DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and MUC6

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_005952.2 Gene:MUC6 / 4588 HGNCID:7517 Length:2439 Species:Homo sapiens


Alignment Length:1450 Identity:282/1450 - (19%)
Similarity:412/1450 - (28%) Gaps:438/1450 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  7887 PTSAIE---DTVQQKLLSQEELIIAEVLPS-----------ETVGRDVTDVRPPGET-------- 7929
            |.|.||   :..|.:....||.:....:|.           .|.|...|.|.|...|        
Human  1170 PGSNIEGCYNCSQDEYFDHEEGVCVPCMPPTTPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLS 1234

  Fly  7930 ------------ISPRLTPNMSLCITECQPEDSIGEMQQAAKERMETPSMSVTESKAVGGQELEV 7982
                        .||..||.:...:|..:|..|.||..:        |:.:||.....|......
Human  1235 STGPSPSSNHTPASPTQTPLLPATLTSSKPTASSGEPPR--------PTTAVTPQATSGLPPTAT 1291

  Fly  7983 LENVDHMPLITQPTKGLADYTIKAEEVPVQVQEIITFDSLERETVAKTQTAKSNALELFELSEGL 8047
            |.:....|.:||.|                     |..:....:.|.|.||:|.......|....
Human  1292 LRSTATKPTVTQAT---------------------TRATASTASPATTSTAQSTTRTTMTLPTPA 1335

  Fly  8048 VSSTADSHSPIAEDLPIFEKDVKEATIDMQMQHHVTTSETVSNENAVKDLKAVDTPKMAEGTL-- 8110
            .|.|:          |...|               :|::.:....|.:......||....|..  
Human  1336 TSGTS----------PTLPK---------------STNQELPGTTATQTTGPRPTPASTTGPTTP 1375

  Fly  8111 --GQSSALTIGETQQMNLVETTVELIEPNVEST---KPAKGALTEAYG--TAESNEETLLESLGL 8168
              ||.:..|..||.|   ..||.|...|....|   .|..|:...:.|  ||.|...|       
Human  1376 QPGQPTRPTATETTQ---TRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHAT------- 1430

  Fly  8169 VPDDNRKIEQGKVNISEGEYVAKVQTTTVTDTEGEF---VSVAP---KLVNPKFDFVEQSALQIK 8227
                                     ||..|.:..|.   ..|.|   .||.|             
Human  1431 -------------------------TTYPTPSHPETTLPTHVPPFSTSLVTP------------- 1457

  Fly  8228 QDTTVEKEEILSSNIELAP---QLATSNMF----------PAELKVTSIYEVQPGLTSSDIITEQ 8279
                       |::..:.|   |:|||...          |..||.|......|.:|.:...|.|
Human  1458 -----------STHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATGSTHTAPPITPTTSGTSQ 1511

  Fly  8280 TKSVSANQVFETMSIGVTSKPDMLESTSHIDAFQHPEF-KTGDTILDENQQPLEV-TNVQITESS 8342
            ..|          |......|..|.  ||..:..|||. .|..|.:..|...... |.|..|.|:
Human  1512 AHS----------SFSTNKTPTSLH--SHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAHTNSA 1564

  Fly  8343 TDIIDVLPNQKLTKAETVTDGFKYAEGLVVLPMESTIDKTEDTKPTAVNADISMHQQFGTDVREQ 8407
            |   ...|....|.....|....::.   ..||.:|..||..|.||      ..|.|  |.:...
Human  1565 T---SSRPPPPFTTHSPPTGSSPFSS---TGPMTATSFKTTTTYPT------PSHPQ--TTLPTH 1615

  Fly  8408 EPLESTLTRTEDLKPQTQT----TESQFGLLQSLETSSCVTLEGESVL-SVKERHPEQSAAI--- 8464
            .|..||...|    |.|.|    |.:|.....|:.:....|:...:.| :....|...:..:   
Human  1616 VPPFSTSLVT----PSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTTS 1676

  Fly  8465 GTSSALQVANITRP-----QHMESLDRLDEQKVPYYQANVNIGEITLPNVEKIDSFDVLSDLNTP 8524
            |||.||...|..:.     .|..|....:....    :..||    .||.         :...||
Human  1677 GTSQALSSLNTAKTSTSLHSHTSSTHHAEATST----STTNI----TPNP---------TSTGTP 1724

  Fly  8525 DYNKSSKGRVQLIESTTSLKTTTAVVSE-STEELKDLNITQPVHIKPKPYESDQKISISEQTNVL 8588
            ....::.|..|...|.::.||:|::.|. |:....::..|....|.|....:..:..::..|:..
Human  1725 PMTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSAT 1789

  Fly  8589 EH-----------------VSSLNPV-LPALETIQSSIKSLHEINVRETDILEKEESLKDVDHIS 8635
            ..                 :||..|| ..:.:|..:.....|......|.:.....||     ::
Human  1790 SSRLPTPFTTHSPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSL-----VT 1849

