|
Fly 1290 APQFTRGLHNIETIEGTNVHLECRLQPVGDPSMRIEWFVNGKPVKTGHRFRPAYEFDYVALDLLG 1354
||.|.|.|.|.....|::|.| |:...|.|...:.||.:|:.:.| |..|.. .|.|..
Rat 44 APVFLRPLKNAAVCAGSDVRL--RVVVSGTPEPSLSWFRDGQLLPT-----PVPEPS--CLWLRN 99
Fly 1355 CYAIDSGVYTCQARNQLGEA-----VTSCSVRII---AKNDLILETQNES-----GLQKIQYLED 1406
|.|.|:|||:|.|:|:.|:| :|...||:. .|.....||..:. |.|:::..:|
Rat 100 CGAQDAGVYSCSAQNERGKASCEAVLTVLEVRVFRSCRKQSYDSETAEDDISDVPGTQRLELRDD 164
Fly 1407 STRHRRSEFVDEVVNIRPRFLTHPKSLTNTREGGHAHFECKIEPVTDPNLKVEWFKNGRPITVGH 1471
......:...|.:|. ....|.|.|:|.|.|. :|.|:.:|:
Rat 165 RAFSTPTGGSDTLVG--TSLDTPPTSVTGTSEE-----------------QVSWWGSGQ------ 204
Fly 1472 RFRPIHDFGYVALDIVHLIAEDSGVYTCRAVNLIGSDETQVELQCRSGEQIVTVTQNEAGLEQIH 1536
||.:.|||
Rat 205 ----------------------------------------------------TVLEQEAG----- 212
Fly 1537 YLEDRSRYTRREEIDESTKQAPVFTTSLKNVEIKENQRAHFECRLIPVSDPSMRVEWYHNNLPLK 1601
....|| .:..|.:||.......:::.::...||. ...|:..| |
Rat 213 ----SGGGTR--PLPGSPRQAQTTGAGPRHLGVEPLVRAS-RANLVGAS-------W-------- 255
Fly 1602 SGSRFTETNNFGFVALDIMSTLPEDAGTYTCRAYNAVGEAITSAVAVVHTKKSIYLESQHETALP 1666
|| ||:.:.....|.:...........:| .::|
Rat 256 -GS--------------------EDSLSVASDLYGSAFSLYRGRALSIH------------VSIP 287
Fly 1667 RLQHLEDGSKRQRISVQDEFVSQA----PVFTMPVRDVRVAENQAVHFEARLIPVGDPKLTVEWL 1727
..|.:|:...:|.:..|.| |....|.: :.|:|...|::....|
Rat 288 -----PSGLRREEPDLQPQPASDALRPRPALPPPSK-------------SALLPPPSPRVGKRAL 334
Fly 1728 RNG----------------QPIEASNRTTTMHDFGYVALNMKYVNPEDSGTYTCRAVNELGQAVT 1776
... :|....:.|||....| ...|...|..:||...|....|.:|..
Rat 335 PGSSAQPPATPTSPHRCTQEPSLPEDITTTEEKRG---KKPKSSGPSLAGTVESRPQTPLSEASG 396
Fly 1777 SASLIVQSKTSIQLETQHEAAMHKIHQLEDHSRYQRREEEEYTVTTAPV-------FVTKLIGPS 1834
..|.:.:|...::..:: .:.|:...|: :||..|......||: ....|..|.
Rat 397 RLSALGRSPRLVRAGSR---ILDKLQFFEE----RRRSLERSDSPPAPLRPWVPLRKARSLEQPK 454
Fly 1835 NLVEGQSAHYECRIEPYPDPNLKVEWFHNGKPLSTGHRFRTTYDFGFAALDILTVYAEDSGEYTC 1899
: ||.:| :..|....|...: |..:....|..:....|:||..|.....:.:...
Rat 455 S--EGGAA--------WDTPGASQEELRS--PRGSVAERRRLFQQKAASLDERTRQRSATSDLEL 507
Fly 1900 RVTNNLGEAINSIVLNVTSRSSIIHETQHEEALTKIQHLEDTSRFQRKTDEEQFHAERPQFGRPL 1964
|....||....| |||..::. .||.....:| :....:...|.|.|.||.
