back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sls and Zan

DIOPT Version :9

Sequence 1:	NP_001261304.1	Gene:	sls / 44013	FlyBaseID:	FBgn0086906	Length:	18468	Species:	Drosophila melanogaster
Sequence 2:	NP_035871.2	Gene:	Zan / 22635	MGIID:	106656	Length:	5420	Species:	Mus musculus

Alignment Length:	1890	Identity:	365/1890 - (19%)
Similarity:	577/1890 - (30%)	Gaps:	700/1890 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly 15557 PEEIPVEYKITTTVLEPEDAPKEHQVKVIDFDERQETTEEV----------IEEKVVTRKKKPKP 15611
            |..:.::.:|.::.|.|...|.|..|..:..::....|:..          .||..:..:....|
Mouse   539 PCRVLLQTEIPSSPLLPPTGPSESTVPTLPMEQPTSPTKATTVTIEIPTTPTEEATIPTETTTVP 603

  Fly 15612 QQPEEFEVTLKEPKEEQIQPDVVSAEISLPIEEPEQKPEQYEVELKITQTTPEEPNDVQIAVKEK 15676
            .     ||....|||..|.|     |:::|.|.....||:.   :..|:.|| .|.||..|..|.
Mouse   604 T-----EVINVSPKETSIPP-----EVTIPTEVITVSPEEI---ISPTEVTP-VPTDVTAAYVEA 654

  Fly 15677 VKTKPVKKVKEDKIVVVEAEEEKQPVEETIVEVEKQEEKKKSEKPKSYEFKISETQSIEEKPIEV 15741
            ....|              ||...|.|.||:                               .||
Mouse   655 TNASP--------------EETSVPPEVTIL-------------------------------TEV 674

  Fly 15742 AEEAPEETPKVVEKKVAEKFDSYEFTLKETDEEKVITVDDQPEEEAPVEVVFKKKPKEPEAVEAE 15806
            ...:||||....|..:.    ..|.|...|.|..:.|       |.|.      .|.|...|..|
Mouse   675 TTVSPEETTVPTEVPIV----LIEATAFPTGETTLYT-------EVPT------VPTEVTGVHTE 722

  Fly 15807 FVMTEPKIVEETSVETAIKQKKTKKPKKDEEEAQLAIKVVESEAPVAEEVFSEAPESKIVEEEVI 15871
            .....|   |||||.|                          |..::.||.:.:|     ||..:
Mouse   723 VTNVSP---EETSVPT--------------------------EETISTEVTTVSP-----EETTL 753

  Fly 15872 AEEKPKEFTIRVSESEPKPEEPSVEQFTVKKRKPSVTFADEPATEIVIKESKPAEVVTEDAHIKT 15936
            ..|.|   |:....:...|||.||        .|..|......||:       ..|.||...:.|
Mouse   754 PTEVP---TVSTEVTNVSPEETSV--------PPEETILTTLYTEV-------PTVPTEVTGVHT 800

  Fly 15937 KKPKKKVTDVEAEELKIKITEEVPQEIPILEEVSEEEVITETKKTAPVVEEKTYKIGIKETEPEK 16001
                 :||:|..||..:...|.:..|:   ..||.||....|:  .|.|..:...:        .
Mouse   801 -----EVTNVSPEETSVPTEETISTEV---TTVSPEETTLPTE--VPTVSTEVTNV--------S 847

  Fly 16002 PAEAIVEEEEPVVTEPIEEAPKPEVFEEHKVRVIEETPRELVEEVIEEEVKVIRRKKPKPEIKEE 16066
            |.|..|..||.::||....:|:..||.      ||.|  .|..||:...:          |:...
Mouse   848 PEETSVPPEETILTEITTVSPEETVFP------IEGT--TLPTEVLTVPI----------EVTTF 894

  Fly 16067 PEAEVTVSTPKPVEEVEA----TSSIAVIPEQ---PTEEEAADLKITIIEEETPPQELVQEIEEI 16124
            |..|.||.|..|....|.    |....|.||:   |||      ..|::....||:|..
Mouse   895 PTGETTVPTEVPTVSTEMTGVHTEVTTVFPEETSIPTE------VATVLPASIPPEETT------ 947

