DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and MUC5AC

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_001291288.1 Gene:MUC5AC / 4586 HGNCID:7515 Length:5654 Species:Homo sapiens


Alignment Length:1993 Identity:372/1993 - (18%)
Similarity:564/1993 - (28%) Gaps:493/1993 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  7696 TLAHETSAELPQSETLEQIEESLSTYETLPIQNLSKDTLQTVAVSVTTELSTP------SPTASR 7754
            |....|||..|:..:    ..:.||.........|..|..|.:.:.|:.:|.|      |||.|.
Human  2736 TTTSTTSAPTPRRTS----APTTSTISASTTSTTSATTTSTTSATTTSTISAPTTSTTLSPTTST 2796

  Fly  7755 VQEEI-------------LPQKVLAINEEVLPLDEFGLRKESPRPKENKLTENIEVRLKHALNVS 7806
            ....|             .||...............| ...||.|               ..:.:
Human  2797 TSTTITSTTSAPISSTTSTPQTSTTSAPTTSTTSGPG-TTSSPVP---------------TTSTT 2845

  Fly  7807 HAKTAESSKELPSKIPKSVKAQRKMKESRSLVVEAPNAEEAIEDLKPLKAVSQEVQSDILFSHEI 7871
            .|.|. |:...|:....||........:.:.....|....:     |:...|.........:...
Human  2846 SAPTT-STTSAPTTRTTSVPTSSTTSTATTSTTSGPGTTPS-----PVPTTSTTSAPTTRTTSAP 2904

  Fly  7872 TEEQHQALETIEKLKPTSAIEDTVQQKLLSQEELIIAEVLPSETVGRDVTDVRPPGETISP-RLT 7935
            |.....|..|.....|||:.........:|         :|:.:    .|.|  ||.|.|| ..|
Human  2905 TTSTTSAPTTSTTSAPTSSTTSATTTSTIS---------VPTTS----TTSV--PGTTPSPVPTT 2954

  Fly  7936 PNMSLCITECQPEDSIGEMQQAAKERMETPSMSVTESKAVGGQELEVLENVDHMPLITQPTKGLA 8000
            ..:|:..|......:..............|:.|.|.:.............:. .|..:.|:....
Human  2955 STISVPTTSTTSASTTSTTSGPGTTPSPVPTTSTTSAPTTSTTSAPTTSTIS-APTTSTPSAPTT 3018

  Fly  8001 DYTIKAEEVPVQVQEIITFDSLERETVAKTQTAKSNALELFELSEGLVSSTADSHSPIAEDLPIF 8065
            ..|:..           |..:....|.:.|.|..|:.....:.|....|:|:.:..|.....|: 
Human  3019 STTLAP-----------TTSTTSAPTTSTTSTPTSSTTSSPQTSTTSASTTSITSGPGTTPSPV- 3071

  Fly  8066 EKDVKEATIDMQMQHHVTTSETVSNENAVKDLKAVDTPKMAEGTLGQSSALTIGETQQMNLVETT 8130
                            .|||.|          .|..|...:..|....||.|...|.        
Human  3072 ----------------PTTSTT----------SAPTTSTTSAATTSTISAPTTSTTS-------- 3102

  Fly  8131 VELIEPNVESTKPAKGALTEAYGTAESNEETLLESLGLVPDDNRKIEQGKVNISEGEYVAKVQTT 8195
                .|...:|..:..:.|...||..|.                              :....||
Human  3103 ----APTTSTTSASTASKTSGLGTTPSP------------------------------IPTTSTT 3133

  Fly  8196 TVTDTEGEFVSVAPKLVNPKFDFVEQSALQIKQDTTVEKEEILSSNIELAPQLATSNMFPAELKV 8260
            :...|.....|.|.|...|              .||.            :|...||.:|......
Human  3134 SPPTTSTTSASTASKTSGP--------------GTTP------------SPVPTTSTIFAPRTST 3172

  Fly  8261 TSIYEVQ----PGLTSSDIITEQTKSVSANQVFETMSIGVTSKPDMLESTSHIDA---------F 8312
            ||.....    ||.|.|.:.|..|.|||.... ..:||..|:....:....|:..         |
Human  3173 TSASTTSTTPGPGTTPSPVPTTSTASVSKTST-SHVSISKTTHSQPVTRDCHLRCTWTKWFDIDF 3236

  Fly  8313 QHPEFKTGDTILDEN---------QQPLEVTNVQITESSTDIIDVLPNQKLTKAETVTDGFKYAE 8368
            ..|....||.....|         ::|.|:|.:|....|...:.:....::.:...       .|
Human  3237 PSPGPHGGDKETYNNIIRSGEKICRRPEEITRLQCRAESHPEVSIEHLGQVVQCSR-------EE 3294

