESRSIRYEN---------RVAKY----------TI 17869
                ||:        ||....|....| :.|..||..::         ||..:          |.
Human   895 RVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTT 959

  Fly 17870 EKTTIETEATYTCVATNEKGSAETSCRLKLQQKPVLEVEDKYLTQKL--RTGSILTIPATVRGYP 17932
            |..|::                      ::.|:|.|:: .::|.|.:  :.|..:.:....:|.|
Human   960 EPVTVQ----------------------EILQRPRLQL-PRHLRQTIQKKVGEPVNLLIPFQGKP 1001

  Fly 17933 QPTVTWHKETIEQKTTKSVTIETTETTSTYTVKKVTREQSGKYKVTATNESGTTYVECTVQVIDK 17997
            :|.|||.||. :....:.|:|..:.|.:...::...|..||.|:||...|:........:||:||
Human  1002 RPQVTWTKEG-QPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDK 1065

  Fly 17998 PSRPQSLEIKDIKKDSIVLEWTPPVDDGGLDIEKYTLEKCDVQNNVWMKVSDFNKDIKSY----- 18057
            ||.||.|.:.|....::.|||.||.|.|..::..||::|.|.:...|..|      ::.|     
Human  1066 PSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTV------LEHYRRTHC 1124

  Fly 18058 AVQKLSMNAQYMFRVVAANPIGESE--PTESDPVTITKKFEKPSPPRGPTTVSGMNDTSFNLAWE 18120
            .|.:|.:...|.|||.:.|.:|.|:  .|..:||.|         ||...|....|..:.:.:..
Human  1125 VVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFI---------PRPGITYEPPNYKALDFSEA 1180

  Fly 18121 PSET 18124
            ||.|
Human  1181 PSFT 1184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352 23/97 (24%)
IGc2 16978..17050 CDD:197706 15/76 (20%)
I-set 17068..17152 CDD:254352 14/83 (17%)
Ig_2 17078..17152 CDD:290606 11/73 (15%)
IG_like 17170..17253 CDD:214653 28/123 (23%)
Ig 17180..17250 CDD:143165 25/110 (23%)
I-set 17260..17342 CDD:254352 17/81 (21%)
IGc2 17274..17331 CDD:197706 10/56 (18%)
I-set 17347..17432 CDD:254352 29/85 (34%)
IGc2 17367..17423 CDD:197706 17/55 (31%)
I-set 17437..17521 CDD:254352 29/85 (34%)
Ig <17468..17521 CDD:299845 17/54 (31%)
I-set 17528..17611 CDD:254352 24/84 (29%)
Ig 17553..17602 CDD:143165 15/48 (31%)
I-set 17618..17708 CDD:254352 31/124 (25%)
Ig 17635..17708 CDD:299845 25/103 (24%)
FN3 17712..17791 CDD:238020 24/80 (30%)
I-set 17813..17898 CDD:254352 21/120 (18%)
Ig 17830..17894 CDD:143165 16/99 (16%)
Ig 17922..17994 CDD:299845 18/71 (25%)
FN3 17998..18090 CDD:238020 31/98 (32%)
FN3 18098..18189 CDD:238020 7/27 (26%)
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
MYBPC3NP_000247.2 I-set 12..94 CDD:254352 23/97 (24%)
Ig 15..89 CDD:299845 19/89 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 107..153 13/88 (15%)
IG 161..256 CDD:214652 24/96 (25%)
ig 161..245 CDD:278476 24/85 (28%)
I-set 365..449 CDD:254352 29/83 (35%)
IGc2 384..442 CDD:197706 18/57 (32%)
I-set 456..541 CDD:254352 29/84 (35%)
IGc2 468..529 CDD:197706 22/60 (37%)
Ig 563..629 CDD:299845 19/65 (29%)
I-set 654..768 CDD:254352 28/115 (24%)
Ig_C5_MyBP-C 655..768 CDD:143302 28/114 (25%)
FN3 772..862 CDD:238020 29/89 (33%)
FN3 870..963 CDD:238020 20/95 (21%)
IG_like 981..1062 CDD:214653 20/81 (25%)
Ig_Titin_like 990..1062 CDD:143225 18/72 (25%)
FN3 1066..1154 CDD:238020 29/93 (31%)
I-set 1181..1270 CDD:254352 3/4 (75%)
IGc2 1200..1257 CDD:197706
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.918296 Normalized mean entropy S8067
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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