  Fly 16125 EIVEEPKAPEEQPTDFTFATKDSEKKPTVEELPEEQVTIQKKKKKAPVPEVVEEPEAEFLVKPKT 16189
                       .||:.|             ..|.|:.||..:....|...:
Mouse   948 -----------TPTEVT-------------TTPPEETTIPAEVTTIPPVSI-------------- 974

  Fly 16190 PVQEVTEEAKITKSKKPVKEEEAAAELKVTITEEIPTEPEVQEIIEEIEEIEEEKPAEYVIEVKE 16254
            |.:|.|...::|.:  |.:|        .||..|:.|.|.|     .|...|...|.    ||..
Mouse   975 PSEETTTPTEVTTT--PPEE--------TTIPAEVTTVPPV-----SIPSEETTTPT----EVTT 1020

  Fly 16255 SQPEAVEDKEVSLPKKKPKAPIVEEPEAEITLKPKVKS---EEVQEEAKIVKKKPKKIDEVAVAD 16316
            :.||     |.::|.:....|.|..|..|.|:..:|.:   ||....|::....|         :
Mouse  1021 TPPE-----ETTIPAEVTTVPPVSIPSEETTIPTEVTTVPPEETTIPAEVTTTPP---------E 1071

  Fly 16317 ELTVKVEEEVVPEPIVEEEVIEEFEIKKKPKEPEPEDIVDAAIVKLKKPEPVDADEVVAEVTLKP 16381
            |.|:..|...||                 |....||:......|....||.....   .|||..|
Mouse  1072 ETTIPTEVTTVP-----------------PASIPPEETASLTEVTTTPPEETTTP---TEVTTVP 1116

  Fly 16382 KAKTEVTEEEFSVDVKLPKEKKVTEETSDQTVQLKKKKKPQKPVEEAADELKLQQTVV--EERPV 16444
            ..||.:..|..:|    |......|||   ||          |.||..  :..::|.|  :|..:
Mouse  1117 PEKTTIPTEVTTV----PPASIFPEET---TV----------PPEETT--IASEETTVSTQETTL 1162

  Fly 16445 EIEEEEIIEEAVVIRKK-PKKPFEPTVEDLEE----TEFSLSFKKPHT---------INEGVEEA 16495
            ..|:..:.:.::..|.. |..|..|....|.:    :.|||:   |.|         .|..:|..
Mouse  1163 LTEQSAVTQTSIACRPPCPSPPLMPIGPLLSKPPGVSMFSLA---PTTGVSTTESCPPNAHIELC 1224

  Fly 16496 ATVLKKRPVKPT---------------------TLDEAAAELSIKRQEEEYEEGEDIEEFVVSQQ 16539
            |........||:                     .::|::.  :.....:.|:.||  |.|..:..
Mouse  1225 ACPASCESPKPSCQPPCIPGCVCNPGFLFSNNQCINESSC--NCPYNNKYYKPGE--EWFTPNCT 1285

  Fly 16540 RKPKPL-------QITEEDEEAYTVKKLKRRKQVDIP-------EYADVENVTFRARS------- 16583
            .:.:.|       ||::..  .:||.:||..:....|       .|.|:..|||..|.
Mouse  1286 ERCRCLPGSLMECQISQCG--THTVCQLKSDQYQCEPYGKATCLVYGDLHFVTFDERHIGFTGTC 1348

  Fly 16584 ----TKT-KEDVDQEFNIALDSYAE--EEISMSGKVKLKKPIKKTFSEAADEAKIKIIQDFDDGE 16641
                |:| ....|..|.|..::...  |.:|...||.:..|          |..:.:|    .|.
Mouse  1349 TYILTQTCSNSTDHFFRITANTEERGVEGVSCLDKVVISLP----------ETTVTMI----SGR 1399

  Fly 16642 EPIIEEIRDDEDTIDEVEEPEEY------FVE--------------------------------- 16667
            ..:   |.|.|.|:..:...:.|      |||
Mouse  1400 HTL---IGDQEVTLPAILSDDTYVGLSGRFVELRTTFGLRVRWDGDQQLFVTVSSTFSGKLCGFC 1461