  Fly  8369 GLV-------------------VL----PMESTIDKTEDTKPTAVNADISMHQQFGTDVREQEPL 8410
            |||                   ||    |....:..|..|.|:..:.            |...|.
Human  3295 GLVCRNQDQQGPFKMCLNYEVRVLCCETPKGCPVTSTPVTAPSTPSG------------RATSPT 3347

  Fly  8411 EST-----------LTRTEDLKPQTQTTESQFGLLQSLETSSCVTLEGESVLSVKERHPEQSAAI 8464
            :||           :|.:....|||.||.:......|..|:|..:....|..|..:.....:...
Human  3348 QSTSSWQKSRTTTLVTTSTTSTPQTSTTSAPTTSTTSAPTTSTTSAPTTSTTSTPQTSISSAPTS 3412

  Fly  8465 GTSSALQVANIT-RPQHMESLDRLDEQKVPYYQANVNIGEITLPNVEKIDSFDVLSDLNTPDYNK 8528
            .|:||...:.|: |...:.|.........|       ....|........|....|..:||..:|
Human  3413 STTSAPTSSTISARTTSIISAPTTSTTSSP-------TTSTTSATTTSTTSAPTSSTTSTPQTSK 3470

  Fly  8529 SSKGRVQLIESTTSLK-------TTTAVVSESTEELKDLNITQPVHIKPKPYESDQKISISEQTN 8586
            :|..    ..||||..       |||:..|.|......:::::..|.:|...:...:.:.::..:
Human  3471 TSAA----TSSTTSGSGTTPSPVTTTSTASVSKTSTSHVSVSKTTHSQPVTRDCHPRCTWTKWFD 3531

  Fly  8587 VLEHVSSLNPVLPALETIQSSIKSLHEINVRETDILEKEESLKDVDHISGRLAKIILDCTTGIAQ 8651
            |  ...|..|.....||..:.|:|..:|..|..:|...:...|....:|......::.|:     
Human  3532 V--DFPSPGPHGGDKETYNNIIRSGEKICRRPEEITRLQCRAKSHPEVSIEHLGQVVQCS----- 3589

  Fly  8652 VRQEETLEHEEDLKAPL---IPLEKAIPASSELHRLPLTEYVQEQQGTSDMTDFKVSNKCASPNI 8713
             |:|..:...:|.:.|.   :..|..:.........|:|       .||.......|.:..||..
Human  3590 -REEGLVCRNQDQQGPFKMCLNYEVRVLCCETPKGCPVT-------STSVTAPSTPSGRATSPTQ 3646

  Fly  8714 DHLYETKSSEMIVYDSSINS----------VDSEFPAGIVPQKSLVPFRHTMVTENVAFNASENF 8768
            ......||....:..|||.|          ..|..||.| |..:..|...|......:..::...
Human  3647 STSSWQKSRTTTLVTSSITSTTQTSTTSAPTTSTTPASI-PSTTSAPTTSTTSAPTTSTTSAPTT 3710

  Fly  8769 EILSADQQIATNVQDSLSQSIIAEDQIAFETEQNLGLETTPTHKPKLLKDDQNLHAKLVDEATVY 8833
            ...|..|...::...|.:.|......|:..|...:...||.|..              ...|:..
Human  3711 STTSTPQTTTSSAPTSSTTSAPTTSTISAPTTSTISAPTTSTTS--------------APTASTT 3761

  Fly  8834 EAMGQEQKVDKYNIQQAEITH----------DLPQVYATDLQQTFEAEKEITTREQSYVAATTDI 8888
            .|..........|...|..|.          ..|....|...||.......|:...:...:||..
Human  3762 SAPTSTSSAPTTNTTSAPTTSTTSAPITSTISAPTTSTTSTPQTSTISSPTTSTTSTPQTSTTSS 3826

  Fly  8889 IPSRLGLAMTTKTHPVEGIDVLLSSPPKPSLAQTNYEETQHEVRVRETQAIEESEELTDGRLLPV 8953
            ..:....|.||.|          :|.|..|...|.............|.|...|         .:
Human  3827 PTTSTTSAPTTST----------TSAPTTSTTSTPQTSISSAPTSSTTSAPTAS---------TI 3872

  Fly  8954 SAVESIDSTFKVTSDSQQPPVFDKELSIPTVSPLEARAKPSLNLLQGTTTFDVIPLESSVLLKDT 9018
            ||..:..::|..||.:..|.  ....|.|..|...| |..|.....|||. ..:|..|:..:..|
Human  3873 SAPTTSTTSFHTTSTTSPPT--SSTSSTPQTSKTSA-ATSSTTSGSGTTP-SPVPTTSTASVSKT 3933

  Fly  9019 ---HVAVQKAQQEYVAQVESNKVHVQMDNLVMHKEDIFENAEIENFCKPITEGTQLETVVIEVVP 9080
               ||:|.|.            .|.|......|....:......:|..|...|...||       
Human  3934 STSHVSVSKT------------THSQPVTRDCHPRCTWTKWFDVDFPSPGPHGGDKET------- 3979