Rat 508 RFAQELGRIRRS-----TSREELVR--SHESLRATLQ----------RAPSPREPGEPPLFSRPS 555
Fly 1965 RNAKVNEGAPVHLEATLIP-------VNDPTMKVEWYCNGRPIQTGHRFKTTYDFGFVALDILYA 2022
........:|. ||..| ..|.| |||...|...:|....| ...
Rat 556 IPKTSRAVSPA---ATQPPPPSGAGKSGDET--------GRPRSRGPVGRTEPGEG------PQQ 603
Fly 2023 HAEDTGTYMCKAKNAIGEA---VTTCAVNVTANKTLDLDTLDAQRLEKIRQLETYAPPPKPVVEE 2084
..:....:......||.|. |.....:...::| ....|::.|...|...:.|...|.||:
Rat 604 EIKRRDQFPLTRSRAIQECRSPVPPFTADPPESRT---KAPSARKREPPAQAVRFLPWATPGVED 665
Fly 2085 KGQKPIFLTPLSNLEHLKEGEHAHLECRVEPINDPNLKIEWFCNGKQLPTGHRYRTTHDFGYVAL 2149
. :.| ..||..:.|..|....|..|..|. .|
Rat 666 S------VLP-QTLEKNRAGPEAEKRLRRGPEEDG----PW------------------------ 695
Fly 2150 DILYVYGEDTGTYICKATNQLGEAVNTCNVRVLNRRSMILDTQHPDALEKIQKLESKVPNARTEV 2214
|.:..:.|...|: .||: .|.:.| |||. .::....
Rat 696 ----------GAWDRRGTRSQGK----------GRRA------RPTSPE----LESS-DDSYVSA 729
Fly 2215 GDAPISPPHFTAELRGSTEIYEGQTAHFEAQVAPVHD----------PNLRIEFYHNGKPLPSAS 2269
|:.|:..|.|...|:... |||..| |..::.:..:|..|.|..
Rat 730 GEEPLEAPVFEIPLQNMV-------------VAPGADVLLKCIITANPPPQVSWKKDGSVLHSEG 781
Fly 2270 RFHITFDFGYVSLDITHAVAEDAGEYSVRAVNALGQAVSSTNLRVIPRGT-------IISDTQH- 2326
|..|..:....:|.:..|.|.|||.|:..|.|.||||..:::|.|.|..: |.||.::
Rat 782 RLLIRAEGERHTLLLREAQAADAGSYTATATNELGQASCASSLAVRPGASTSPFSSPITSDEEYL 846
Fly 2327 ------PEGLEKIRKLESTAPHQRQEPETPGTRQR--PVFTQPLQNIDRINEHQTAHFEARLIPV 2383
||..|...:..:..|...|:.::..:..: |.|...|.: ..:.|.|......|: .
Rat 847 SPPEEFPEPGETWSRTPTMKPSPSQDRDSSDSSSKAPPTFKVSLMD-QSVREGQDVIMSIRV--Q 908
Fly 2384 GDPNLKVEWYRNEKIIE-DSSRITKQHDFGFVSLDISHIRKEDEGVYMCRAVNPLGEAVTTASMR 2447
|:|...|.|.||.:.:. |..|..::.:.|...|.|....:.|.|.|.|:|||..|.....|.:.
Rat 909 GEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLE 973
Fly 2448 VVSEASIQMDTQHPDSISRIHQLEKPLAPRPTEPERLFEKPIFTQLLTGPSELWEGTHAHFEARV 2512
| ..||:|.|. ..|||.........|..:|..|:.||::
Rat 974 V---------RAHPESRSL-----AVLAPLQDVDVGAGEMALFECLVAGPAD------------- 1011
Fly 2513 VPVGDPSLKFEWFINGVELQMG-SRLRTTHDFGFVTLDITAVVPEDAGVYMCRAYNAAGEAVSST 2576
::.:|...|..||.. .:.:...|.....|.:|:|..:|:|||.|:......|...|.
