DRSC/TRiP Functional Genomics Resources

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Protein Alignment sls and IGSF22

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:XP_011518332.1 Gene:IGSF22 / 283284 HGNCID:26750 Length:1346 Species:Homo sapiens


Alignment Length:1459 Identity:333/1459 - (22%)
Similarity:543/1459 - (37%) Gaps:402/1459 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly 17086 VLSTQIVGNPPPKVTWYKDGKPVKNAKSDKDLHTLTLITPQKSE--KGEYTVKAVNPLGSVETTA 17148
            :||..:.|..|..:.......|..:.:|.        :.|.::.  .|.::..:..|...|....
Human     7 LLSPHVAGPAPTSLNALCSHAPPSSQESS--------VLPSRAGLLPGAHSDLSPAPTEEVVRRK 63

  Fly 17149 NLTIEE-----------PAGGNAEPPLFVERFEEQNVPQKGEIRLPAKVSGNPVPEVQW-LFNNT 17201
            :.:|.|           |||.:.  |.|||:.:....|:..:....|:|.||..|.:.| ..:..
Human    64 SSSIVEFFSLVTRSSNIPAGDSV--PEFVEKPQPVTAPEGDKAVFRARVQGNAKPHISWKRESGI 126

  Fly 17202 PLFPSERIQQVYDGENIELIIKDANPET--DSGDYKCIASNPIGKTSHGARVIV-----EVD--- 17256
            |:..|.:|  .||..|.|.::| ..|.|  ||.:|||||||......:...::|     ::|   
Human   127 PIKESAKI--FYDSINKEHVLK-LEPLTSDDSDNYKCIASNDHADAIYTVSLLVTEGQEKMDFKK 188

  Fly 17257 ----------------------------------------EVTFT---------KKLKKTITIEE 17272
                                                    |..||         |::||.:.:|.
Human   189 MLKKRAPPAPKKKQKKVANEKEMLEILSKVPKKDFEKVCMEYGFTDFRGLLRKLKEMKKKVEVEA 253

  Fly 17273 VQSL-TLECETSHVVTTKWF---------------FNGKELSGMDHRV----VVEDGKTHKLVIR 17317
            ::.| .||.:.:.|.||..|               ..|.|...:.:.:    |.:.|..:.|||.
Human   254 IRILKPLEDKETKVDTTVVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQMGTKYMLVIS 318

  Fly 17318 NTNLRDSGTYTCKVKKQETQSTVEVLQRKPDFIKVLEDYEVTEKDTAILDVELTTEATEVTWYKD 17382
            |.|:.|:|.|:..|..:...:.:.||.....|:..::..:|||:.||:.::.|:.:.....|..:
Human   319 NVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEMKPVKVTERQTAVFEIRLSKKEPNFVWKFN 383

  Fly 17383 GEKITPENK-NVEFIKDGKARRLVIRDVTIHDEGQYTCKIEGQECSCELVVIELPPEIVEPLNDV 17446
            |:::..::| .:...:||....|.|:|..:.|.|:::.:........:|.|..:|.:.|..|.:|
Human   384 GKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEAGNLVQKAQLTVDRIPIKFVSNLKNV 448

  Fly 17447 AVTKGENAVFEVELSKGDALVKWFKNGKEIVFNERIQLAIDGKKQSLRIVKAKPEDVGEYSV--- 17508
            .|.:...|..|.||:..|..::|.|:|:.::...:..:..:||:..|.|..|:..|.|||:|   
Human   449 RVKERSRACLECELTSKDVTLRWKKDGQLLMHGTKYSMNHEGKRAELIIEDAQLSDGGEYTVVAM 513

  Fly 17509 QVGEQT---SKAKLTVEEPLVDFVIRLPDITLATKTTDAEFTVQLSQPDVEVTWCKKGKPIKPNQ 17570
            |.|:.|   |.|.:||||.|......:.|:..|| .:.||..|.|:...||..|.|.||.|....
Human   514 QDGDPTEYYSTAIVTVEERLATVKSGMSDVHAAT-GSPAELCVVLNDEKVEGVWLKDGKEITDLP 577