  Fly  8636 GRLAKIILDCTTGIAQVRQEETLEHEEDLKAPLIPLEKAIPASSELHRLPLTEYVQEQQGTSDMT 8700
            .....:|:...|.:|      |......:....||....|.|:...|..|  .......|||.  
Human  1850 PSTHTVIIPTHTQMA------TSASIHSMPTGTIPPPTTIKATGSTHTAP--PMTPTTSGTSQ-- 1904

  Fly  8701 DFKVSNKCASPNIDHLYETKSSEMIVYDSSIN---SVDSEFPAGIVPQK----SLVPFRHTM--- 8755
                     ||:  .....|:|..:.|.:|..   .|.......|.|:.    :..|..||.   
Human  1905 ---------SPS--SFSTAKTSTSLPYHTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSAS 1958

  Fly  8756 -------VTENVAFNASENFEILSADQQIATNVQDSLSQSIIAEDQIAFETEQ---NLGLETTPT 8810
                   .|.:.....|..|.  |.....||:.|.:.:....:..|....|..   :..|.|..|
Human  1959 SSRLPTPFTTHSPPTGSSPFS--STGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSLVTPST 2021

  Fly  8811 HKPKLLKDDQ-----NLHAK---LVDEATVYEAMGQEQKVDKYNIQQAEITHDLPQVYAT--DLQ 8865
            |...:....|     ::|:.   .|...|..:|.|.              ||..|.:..|  ...
Human  2022 HTVIITTHTQMATSASIHSTPTGTVPPPTTLKATGS--------------THTAPPMTVTTSGTS 2072

  Fly  8866 QTFEAEKEITTREQSYVAAT----------------TDIIPSRLGLAMTTKTHPVEGIDVLLSS- 8913
            || .:.....|...|:::::                |..:|.     :::.|.||...:.|.|| 
Human  2073 QT-HSSFSTATASSSFISSSSWLPQNSSSRPPSSPITTQLPH-----LSSATTPVSTTNQLSSSF 2131

  Fly  8914 PPKPSLAQT--NYEETQHEVRVRETQAIEESEELTDGRLLPV------SAVESIDSTFKVTSDSQ 8970
            .|.||...|  :|..:.|......:.::..|......   ||      |...|..||...|:...
Human  2132 SPSPSAPSTVSSYVPSSHSSPQTSSPSVGTSSSFVSA---PVHSTTLSSGSHSSLSTHPTTASVS 2193

  Fly  8971 QPPVFDKE--------------------------LSIPTVSPLEARAKPSLNLLQGTTTFDVIPL 9009
            ..|:|...                          :|..||||     .||.:|...|..|...|.
Human  2194 ASPLFPSSPAASTTIRATLPHTISSPFTLSALLPISTVTVSP-----TPSSHLASSTIAFPSTPR 2253

  Fly  9010 ESSVLLKDTHVAVQKAQQEYVAQVESNKVHVQMDNLVMHKEDIFENAEIENFCKPITEGTQLETV 9074
            .::    .||.|...:.|...::..|....|.....|                 .:|.|    ..
Human  2254 TTA----STHTAPAFSSQSTTSRSTSLTTRVPTSGFV-----------------SLTSG----VT 2293

  Fly  9075 VIEVVPIDNVGGIHLAPQPSTLLATLTSTDIVNQSHVIDTQVPLEMESEAQAPLDNIAQARIKSA 9139
            .|...|:.|:...|..|..|.....|||:                :.:....|    |.|.:.|.
Human  2294 GIPTSPVTNLTTRHPGPTLSPTTRFLTSS----------------LTAHGSTP----ASAPVSSL 2338

  Fly  9140 EDHVHTNVSEVNVYEQTKAI 9159
            .....|:....:|.||.:.|
Human  2339 GTPTPTSPGVCSVREQQEEI 2358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
MUC6NP_005952.2 VWD 40..192 CDD:214566
C8 228..297 CDD:285899
TIL 302..357 CDD:280072
VWC_out 359..>403 CDD:214565
VWD 386..549 CDD:214566
C8 588..660 CDD:285899
TIL 664..721 CDD:280072
TIL 782..827 CDD:280072
VWC 829..886 CDD:302663
VWD 868..1017 CDD:278521
C8 1057..1127 CDD:285899
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1455 64/341 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1471..1626 46/184 (25%)
1, truncated 1561..1738 46/211 (22%)
Approximate repeats 1607..1953 74/394 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1642..1834 36/208 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1983 25/131 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2033..2077 11/58 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2090..2196 22/113 (19%)
PHA03255 2188..>2343 CDD:165513 36/204 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2233..2278 14/53 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2323..2348 5/28 (18%)
CT 2351..2434 CDD:214482 3/7 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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