Rat 1012 -------VEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTVKDELTCSA 1069
Fly 2577 AMKVKTKSNIDGQPLIPESWEAIRLKEAAMNRVPEMFVDSTPQQAPVFTTHLQSYDKLHEGQHVL 2641
.:.|: |..||:||..|:..:.| ||:...
Rat 1070 RLTVR------------------------------------PSLAPLFTRLLEDVEVL-EGRAAR 1097
Fly 2642 LEAQVEPRADPNLRIEWFKNGISLTTGSRIRSTFDFGLVTLSINGLRADDSAIYTCKATNQVGEA 2706
|:.::.....|: :.|...|..:.....:|...|.||.:|.|..:.::|..:|...|||..|:|
Rat 1098 LDCKISGTPPPS--VTWTHFGHPVNESENLRLRQDGGLHSLHIARVGSEDEGLYEVSATNTHGQA 1160
Fly 2707 VSTSSLKIED-RHWLQAESLHPDSLPRIGELEAPKEGRPEAPE----PTYETPVFITHLNNIECK 2766
..::.|.:|: |......|...:.:|.| ||.|| .....|.|:..|.::|..
Rat 1161 HCSAQLYVEEPRTAASGPSSKLEKMPSI----------PEEPEHGDLERLSIPDFLRPLQDLEVG 1215
Fly 2767 ESDNVRFECNVEPARDPTMSIEWFYNGQPLQAA-----AKFKSIYDFGYCALDLTNSYAENSGVY 2826
.:.....||.|.....||:| ||:||..:|:: .:::.|:...:.|:. .:::|||
Rat 1216 LAKEAMLECQVTGLPYPTIS--WFHNGHRIQSSDDRRMTQYRDIHRLVFPAVG-----PQHAGVY 1273
Fly 2827 TCKATNSKGSATTSGTLKCTGGKTMFLDTQHPQGEAGLEAVQETEEELANRYTSKTTKPETQYPP 2891
.....|..|.|.....|..|. :....|.|...:.|| ..|..:.:..|
Rat 1274 KSVIANKLGKAACYAHLYVTD-----VVPGPPDGAPQVVAV-------TGRMVTLSWNP------ 1320
Fly 2892 PVWTKPLQAEFHLSEAQPIHLEANVEPKEDPNLFIEWYFNGKMLNHGSRFKMTSEFGFVTMDMIE 2956
|..|:..::|
Rat 1321 -----------------PRSLDMAIDP-------------------------------------- 1330
Fly 2957 VYARDQGIYTCKAYNKAGEAFTSTTIFCSSKENIIESTQHPKGA-----EGLEQIQDLEDSLRKD 3016
|...||.:......:.:|: ::...:.|:.| :||..|..:..|..|.
Rat 1331 ----DSLTYTVQHQVLGSDQWTA----------LVTGLREPEWAATGLKKGLHHIFRVLSSSGKS 1381
Fly 3017 GSKPEQPDLGI------PPRFTTEFV----NIADIGEGELA-------HFEANLIPVGDQSMVIE 3064
.|||..|...: ||......| :|..:.||:.| |.||.::
Rat 1382 SSKPSAPSEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEAQVV---------- 1436
Fly 3065 W-FYNGKVLEASHRVRT-IYAFG-----TVALEVLGTKIEDTGTYTCRATNKHGTAEISCNLECV 3122
| ...|.:||. || :|... ...|.:......|.|..||.|.|:|||...|..||.
Rat 1437 WRSCRGALLEP----RTGVYELSQPDDDQYCLRICRVSRRDLGPLTCSARNRHGTKACSITLEL- 1496
Fly 3123 DKPRGQKPRFTSHIQPLEGLKDGQSAHFECTLIPVNDPDLKVEWYHNGKLMRHSNRIKTVSDFGY 3187
.:.|||.|.::.:| :..|::|.|...:.....|| :.||.:..|:..||.:..|.:...
