DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and Hml

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster


Alignment Length:2425 Identity:415/2425 - (17%)
Similarity:747/2425 - (30%) Gaps:920/2425 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly 12959 SSEKEDIPSFTTTVVEDEIVNPVLPEKIKTVDDVRVPKD-----KKKKIDNQKKIKISEFEPTPT 13018
            |..|.|:|: ||.:....:....||..:.|.:..:..|.     .|.:..:.|.:::::.|..|.
  Fly  1714 SGVKCDVPA-TTGLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPR 1777

  Fly 13019 SE------DSTIEEYTPKL-----SEHDEDLQTDEYSVDVKDSLPKSKKKSTKKQKKESLP--GP 13070
            .:      .:.:::|..|:     ..|:...|.||   :|..||            :|.|.  |.
  Fly  1778 YDRMENVYGTCLKQYMTKVECRVKDTHEAPEQMDE---NVVCSL------------EEGLRCIGK 1827

  Fly 13071 ISLYTIR--------IEETTPEPITEKIYEDGKEVVRVINKRRIKKKAGPKE------------- 13114
            ...|.:|        :|...|:| |||     .::....:...::.|..|.:             
  Fly  1828 CHDYELRAFCQCDEELEPELPKP-TEK-----PQLGLACDAAVVEYKEFPGDCHKFLHCQPKGVE 1886

  Fly 13115 ----YLIEVIETYEDNNPE---ADVVIRTIETTPSIDSKPQEDHKIQVVQEKKP---------KT 13163
                |:.:....|...||.   .|.:....|..|:...||:.:.:.:.:::..|         :.
  Fly  1887 GGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFEPIKQCPPGKIKSECANQC 1951

  Fly 13164 ESLDNYIQKLIDQE-IPQVDHKEFKATVLETSPESKKAKKIKKHHKKTTEVIDGIPITVIEVTIQ 13227
            |:..:|...::.:. :.||........|.|..|:..|..|                         
  Fly  1952 ENTCHYYGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGK------------------------- 1991

  Fly 13228 ETETDDEDFKPDEVTLKEIDHENAEEAPKVLKSK--VSEEKPKSKKEKSLEFKIAE--------- 13281
                    |..||.|.     .:|:|.|.:.|::  |...||...     ||::.:         
  Fly  1992 --------FWRDEDTC-----VHADECPCMDKAEHYVQPHKPVLG-----EFEVCQCIDNAFTCV 2038

  Fly 13282 EDKPKPVLEDISEDVQVVQII------------------------EEDGTPKQVEIKKKKVSRKH 13322
            .:||:||.:|..:|:.:|.::                        .....|..:.....:::.:|
  Fly  2039 PNKPEPVPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEH 2103

  Fly 13323 GPKEQVFEITETKAIDEPLSEVTVVEITDEQPQEEVLPA-QEKKPIKKQKKLKPE---------- 13376
            |||                    :..:|.|||:....|: .::....:....|||          
  Fly  2104 GPK--------------------MARLTKEQPRGSWSPSINDQMQYLELNFAKPEPFYGVVMAGS 2148

  Fly 13377 -DVNTYVV--KVL------------EELTEPTQFE-------------TIPEDAD---------- 13403
             :.:.||.  |:|            :|..:|..|.             .||.:|.          
  Fly  2149 PEFDNYVTLFKILHSHDGIAYHYLVDETEKPQMFNGPLDSRAPVQTLFKIPIEASSLRIYPLKWH 2213

  Fly 13404 ---------------DKPQPV-----IEDISE------NVQVVQII-EEDGTPKQVEIKKKKV-- 13439
                           ::|:||     |..|:|      :::.:.:: .::|...|.:::...:  
  Fly  2214 GSIAMRVELLICGDKEEPKPVPTVSTILPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSLWQ 2278

