DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and Fras1

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:XP_038947596.1 Gene:Fras1 / 289486 RGDID:1306516 Length:4014 Species:Rattus norvegicus


Alignment Length:2354 Identity:436/2354 - (18%)
Similarity:799/2354 - (33%) Gaps:718/2354 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  8488 DEQKVPYYQANVNIGEITL--PNVEKIDSFDVLSDLNTPDYNKSSKGRVQ-LIESTTSLKTT-TA 8548
            |:...|....|   |.:||  .:::.:| |.:|:       .:...|||: |:....|..|. ..
  Rat  1097 DKVYTPSLHVN---GSLTLGIGSMKPLD-FSLLN-------IQHQDGRVEDLLFHIVSTPTNGQL 1150

  Fly  8549 VVSESTEEL----------KDLN--ITQPVHIKPKPYESDQKISISEQTNVLEHVSSLNPVLPAL 8601
            ::|.:.:|:          ||:|  ..:.||.|.|..:....:.||:|....|         |.|
  Rat  1151 LLSRNGKEVQLEKAGHFSWKDVNGKKVRFVHSKEKLRKGYFSLKISDQQFFSE---------PQL 1206

  Fly  8602 ETIQSSIKSLHEINVRETDILEKEESLKDVDHIS-GRLAKIILDCTTGIAQVRQEETLE------ 8659
            ..||:       .:.:...:|..|     |.||| |..|.|    ||.:..:|.::..:      
  Rat  1207 INIQA-------FSTQAPYVLRNE-----VLHISKGERAAI----TTQLLDIRDDDNPQDVVLNV 1255

  Fly  8660 -----HEEDLKAPLIPLEKAIPASS-------ELHRLPLTEYVQEQQGTSDMTDFKVSNKCASPN 8712
                 |.:.|:.|      ..||:|       ||.|..|.........|||:..|:.::..:..|
  Rat  1256 LDPPRHGQLLRTP------PAPAASVYQFHVDELSRGLLLYAHDGSDSTSDIIVFQANDGHSFQN 1314

  Fly  8713 IDHLYETKSSEMIVYDSSINSVDSEFPAGIVPQKSLVPFRHTMVTENVAFNASEN--FEILSADQ 8775
            |  |:..|:  :...|.::..|.:...  .||:..::...:.::........:::  ::|.....
  Rat  1315 I--LFRVKN--VPKNDRALRLVTNSMV--WVPEGGMLKITNRILRAQAPGVRADDIIYKITHDHP 1373

  Fly  8776 QIATNVQDSLSQSIIAEDQIAFETEQNL----GLETTPTHKPKLLKDDQNLHAKLVDEATV-YEA 8835
            |....|   |..::.| |..|...|:..    |..|||.         .....:.:|:..| |..
  Rat  1374 QFGEVV---LLMNLPA-DSPAGPAEEGHHLPDGRMTTPV---------STFSQQDIDDGIVWYRH 1425

  Fly  8836 MGQEQKVDKYNIQQAEITH--DLPQVYATD---LQQTFEAEK-------EITTRE--------QS 8880
            .|...:.|.::.|.:..|:  :.||.:..:   |.|..||.|       .:|.||        ||
  Rat  1426 SGATAQSDSFHFQVSTATNAQEHPQSHMFNIAILPQALEAPKLSLGTSLHMTAREDGLSVIHPQS 1490

  Fly  8881 YVAATTDIIPSRLGLAMTTKTHPVEGIDVLLSSPPKPSLAQTNYEETQHEVRVRETQAIEESEE- 8944
            ......:....::...:|...||.:|:......|..|....|..|..|.::..|...|....:| 
  Rat  1491 LSFGKAESPSGKIIYNITVPLHPNQGVIEHRGRPNSPIRYFTQEEINQGQIMYRPPAAPPHLQEF 1555

  Fly  8945 -----------------LTDGR-LLPVSAVESIDSTFKVTSDSQQPPVFDKELSIPTVSPLEARA 8991
                             ::||: ..|..|:     |..:....:|||.|..:..:..|||     
  Rat  1556 MAFSFAGLPESVRFYFTVSDGQHTSPEMAL-----TIHLLHSDRQPPAFQIKAPLLEVSP----- 1610