Rat 1497 ----AEAPRFESIMEDVE-VGPGETARFAVVVEGKPLPD--IMWYKDEVLLAESNHVSFVYEENE 1554
Fly 3188 VVLDISYLQDHDSGEYVCRAWNKYGEDFTRTTLNC-GGRGGVFYDSLQPDSLQRIRELECPQGQQ 3251
..|.:......|.|.|.|.|.|..||...:..|:. ..:..:..:.:..|...|.|.| ...
Rat 1555 CSLVVLSAGSQDGGVYTCTARNLAGEVSCKAELSVHSAQTAMEVEGVGEDEEHRGRRL----SDY 1615
Fly 3252 ADTSAPLVAEPPKFITQIVD-------VTKLVEGQ-----SAHFEARLTPITDPDLVVEWYFNGK 3304
.|....:......::.::|: ..|.:..| ||..||||......|.|:
Rat 1616 YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVL------- 1673
Fly 3305 KLPHGHRFRTFHDF-----GIVILDILYCYEENSGVYEARARNKYGEDVTRASLKCASKSSLILD 3364
.||:. |:||:..| |.|| :.|..|| ...:.:
Rat 1674 ---------YFHEAFERRRGLVIVTEL-CTEE---LLERMAR-----------------KPTVCE 1708
Fly 3365 SQLPRGMEGGLEKIANLEYSMVRTREETTEETKGKAPVFTVPLENIENLREGENAHFEARITPAD 3429
|:....|...||.|..|..|.|...:... |||...:.|..|.::...|
Rat 1709 SETRTYMRQVLEGIGYLHQSHVLHLDVKP-----------------ENLLVWDGAGGEEQVRICD 1756
Fly 3430 DPKLKVEWYWNGRPLKAGSRFRTFCDFG---FVILEI---SPV------YPEDSGEYSC-RAINE 3481
:.|.:.|..|. ..:|.|| ||..|| ||| :|.....:.| ..|:.
Rat 1757 --------FGNAQELTPGE--PQYCQFGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP 1811
Fly 3482 Y-GEAVTTATMKIQGKRSIIMES---QLPKGMEGTIDRIAELEGLGSRSTEFVPDDDTGKPPEFI 3542
: ||...|..|.|:.......|: .|.:...|.:.:: .|.|
Rat 1812 FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKV------------LVQD---------- 1854
Fly 3543 TSPFDMVIGENALAHFECRLQPINDPSMRVDWFHNGKALWAGSRIKTINDFGFVILEIAGCYQRD 3607
||:|..:.::...|| |....|:.:.|.:
Rat 1855 ------------------RLRPTAEETLEHPWF---KTEAKGAEVSTDH---------------- 1882
Fly 3608 SGLYTCKATNKHGEATVSCKLQVKGRQGIVMEP-----------QLPSNFRTGTESLQKLEETMH 3661
..|:..:...:..:.:..|.|.::....::..| |.||. |..|....||
Rat 1883 LKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVAMPRRQPPSG---GLSSSSDSEE--- 1941
Fly 3662 KREELVTEDEQPNP--PKFTEEIKDNLDVPEGGPIHFDCRVEPVGDP----TMRIEWFYNGHVMA 3720
|||......|.| |:|:.......|:| ...|.:|.| ...::|...|
Rat 1942 --EELEELPSVPRPLQPEFSGSRVSLTDIP--------TEDEALGTPEAGAATPMDWQEQG---- 1992
Fly 3721 TGSRVHQLNDFGFIALDVDYIYARDSGEYTCRATNKWGTATTSAKVTCKGKHNIVYESQLPEGMT 3785
||.:|...|.:...:...|:.: |:| .
Rat 1993 -------------------------------RAPSKDQEAPSPEALPSPGQES-------PDG-P 2018
Fly 3786 SEKLKELERGRIPEA--PKVVEEVFG----------------PPKFTTQITSVTVDEAE-AVRFE 3831
|.:..||.||...|: |:|.....| |....|::|...:.|.| |.|.:
Rat 2019 SPRRPELRRGSSAESALPRVGSREPGRSLHKAASVELPQRRSPSPGATRLTRGGLGEGEYAQRLQ 2083
Fly 3832 CQVEPKTDPSLRVEWYRNGKPLP-----SGHRYRNIFDMGFVSLDILYVYGEDSGEYVCRAINNY 3891
:||....|.| | ||.|...:..:|..:.|
Rat 2084 ---------ALRQRLLRGG---PEDGKVSGLRGPLLESLGGRARD-------------------- 2116
Fly 3892 GEDRTRATVSCKKLPTILLQNQVP---RGMKRSDALTQMEA-----------------------T 3930
.|.....|.:..| .:|.| ||:::|.:.:|.|| .