  Fly 13440 SPKHGPKEQVFEITETRPSDEPLAEVTIVELTEEGLNKDIVIPQEKKTVKKPKKLKPEDIQSYV- 13503
            .|..|.|.|:.|:.:.   ..|||...:.....|.:..|.              |:|.:|..:| 
  Fly  2279 QPNLGKKLQLLELLKL---STPLAWRPLANSQNEFIEFDF--------------LEPRNISGFVT 2326

  Fly 13504 ----------IRVLEEFNEPQW-----------------PASTEK------PIIEDIAESIEIVP 13535
                      .:|:....:|.|                 .|.||:      ||   :.:.|:|||
  Fly  2327 KGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNPI---LTQYIKIVP 2388

  Fly 13536 VTEEDGITKEVE-----------VKKKKVSRKQGTKNQVFEIIETKTSDEPLAEVTILELSGDKS 13589
            ...|..|...:|           .::..|...:.||..:.:.:.|.:|.........|...|:..
  Fly  2389 AYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNICDGVSTSSSTTGCQCQDQLFWDGNTC 2453

  Fly 13590 QEVTILPKEKKPIKKTIKLKPEDVESYVVNVLEEFCEPQSFESPEPTEGEAHETKT------KTK 13648
            .:..:.|               .:|:||           |:......|..|.|...      |..
  Fly  2454 VQHNLCP---------------CIENYV-----------SYPIGSKFENSACEDCVCVLGGHKNC 2492

  Fly 13649 KPKKPIVKAPENVILIEEMAPETVIENIVNEIGEEVKQVKTTKKLKKKEG-PKEYLIEIKETYEE 13712
            ||||               .|..        :|.:::.|.|:....|.|. ||         ::.
  Fly  2493 KPKK---------------CPPC--------LGGKLRPVITSDCFCKCEPCPK---------HQR 2525

  Fly 13713 NKPEGDIEITTTELVPE-----GSPDASDDQPVIVVQKIKKKKPVKDDLDKYIQQLIEQEITKTP 13772
            ..|      ::.:.:||     |..|.:||:..    .......|:.|:.:   :..|.|:...|
  Fly  2526 LCP------SSGDCIPEILWCNGVQDCADDEDA----SCSDSFTVEPDVSR---EKNETEVITCP 2577

  Fly 13773 LEEYEP------TEMDSKKKPKKKVKSHNKKTIEVIDGLPVTIHEFNVEDIVSEPEDMETPKTLL 13831
            :....|      ||..|:|  ..|:.:.:|:...|.||..:|..:|    |.|:.:.:..|...|
  Fly  2578 VPVCPPQMKIRITEKKSRK--MSKMFTFSKQVSIVDDGTTITKTKF----ISSKEQILAMPNREL 2636

  Fly 13832 DEIKEIPQLPDDSSKYLVNISDEFGEADKPIKQPTQDQPIKKEKP-LKKKKDVEYPVSLEAFDHT 13895
            |.     ||.:.        .|||.....|.||..:::.:...:| ..:|.|||..:|.......
  Fly  2637 DF-----QLEEQ--------CDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDC 2688

  Fly 13896 VK--VVSEP--------------TLEGTV------------------------KEVTVKKRKVSR 13920
            ::  .|..|              |.:|||                        ::.:.:.|||..
  Fly  2689 LRYSCVLRPNKDDVCEISGKSFTTFDGTVFKYGPCSHILARDIHSSSWSISVHQQCSDETRKVCH 2753

  Fly 13921 RKGSKDHIFEITETTSEDRPTA-----------EVTVVELSSDEVLDSEEKPKHERKIVKKPKQ- 13973
            :      :..|.:|.:.:....           |.||.:|.:..:..:.       .:|.:|.: 
  Fly  2754 K------VITIQDTEAGNELILLPHLKLKFNGYEFTVQQLINSPICKAS-------FVVSQPGKT 2805