  Fly 16668 ----------------ELPPDEVDFKLKPKKHPKPAYSVQDEEEEQFLIGIRHPKRDSVTYDEDS 16716
                            .:..||.:.:|        ::.|:::|::.::......|::..:.|...
Mouse  1462 GNYDGDSSNDNLKSDGMMTHDEEELRL--------SWQVEEDEDKDWVSSRCQKKKNPPSCDAAL 1518

  Fly 16717 LTFKKKRKVVQQLFNEDG---ASLNITREMNVEESENL-NIMYSICNYIADNNEAINLVEGEKVT 16777
            .:.....|:..||.|..|   |.|     ::::.|..| |.:..:|::           :|.:..
Mouse  1519 GSTMSGPKLCGQLVNPSGPFEACL-----LHLKASSFLDNCVTDMCSF-----------QGLQQK 1567

  Fly 16778 VVGRHSSEWWYVKKSTTEEEGWVPAQYLMEPEEYAQYVQNKLHEKIDKLPVFERPGPEDKPIAPR 16842
            :....|:     ..:|.::.|: |.:...|| ::...|    ..|..:..:..:|.|
Mouse  1568 LCAHMSA-----MTATCQDAGY-PVKPWREP-QFCPLV----CPKNSRYSLCAKPCP-------- 1613

  Fly 16843 FIEKLQPI----HTPDGYTVQFECKVEGNPRPQIAWFRETAIIKPSQDFQMFYDDDNVATLIIRE 16903
              |...||    |..|......||    :|
Mouse  1614 --ETCHPISTTQHCSDKCVEGCEC----DP----------------------------------- 1637

  Fly 16904 VFPEDAGQFTVVAKNAAGFTSSTTELIVESPLSDHGSDATALSRRSMSRESSLADILEGIPPTFS 16968
                             ||..|.:|.:   |.|..|  .|:...|....:.      :...|...
Mouse  1638 -----------------GFILSGSECV---PSSQCG--CTSFQGRYFKLQE------QWFNPDCK 1674

  Fly 16969 K------------KP---KAQYVDENTNVILECR------LVAVPEPDIVWTFNGEDIDEEEIKN 17012
            :            ||   |||......|.:|.|.      .:...:|..: ||:|.
Mouse  1675 EICTCESHNHILCKPWKCKAQEACSYKNGVLGCHAQGAATCMVSGDPHYL-TFDGA--------- 1729

  Fly 17013 VRIVTESDMHMY---CSVVHISKV-KKSQEGTYEVIATNREGEARLPIT----LKVRTTDKEAPQ 17069
                    :|.:   |:.|..... .||||..:.|.|||...:..|.::    :.|:..|.:...
Mouse  1730 --------LHHFMGTCTYVLTQPCWSKSQENNFVVSATNEIHDGNLEVSYVKAVHVQVFDLKISM 1786

  Fly 17070 ILEPLRNMVIREGESVVLSTQIVGNPPPKVTWYKDGKPVKNAKSDKDLHTLTLITPQKSEKGEYT 17134
            .          :|:.|||:.|.|                              :.|....:|..|
Mouse  1787 F----------KGQKVVLNNQRV------------------------------VLPVWPSQGRVT 1811

  Fly 17135 VKAVNPLGSVETTANLTIEEPAGGNAEPPLFVERFEEQNVPQKGEIRLPAKVSGNPVPEVQWLFN 17199
            ::.......:.|...|.:               |::.:::.   |:.:|:..:|: :..:...:|
Mouse  1812 IRLSGIFVLLYTNFGLQV---------------RYDGRHLV---EVTVPSSYTGS-LCGLCGNYN 1857

  Fly 17200 NTPLFPSERIQQVYDGENIEL-----IIKDANP-------------ETDSGDY---KC-IASNPI 17242
            |..:..:.|:.....|.::.|     |::.::|             ::|..|.   || |..||:
Mouse  1858 NNSMDDNLRVDMKPAGNSLLLGAAWKILEASDPGCFLVGGKPSRCADSDMDDVWTKKCAILMNPL 1922

  Fly 17243 GKTSH 17247
            |..|:
Mouse  1923 GPFSN 1927

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.