Rat 2117 --PRMARAASSEAAP----HHQPPPESRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARR 2175
Fly 3931 IKKYTSEVHLTEDDLFDPDRKQPPRFVTQIKEQLTLTE----MAVTKFECQLAPVGDPNMKVEWF 3991
:::..|...|:| .|||........:.::|: .|.|..:....|..
Rat 2176 LQESPSLSALSE--------TQPPSPALPSAPKPSITKSPEPSAATSRDSPQPPAP--------- 2223
Fly 3992 FNGKPLLHKNRFQPIYDFGYVAMNFGWVYPEDSGEYVCRATNLYGKDETRAIIKVSGKPGIVYDS 4056
||:.: ..||...|.| ||.. ..:|.:..
Rat 2224 ------------QPVPE----------KIPEPKPEPV-RAAK-------------PAQPPLAL-- 2250
Fly 4057 QLPAH--------MQSIDRIREMEASWQVVPDEVDPDA-------------------KPRTKPVF 4094
|:||. |||: ::.....|.||.|.|..|.| ..|..||.
Rat 2251 QMPAQSLTPYAQIMQSL-QLSSPTLSPQVPPSEPKPHAAVFARVASPPPGASEKRVPSARIPPVL 2314
Fly 4095 VSKLEPQTVEEGDPARFCVRVTGHPRPRVMWLINGHTVVHGSRYKLTNDGMFHLDVPKTRQYDTG 4159
..|:...||. ||| .:.:.||...|.::.:|.....::|
Rat 2315 AEKVRVPTVP--------------PRP--------GSSLSGSIENLESEAVFEAKFKRSR----- 2352
Fly 4160 KVEVIARNSVGESIATTELKVVARSDDYRNVLKNSPRPWYDYELAAYQKERQENELEKVFDERKQ 4224
||..:..|::::|| :..:........|:
Rat 2353 -----------ESPLSRGLRLLSRS-----------------------RSEERGPFRGAEDD--- 2380
Fly 4225 VLSEQSSHTLKGVEHLKPKQYKPP---TPDWQQNVKAKKSEDYYNKLQTLETEQLLKETNLRRDT 4286
|: |:|. || || |::.....|..
Rat 2381 -----------GI-------YRPSPAGTP--------------------LE---LVRRPERSRSV 2404
Fly 4287 HQYAIPGEKVVSSSQAKGMAQSYEENLQEKTSTTEVQAAPPKGIAQPS--------ESSVHGREV 4343
....:.|| .|:.:....:|.:|...| |.|...|: |||..|...
Rat 2405 QDLRVAGE--------PGLVRRLSLSLSQKLRRT------PPGQRHPAWESRSGDGESSEGGSSA 2455
Fly 4344 HMNKQQQVQKEIQGDLEITRKITATETTEVEHKGTIQERVVQGPVKPAKAPVFTKKIQPCRVFEN 4408
..:....|::.:...|| ..::.::..|:.:: .|.......|:|.:
Rat 2456 RGSPVLAVRRRLSSTLE-------RLSSRLQRSGSSED---SGGASGRSTPLFGR---------- 2500
Fly 4409 EQAKFEVEFEGEPNPTVKWYRESFPIQNSPDLQIHTFSGKSILIIRQVFVEDSAVFSCVAENRGG 4473
|:..|..|:| :|::.|..:. :|...|.