  Fly 17571 KHEVFVEGTVRRLVIHDASDEDAGEISCVAENVTSSTKLCVEELKLPP-----VITSDKDQTIKV 17630
            ..::..:|.|.:|:......|..|:.:..|:...|...:.:.:   ||     |:.:.....|.|
Human   578 GMQIVKQGAVHKLIFPSMGPEHEGKYTFRAKGTESEASVFIAD---PPTIDPSVLEALAAHAITV 639

  Fly 17631 KENDDVTFTVKYTGVPTPEACWTTRKVVIPKSKRTIPTIDEQSAKLTIKKVVDDDEGEYTVKLVN 17695
            |........|.:.|.|.|:..|....:.:.:.:|......|..|.|||...|.:|.|...:||.|
Human   640 KVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKN 704

  Fly 17696 PVGEAEASLHLVIMRKPTAP-GTPQPLEIMHDSITLYWKAPEDDGKSEIIEYILEYQDVKEEKWT 17759
            ..|.|.|:|||.::.:|..| |..:.||:....:.:.||||:|:|...:.::|:|.:.|.::.|.
Human   705 DHGSATATLHLSVLDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKKSWI 769

  Fly 17760 EIRKI--KDTTYTISKLKIDTEYVFRSIAVNEVGPSPPSPLSPPIRLVPKVETKAPSVQEPLQDV 17822
            :|.::  |.|.::.:|::....|.||.:|||..|.|.|            :||:.          
Human   770 KIGEVDGKVTNFSTNKVEEGKAYQFRILAVNSEGVSDP------------LETEE---------- 812

  Fly 17823 VSELDKEVTLSCVFGGIP-EPKVTWKKNGQVFESRSIRYENRVAKYTIEKTTIETEATYTCVATN 17886
                        ||.|.| ||                                            
Human   813 ------------VFAGNPIEP-------------------------------------------- 821

  Fly 17887 EKGSAETSCRLKLQQKPVLEVEDKYLTQKLRTGSILTIPATVRGYPQPTVTWHKETIEQKTTKSV 17951
             .|.|.                                        ||.||              
Human   822 -PGFAS----------------------------------------QPQVT-------------- 831

  Fly 17952 TIETTETTSTYTVKKVTREQSGKYKVTATNESGTTYVECTVQVIDKPSRPQSLEIKDIKKDSIVL 18016
                                                                    |:.|:::.:
Human   832 --------------------------------------------------------DVTKEAVTI 840

  Fly 18017 EWTPPVDDGGLDIEKYTLEKCDVQNNVWMKVSDFNKDI---KSYAVQKLSMNAQYMFRVVAANPI 18078
            .|..|..|||..:..|.:|:....:|:|:.|   |||.   ....|..|..:.:|.|||:|.|..
Human   841 TWNAPTQDGGAPVLGYIVERRKKGSNLWVPV---NKDPIQGTKCTVDGLLEDTEYEFRVIAVNKA 902

  Fly 18079 GESEPTESDPVTITKKFEKPSPPRGPTTVSGMNDTSFNLAW-EPSETDGGSKIIEYIVEIREE-- 18140
            |..:|:......:.|...||........||..:::|.:||| ||:|.|..|   .||:|:|.|  
Human   903 GPGQPSVPSSSVVAKDPVKPPGLVQDLHVSDSSNSSISLAWREPAEGDPPS---GYILEMRAEDT 964

  Fly 18141 ---TETTYRSVGVTLGTVTNIHVEKVVRNKGYFFRIYARNEVGTSEAFETTEKIVLGRKITNDNE 18202
               ::.|...:..|..||..:     :..:.|||||.|.||.|..|..|..:.:          .
Human   965 KEWSKCTKIPISGTCYTVGGL-----IERQKYFFRIRAVNEAGVGEPVELDKGV----------R 1014