  Fly 13974 -----------LKKDDVEEYIINIIEEFIQPIPVGLVEDEVEKVQKEETKKPKKSPITYIATEQE 14027
                       ::.||:....:.|..:||:.:      |.:........|..|:||...|....|
  Fly  2806 LLAVSTKYGFWVQLDDIGIVKVGISSKFIRTV------DGLCGYYNGNQKDDKRSPDGQIIPNTE 2864

  Fly 14028 D-NDNNYDALVKEDLDQPIERALEKPSSPLEYTISVEEDSVGEEQKQPKPKK------------- 14078
            . .|:.||..:.:|....::...|..:..|:....:...:.....|....|:             
  Fly  2865 KFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYCLEAACNC 2929

  Fly 14079 -------------------ISKPKSIK--------------------------------QPSVDK 14092
                               :.|..|:.                                :||.| 
  Fly  2930 MMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEINCPSPLVHTDCYKRRCEPSCD- 2993

  Fly 14093 SPDYLVNVISEESII--DEPIPEDYVVTEAAEEKPSEEPTFKVEELETEAV--EKEVTDDDKGET 14153
                  ||..::..:  |...|..|.......:.|:..|..:.::....::  .|.:|.|.|..:
  Fly  2994 ------NVHGDDCPVLPDACFPGCYCPEGTVRKGPNCVPISECKDCVCNSLGASKYMTYDRKSFS 3052

  Fly 14154 TKQSVTKRKIKKLVGPKEEIIEIVETKTGDTPEYEVIVTTEEVQEKSKEAPEE------------ 14206
            ...:.|....:.:|.|.      |.|       ::|.|:.::.::..:..|.|            
  Fly  3053 FNGNCTYLLSRDVVLPG------VHT-------FQVYVSMDDCKKLGQPTPVEGGSCAKSLHILN 3104

  Fly 14207 -----------KKAKTVR------KAKKIPKDD----LQDYIQKLIEQDIPKTELE--------- 14241
                       :|.|:::      :.||||..|    |:..:.|.:...:|::.:|         
  Fly  3105 GDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESHVELTASFEDLI 3169

  Fly 14242 ------------KYEKI----------DLDEPVKMKRKPIKKVKQ----------------SEEQ 14268
                        |.|.:          || :|...|:|....|.|                ||:.
  Fly  3170 FSLGVPSIKYGSKMEGLCGDCNGNAGNDL-QPNPAKKKAGVDVIQSWQADEPKLGLVEECLSEDV 3233

  Fly 14269 PKEE-TEEPIEDKP----------------VEKISEYSEVDSD-------EPKLTVAVKEFIPE- 14308
            |||. ...|.|..|                |:.|:..|....|       :..:.||:..:..| 
  Fly  3234 PKEHCIPLPPEKDPCLQFYNAELFGKCPLAVDPIAYVSACQQDICKPGNTQQGVCVALAAYAKEC 3298

  Fly 14309 ----------KPEEKPFEI---VVLE--------ETVESKREPDEEGKVREKVVKTKK-----IK 14347
                      :|:..|:|.   :|.|        :|:::..|.|......|.||.|.|     :.
  Fly  3299 NQHGICTNWRRPQLCPYECPSDMVYEPCGCAKNCDTIKALSEFDAVSLKNEAVVHTVKTDEMCLS 3363

  Fly 14348 QNR--------GSVEVVHDIVEEIDTDTNESVITVTTT-------VPTETPDQD-----QPSVKQ 14392
            ..|        |.|           .|..:.|..:..|       :|.|...:|     |...|.
  Fly  3364 SERFEGCFCPPGKV-----------MDGGQCVPEIACTKCDDGLHLPDEKWKKDKCTECQCDSKG 3417

  Fly 14393 KRTKKIKKDEVEDFVKRVIEEEAPQPEGSVDLVVIEDFVPK-----------------------P 14434
            |.|...||.:||:    .|..|..:||   .:|.:::..|:                       |
  Fly  3418 KTTCVEKKCQVEE----NICAEGYRPE---TIVSVDECCPRYRCVPETKDPSKLCLAPLVPICGP 3475