  Fly  8992 KPSLNLLQGTTTFDVIPLESSVLLKDTHVAVQKAQQEYVAQVESNKVHVQM------DNLVMHKE 9050
                    |..|    ||...::::|..|    ..:|...|::....|..:      .::.|...
  Rat  1611 --------GGRT----PLGLQLVVRDAEV----VPEELFFQLQKPPQHGMLMKYTAKSSVTMSAG 1659

  Fly  9051 DIFENAEIE----------------NFCKPITEGTQLET--VVIEVVPIDNVGGIHLAPQPSTLL 9097
            |.|...|:|                |....:|:|..:.|  |.:||.|.:| ....||| .|:|.
  Rat  1660 DTFTYDEVERNVLQYVHDGSPAWEDNMEISVTDGLTVTTSEVKVEVSPSEN-REPRLAP-GSSLS 1722

  Fly  9098 ATLTS--TDIVNQSHV--ID------------TQVPL-------------EMESEAQAPLDNIAQ 9133
            .|:.|  |.|:.:||:  :|            :.:||             |:..::...:::|..
  Rat  1723 MTVASQHTAIITRSHLAYVDDSSPDSEIWIQLSSLPLYGVLLKTSGPDMEELSGDSNFTMEDINS 1787

  Fly  9134 ARIK----------SAEDHVHTNVSEVN-------VYEQTKAIQDQNKHGL-FVKVSKNSDTSKA 9180
            ..|:          |..|..|.:||:::       |:..|....:...|.: |..:....:..:|
  Rat  1788 KNIRYSAVFETEGQSVTDGFHFSVSDMDNNRVDNQVFTITVTPAENPPHIIAFADLITVDEGGRA 1852

  Fly  9181 YLTTIQSTFLKED-------------ILPKPNILQDTAQA------------AADELQSLVTEEV 9220
            .| ::...|..||             .|||...:::|...            |:..:|.::...:
  Rat  1853 PL-SLHHFFATEDQDNLQGDAVIKLSALPKYGCIENTGTGDRFGPGANSELEASFPIQDVLENYI 1916

  Fly  9221 VSVSSIQETYELKIPLQKTANL-----TQQTPQNSVNVCQQLAYEETPDIAFEPHALTRATTSSV 9280
            ....|:.|:.|   |.....:.     :.::..:|:|:..:...:|.|.:...|..:..::..::
  Rat  1917 YYFQSVHESIE---PTHDVFSFYVSDGSGRSEIHSINITIERKNDEPPRMTLRPLGVRLSSGVAI 1978

  Fly  9281 ---------------------------------PTFLKPAENATV------NIYENI-EGHGDFK 9305
                                             ||...|.||.||      ..|::| .|...:.
  Rat  1979 SNSSLSLQDLDTPNNELIFVLMKKPDHGYLLLRPTASDPLENGTVLDQGSSFTYQDILAGLVGYL 2043

  Fly  9306 PGTV---------NLTSNSNLNS-ELVVSVVQEVTSVP----------SLGSLATVEPQELKAMP 9350
            ||.:         :||...:::: .:.:.:....:::|          |.||:|.:..|.|:|..
  Rat  2044 PGDIYMAVDEFRFSLTDGLHVDTGRMEIYIELPTSNIPHLAINRGLQLSAGSVARITEQHLRATD 2108

  Fly  9351 VTKSSTNLAY--SEEGGIPYVQIT----VEEAKLVN-----TRADVEENIT-------------- 9390
            ....:..|.|  .|:.|..::|:|    :|:..:..     |:|||.:...              
  Rat  2109 TDSEAGQLVYIVKEDPGAGHLQMTKADKLEQISVRGPIRSFTQADVSQGQIEYSHGPGEAGGSFA 2173

  Fly  9391 ---SVTTEQPNMCIAASIQLPAIEEKKLENALQTPQFASESILKTSPQISRNAHFETRTHEEEYS 9452
               .|...:.|.....|..:..:|:|            |..::.|:..:..:            .
  Rat  2174 FKFDVVNGEGNKLADQSFSINVLEDK------------SPPVIITNKGLVLD------------E 2214