  Fly  9081 IDNV--GGIHLAPQPSTLLATLTSTDIVNQSHVIDTQVPLEMESEAQAPLDNIAQARIKSAEDHV 9143
            .:|:  .|..:..:|..:                 |::....||..:..::::.|....|.|:.:
Human  3980 YNNIIRSGEKICRRPEEI-----------------TRLQCRAESHPEVSIEHLGQVVQCSREEGL 4027

  Fly  9144 HTNVSEVNVYEQTKAIQDQNKHGLFVKVSKNSDTSKAYLTTIQSTFLKEDILPKPNILQDTAQAA 9208
                          ..::|::.|.| |:..|.:.......|           ||...:..|...|
Human  4028 --------------VCRNQDQQGPF-KMCLNYEVRVLCCET-----------PKGCPVTSTPVTA 4066

  Fly  9209 ADELQSLVTEEVVSVSSIQETYELKIPLQKTANL----TQQTPQNSVNVCQQLAY--EETPDIAF 9267
            ........|....|.||.|::        :|..|    |..|||.|.......:.  ..||....
Human  4067 PSTPSGRATSPTQSTSSWQKS--------RTTTLVTTSTTSTPQTSTTSAPTTSTIPASTPSTTS 4123

  Fly  9268 EPHALTRA----TTSSVPTFLK---PAENATVNIYENIEGHGDFKPGTVNLTS--NSNLNSELVV 9323
            .|...|.:    :|:|.||...   |..:.|:             ..|.:.||  .::.||....
Human  4124 APTTSTTSAPTTSTTSAPTHRTTSGPTTSTTL-------------APTTSTTSAPTTSTNSAPTT 4175

  Fly  9324 SVVQEVT----SVPSLGSLA------TVEPQELKAMPVTKSSTNLAYSEEGGIPYVQITVEEAKL 9378
            |.:...|    |.|:..:::      |..||..|....|.|:|:.:.:....:|....|  .|..
Human  4176 STISASTTSTISAPTTSTISSPTSSTTSTPQTSKTSAATSSTTSGSGTTPSPVPTTSTT--SAST 4238

  Fly  9379 VNTRADVEENITS--VTTEQPNMCIAASIQLPAIEEKKLENALQTPQFASESILKTSPQISRNAH 9441
            .:|.:....:.||  .||..|         :|:           |...::.:...||...:|...
Human  4239 TSTTSAPTTSTTSGPGTTPSP---------VPS-----------TSTTSAATTSTTSAPTTRTTS 4283

  Fly  9442 FETRTHEEEYSTTTESLVTTQALRDDIDSTQKNVMQDVQMYKHFATKSLDKTVKVETDTNQA--T 9504
            ..|.:......||...:.||........||...         ...|.|...|    |.|..|  |
Human  4284 APTSSMTSGPGTTPSPVPTTSTTSAPTTSTTSG---------PGTTPSPVPT----TSTTSAPIT 4335

  Fly  9505 DTTHIKQKTPTHKLASSTTQI-TESPEIIKTIETISEDG-SPS 9545
            .||.....||:....:|||.. |.|.....|..|.|..| :||
Human  4336 STTSGPGSTPSPVPTTSTTSAPTTSTTSASTASTTSGPGTTPS 4378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
MUC5ACNP_001291288.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..49
VWD 74..216 CDD:214566
C8 266..334 CDD:370094
TIL 338..394 CDD:366828
VWD 423..587 CDD:214566
C8 624..694 CDD:214843
TIL 704..761 CDD:366828
TIL 802..863 CDD:366828
VWD 892..1051 CDD:214566
C8 1088..1162 CDD:214843
PHA03247 <1335..1576 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1336..1377
9 X Cys-rich subdomain repeats 1383..4731 372/1993 (19%)
Mucin2_WxxW 1389..1475 CDD:372569
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1483..1575
Mucin2_WxxW 1584..1670 CDD:372569
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1688..1733
Mucin2_WxxW 1749..1840 CDD:372569
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1849..1948
Mucin2_WxxW 1957..2043 CDD:372569
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2059..2110
Mucin2_WxxW 2122..2213 CDD:372569
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2224..3214 111/626 (18%)
107 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 2257..3200 106/611 (17%)
Mucin2_WxxW 3228..3319 CDD:372569 15/97 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3329..3515 42/208 (20%)
17 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 3363..3498 33/145 (23%)
Mucin2_WxxW 3526..3617 CDD:372569 18/98 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3628..3951 74/372 (20%)
34 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 3661..3931 60/307 (20%)
Mucin2_WxxW 3959..4050 CDD:372569 19/129 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4060..4625 83/375 (22%)
58 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 4093..4595 74/334 (22%)
Mucin2_WxxW 4633..4724 CDD:372569
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4830..4849
VWD 4911..5079 CDD:214566
C8 5147..5205 CDD:370094
VWC 5383..5447 CDD:327433
CT 5534..5616 CDD:214482
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5622..5654
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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