Rat 2501 -------------------------------LRRATSEGES---LRRLGVPHNQ----LASQTGA 2527
Fly 4474 TAKCSANLVVEERRRAGKGGIQPPSFVTTIQSTTVATGQLARFDAKVTGTRPLDVYWLKNGMKIQ 4538
|...:.:|..| .:|..|...|. :|.:.....|:|. .|:....|
Rat 2528 TTPSAESLGSE---ASGTSGSSAPG-----ESRSRHRWGLSRL--------------RKDKGLSQ 2570
Fly 4539 PSIKFKMLEEDSVHTLLIIEPFAEDSGRYECVAVNAAGEARCDGDCIVQSPSKPEKPTTPGSEKA 4603
|::. ..::||..|..: ||:.:.|
Rat 2571 PNLS-ASVQEDLGHQYV---------------------------------PSESDFP-------- 2593
Fly 4604 PHIVEQLKSQTVEEGSKVIFRCRVDGKPTPTARWMRGENFVK--PSRYFQMSRQGEYYQLVISEA 4666
|....:||.|.:.||......|.....|||...||:.:..:: ||......:.|... |.|..|
Rat 2594 PVFHIKLKDQVLLEGEAATLLCLPAACPTPRISWMKDKQSLRSEPSVVIVSCKDGRQL-LSIPRA 2657
Fly 4667 FPEDEGTYKCVAENKLGSIQTSAQLKVRPIENLDAPPTI-TALKDVSVTEGMPAQFKT----TVT 4726
.....|.|:|.|.|.||||.:|..:.|.......|||.: ....|.::....|...:. |:.
Rat 2658 SKRHAGLYECSATNVLGSITSSCTVAVARTPGKLAPPEVPQTYCDTALVLWKPGDSRAPCTYTLE 2722
Fly 4727 GKVKATSVQWFREGQLIPETPDFQMIFDGNSAVLLIGTTYEEDSGIFTVRVTSSTGQ---VESSA 4788
.:|...|| |......||:. ..|...|.:|.|.. |.|..::..|| ...|.
Rat 2723 RRVDGESV-WHPVSSGIPDC-------YYNVTQLPVGVTVR-----FRVACSNRAGQGPFSNPSE 2774
Fly 4789 KLTVKKRRISAFQLRTIDSAEDESSSSG-REDSAPESPHAFQPGQQPGQQFGQFLGVNGQGQHQG 4852
|:.::..:.|..| :..:..|...:|| .....|:||.:..|......|..|...::.......
Rat 2775 KVFIRGTQDSPAQ--SAAAPRDAPVTSGPTRAPPPDSPTSLVPTPPLAPQVSQASTLSPSTSSMS 2837
Fly 4853 RSRQKKPKVRSKSLQPATKVIPWRKSS-----------------RPTRGRSL--DKGVFLP---- 4894
:.|....:::....||| |.||.. .|:..:|. |.|...|
Rat 2838 -ANQALSSLKAVGPPPAT---PPRKHRGLLATQQAEPSPPSILVTPSEHKSFVPDTGTLTPTSSP 2898
Fly 4895 -GFKPEPVKSWTEETINLKATPIEKKKPAPK--LEAAKVVLKSIKTERDQGIMSL----GATLEQ 4952
|.||.|..|......:..:.|.:.:.|||: .|..||.::|:...:: ::|. ..||.|
Rat 2899 QGVKPAPSSSSLYMVTSFVSAPPDPQPPAPEPPPEPTKVTVRSLSPAKE--VVSSPTPESTTLRQ 2961
Fly 4953 IIAGKTEKEAIPWITMREKLKAVESVQQQLNKFDLDEVYLQPLEGQIETEGQLPQQAQVEQVQRT 5017
|..:| |:..:.||.:....|.:...:......::..:. ....||: .:..|..:|.||
Rat 2962 ---GPPQK---PYTFLEEKARGRFGVVRSCRENATGRTFVAKIV-PYAAEGK-RRVLQEYEVLRT 3018
Fly 5018 KEIQRLKSMESVEIMEMTDQIDKLITQQQNAKDLI 5052
...:||.|:....| |.:...||.:....::|:
Rat 3019 LHHERLMSLHEAYI---TPRYLVLIAESCGNRELL 3050
| 