  Fly  9453 TTTESLVTTQALRDDIDSTQKNVMQDVQM------YKHFATKSLDKTVKVETD-TNQATDTTHIK 9510
            .:.|.:.|.|.|..|.||....::..:..      .:|.|:..:..:...:.| |::.....|  
  Rat  2215 NSVEKITTAQLLATDQDSKPTELIYRITSQPQLGHLEHVASPGIQISSFTQADLTSRNVQYVH-- 2277

  Fly  9511 QKTPTHKLASSTT--------QITESPEIIKTIETISEDGSPSKKMIRTRLIKKVKGNKQEFTKI 9567
             .:.|.||:.:.:        ::|::..|  ||..: :|..|   :::.|.::..:|.::..|:.
  Rat  2278 -SSGTGKLSDAFSFVLSDGLHEVTQTFSI--TIHPV-DDSLP---LVQNRGMRVQEGVRKTITEF 2335

  Fly  9568 E--TVEEDDKQPETTVTVEELPYEEEKPEEIQELPEEVCVVETVTEDGKPKKKKIRTRVIKK-VK 9629
            |  .|:.|.:....|.|:.:.|                                 |...|:: .:
  Rat  2336 ELKAVDVDTEAESITFTIVQPP---------------------------------RHGTIERTAR 2367

  Fly  9630 GDKQEVTKIETVEE-------------DDKQPETTVTVEE--VPY--EEEKPEEIQ-ELPEEVRV 9676
            |.:.::|...|:|:             :..:...|.||.:  .|:  .||..|||. ..|::..|
  Rat  2368 GQRYQLTSSFTMEDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFIIEEGGEEIMTAAPQQFLV 2432

  Fly  9677 VETVTEDGKPKKKKIRTRV----IKKVKGDKQE-VTKIE--TVEEDDKQPETTVTVEEVP---YE 9731
            .....:||.|   :|.|.:    ::.:.|.... :||.|  ||:.|.:..:.|..|...|   |.
  Rat  2433 DILPVDDGTP---RIVTNLGLQWLEYMDGKATNLITKKELLTVDPDTEDSQLTYEVTTGPMHGYV 2494

  Fly  9732 EEKPEEIQELPEEVRVVETVTEDG-----------KPKKKKIRTRFIKKVKGDKQEVT------- 9778
            |.|       .:..||..|.|::.           :.|.:|:...|...||..|..|.       
  Rat  2495 ENK-------LQPGRVAATFTQEHVNLGLIRYVLYEEKIQKMMDSFQFLVKDSKPNVVSDNIFYI 2552

  Fly  9779 -------KIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTR 9836
                   |..:....:|....:|.|:....           ..:..:|...||.|.....   :|
  Rat  2553 HWSLISFKYTSYNVSEKAGSVSVMVQRTGN-----------LNQYAIVLCRTEQGTASSS---SR 2603

  Fly  9837 VIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEV-------------- 9887
            | ....|.:..|.....|:.|:::...:.|:  |..:::..|.|:....|:              
  Rat  2604 V-SSHPGQQDYVEYAGQVQFDEREDTKSCTI--VINDDDVFENIESFTVELSMPAYALLGEFTQA 2665

  Fly  9888 RVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQ 9952
            :|:...|||....:...:|..:.:..|......|        :|.:.:..|..:.|...|    .
  Rat  2666 KVIINDTEDEPTLEFDKKTYRVNESAGFLFAPIK--------RQGDPSSAVSAICYTVPK----S 2718

  Fly  9953 ELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEE 10017
            .:...:..:|: ..|.|.:.:.:.:||:   .|.....:..:.:..||.:           ||||
  Rat  2719 AMGSSLYALES-GSDFKSRGRSVESRVL---LGPGVTTSTCDVMVIDDSE-----------YEEE 2768