  Fly 14435 SSEKRKKKPIKDKHTSVEEETPHEDEVLLIESVPEDSPLSDDLITVVDSVPIEEEPENKVNQIED 14499
            ...|::||.:            :.....:.|.:|:|   ..::|.:.:.:|.|     .:..:|:
  Fly  3476 GQFKKEKKDV------------NGCSQYICECIPKD---QCEIIELRELLPGE-----IIVNVEE 3520

  Fly 14500 TKKPEKKKKPKPSAKILEENVPEDTVEKPLEALHTDSDLEKPDVQEFSISIKEEEQKHTHPEKKK 14564
            ...|.:|.:.||      |..|:..|... |..:....:::|.:                    .
  Fly  3521 GCCPTQKIECKP------ETCPKAPVNCQ-ERFYEVKTIKEPGM--------------------C 3558

  Fly 14565 SSKISSEQPKQPSTEQYEISVTEHDLKPEEEKPFTVQVIQSETNVEETKDDTGKVHKQVTTKRML 14629
            .||.|...||.....|||:         :|...||..|....|:.:|       |.||.|..   
  Fly  3559 CSKHSCVPPKDLCIVQYEL---------DEATKFTKTVGDKWTHAKE-------VCKQETCS--- 3604

  Fly 14630 RRPAGEGEI--EIIEVVRDDQPEAEI----------------TIVEYEPEPVNQDEKPKEPKKKT 14676
            ..|.|..::  .:.:.:.|..|....                .|.|.:...||...|..:.....
  Fly  3605 YGPDGNAQVVSTLEQCLTDCAPGFSYQNLDKTKCCGKCVQTSCIFEQKLYEVNALWKSADNCTTY 3669

  Fly 14677 RKVKKD-------------DIHDYIQKLIELETPKTELEKYE-----KIEFEPIVKDKPLDSPID 14723
            ..:|||             |:...:..|:           |:     :.:.||:|:||....|:.
  Fly  3670 SCLKKDGQFLVTTSREVCPDVGSCLSHLL-----------YQDGCCKRCKSEPLVEDKSSCLPVS 3723

  Fly 14724 VLDESPKEVQKKDKKSRSTKVPNEETPVQ---------EQYAKVNVVEEEAPEQPEIPVQILEVK 14779
            :.:...||:.|...:...|.|  ...|:|         ...:|.|.: .:..|:......|....
  Fly  3724 LAESRTKEILKFPVQGHGTCV--NADPIQGFTDCEGACSSGSKYNTL-TDMHEKFCTCCSIKSYH 3785

  Fly 14780 PVEVDVKEVITEDGKPVQEK 14799
            |:.|   ::|.:||....:|
  Fly  3786 PISV---KMICDDGHTFTQK 3802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064 53/274 (19%)
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072
TIL 1245..1298 CDD:280072
VWD 1327..1498 CDD:214566
C8 1535..1609 CDD:214843
Mucin2_WxxW 1751..1837 CDD:290069 18/100 (18%)
TIL 1938..2005 CDD:280072 15/104 (14%)
FA58C 2089..2223 CDD:238014 23/153 (15%)
FA58C 2104..2225 CDD:214572 21/140 (15%)
FA58C <2299..2404 CDD:214572 22/121 (18%)
FA58C <2299..2403 CDD:238014 22/120 (18%)
VWD 2703..2858 CDD:295339 25/173 (14%)
C8 2893..2970 CDD:285899 5/76 (7%)
TIL 2974..3030 CDD:280072 10/62 (16%)
VWD 3035..3198 CDD:295339 26/175 (15%)
C8 3257..3313 CDD:285899 8/55 (15%)
VWC 3397..3451 CDD:302663 16/60 (27%)
GHB_like <3755..3813 CDD:304424 10/52 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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