  Fly 18203 ALAPPSPPQNLRAPDVTSRSVTLDWEVPARNGGSEITGYCVE-------------KRSSTSTNWT 18254
            |:.||:.|:.    |:::|   |...:..|.|    |..|:.             ::....|...
Human  1015 AMPPPAAPKF----DLSAR---LKSHMVVRAG----TALCIHAAFSGSPPPDVIWQKDGVPTKGR 1068

  Fly 18255 KVITLDAHQLHYTIDNLKEKCEYWFRVSAENEVGLGAPAVTESISLKTHATVPSPPTGPLEARVL 18319
            :.||...:...:.|::.|......:|:..:||.|    .....|.::. |..|.|||        
Human  1069 ETITKSKNHSQFLINSTKRSDSGVYRILLQNEFG----EARYDIHVRV-ADFPRPPT-------- 1120

  Fly 18320 AANAHIFE---------WGLP---ESDGGAPLLGYHIAIRDMKKTMWIEVG-RVPAGVLKFQIRD 18371
              |..:||         |...   :.||.|   .|.|..||.....|.... ||.:.  |:.:..
Human  1121 --NLRLFEEVPNTVTLTWNHSPDVQEDGEA---HYIIMKRDASTATWYTAAERVFSN--KYTVTG 1178

  Fly 18372 LQENHEYMIRIFAKNEIGLSEPLESEEPY 18400
            |....:|..|:.|:||||.||||:|.:.:
Human  1179 LLPGRKYYFRVVARNEIGDSEPLDSRDTW 1207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352 10/67 (15%)
Ig_2 17078..17152 CDD:290606 10/67 (15%)
IG_like 17170..17253 CDD:214653 26/85 (31%)
Ig 17180..17250 CDD:143165 25/72 (35%)
I-set 17260..17342 CDD:254352 26/110 (24%)
IGc2 17274..17331 CDD:197706 19/76 (25%)
I-set 17347..17432 CDD:254352 18/85 (21%)
IGc2 17367..17423 CDD:197706 11/56 (20%)
I-set 17437..17521 CDD:254352 27/89 (30%)
Ig <17468..17521 CDD:299845 18/58 (31%)
I-set 17528..17611 CDD:254352 21/82 (26%)
Ig 17553..17602 CDD:143165 13/48 (27%)
I-set 17618..17708 CDD:254352 28/94 (30%)
Ig 17635..17708 CDD:299845 23/72 (32%)
FN3 17712..17791 CDD:238020 25/81 (31%)
I-set 17813..17898 CDD:254352 8/85 (9%)
Ig 17830..17894 CDD:143165 8/64 (13%)
Ig 17922..17994 CDD:299845 4/71 (6%)
FN3 17998..18090 CDD:238020 25/94 (27%)
FN3 18098..18189 CDD:238020 32/96 (33%)
FN3 18207..18298 CDD:238020 18/103 (17%)
FN3 18307..18398 CDD:238020 32/103 (31%)
IGSF22XP_011518332.1 I-set 87..177 CDD:254352 30/92 (33%)
Ig 104..>164 CDD:299845 23/62 (37%)
I-set 255..343 CDD:254352 20/87 (23%)
Ig 264..338 CDD:299845 17/73 (23%)
I-set 349..434 CDD:254352 18/84 (21%)
Ig 372..434 CDD:143165 11/61 (18%)
IG_like 446..529 CDD:214653 25/82 (30%)
Ig 456..512 CDD:143165 18/55 (33%)
IG_like 541..618 CDD:214653 21/77 (27%)
IG_like 637..717 CDD:214653 26/79 (33%)
Ig_Titin_like 647..717 CDD:143225 23/69 (33%)
FN3 721..813 CDD:238020 30/125 (24%)
FN3 822..912 CDD:238020 31/202 (15%)
FN3 923..1008 CDD:238020 30/92 (33%)
IG_like 1032..1112 CDD:214653 14/87 (16%)
Ig_Titin_like 1042..1112 CDD:143225 11/73 (15%)
FN3 1116..1203 CDD:238020 31/101 (31%)
I-set 1233..1322 CDD:254352
Ig 1256..1322 CDD:299845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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