  Fly 10018 KPEEIQ--------------------ELPEEVRVVE------TVTED-GKPKKKKIRTRVIKKVK 10055
            :..||.                    ..|.:...|.      |::|| |..|...||...     
  Rat  2769 EEFEIALADASNNARIGRLAVAKVLISGPNDASTVSLGNTAFTISEDAGTVKVPVIRHGT----- 2828

  Fly 10056 GDKQEVTKIETAEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTR 10120
             |....|.:..|.........|..|:.|| ...|.|....:.|:...:..:.:...|..:.:.|.
  Rat  2829 -DLSTFTSVWCATRPSDPASATPGVDYVP-SSRKVEFGPGVTEQYCTLTILDDTQYPVIEGLETF 2891

  Fly 10121 VIKKVKGDKQEVTKIETVEEDDKQPETTV-----TVEEVPYEE--------EKPEEIQELP---- 10168
            |:........|:||          |...|     |.::||..:        ::.|.:..:|    
  Rat  2892 VVFLSSAQGAELTK----------PSQAVIAINDTFQDVPSMQFSKDLLLVKEKEGVLHIPIIRS 2946

  Fly 10169 ------EEVRVV-----ETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPE----- 10217
                  ..||..     ..|.||.:.::....:| |..:||:|.:...:...::...:||     
  Rat  2947 GDLSYESSVRCYTQSHSAQVMEDFEERRNADSSR-ITFLKGEKAKNCTVYIHDDSMFEPEEQFRV 3010

  Fly 10218 --------------------TTVTVEEVPYEEEKPE-EIQELPEEVRVVETVTEDGKPKKKKI-R 10260
                                .|||:..   :|:.|. |.:|...:||      |...|....: .
  Rat  3011 YLGHPLGNHWSGARIGKNSMATVTISN---DEDAPTIEFEEAAHQVR------EPAGPDATAVLS 3066

  Fly 10261 TRVIKKVKGDKQEVTKIETVEED-------DKQPETTVT-----VEEVPYEEE-KPEEIQELPEE 10312
            .:||:  :||:...:||.....|       |..|::.|.     |:.:.::.| ...|.:|..|.
  Rat  3067 VKVIR--RGDQNRTSKIRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHES 3129

  Fly 10313 VRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEENDKQ---------PETTVTVEEVP 10368
            ..:|....:.            ::.|.||   || ..||...|::         |...||:.:..
  Rat  3130 FSLVLGPDDP------------VEAVLGD---VT-TATVTILDQEAAGSLILPAPPIVVTLADYD 3178

  Fly 10369 YEEEKPEE-IQELP 10381
            :.||..:| :::.|
  Rat  3179 HVEELSKEGVKKAP 3192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
Fras1XP_038947596.1 VWC 27..86 CDD:214564
VWC 94..151 CDD:278520
VWC 158..>198 CDD:327433
VWC 224..277 CDD:278520
VWC 284..341 CDD:214564
VWC 368..415 CDD:327433
VSP 405..780 CDD:146106
VSP 728..1059 CDD:146106
FU 1045..1086 CDD:214589
Cadherin_3 1101..1197 CDD:406568 24/106 (23%)
Cadherin_3 1202..1309 CDD:406568 31/137 (23%)
Cadherin_3 1313..1440 CDD:406568 26/145 (18%)
Cadherin_3 1448..1576 CDD:406568 24/127 (19%)
Cadherin_3 1579..1693 CDD:406568 26/139 (19%)
Cadherin_3 1703..1813 CDD:406568 25/111 (23%)
Cadherin_3 1822..1940 CDD:406568 19/121 (16%)
Cadherin_3 1943..2061 CDD:406568 19/117 (16%)
Cadherin_3 2081..2181 CDD:406568 20/99 (20%)
Cadherin_3 2188..2295 CDD:406568 20/133 (15%)
Cadherin_3 2297..2408 CDD:406568 24/149 (16%)
Cadherin_3 2427..2539 CDD:406568 28/121 (23%)
Calx-beta 2555..2652 CDD:413355 19/113 (17%)
Calx-beta 2677..2763 CDD:413355 14/101 (14%)
caca <2782..>3049 CDD:273296 50/287 (17%)
Calx-beta 3041..3135 CDD:413355 23/101 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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