DRSC/TRiP Functional Genomics Resources

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Protein Alignment sls and Vwf

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_035838.3 Gene:Vwf / 22371 MGIID:98941 Length:2813 Species:Mus musculus


Alignment Length:792 Identity:137/792 - (17%)
Similarity:258/792 - (32%) Gaps:258/792 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly 14223 LQDYIQKLIE-QDIPKTELEKYEKIDLDEPVKMKRKPIKKVKQSEEQPK--------------EE 14272
            |.:.:|..:: ||.|..|:           ...:..|.||:..|.:.|.              |.
Mouse  1183 LDELLQTCVDPQDCPVCEV-----------AGRRLAPGKKITLSPDDPAHCQNCHCDGVNLTCEA 1236

  Fly 14273 TEE------PIEDKPVEKISEYSEVDSDEPKL-------------------------TVAVKEFI 14306
            .:|      |..|.||...:.|.| |:.||.|                         ...:|.|:
Mouse  1237 CQEPGGLVAPPTDAPVSSTTPYVE-DTPEPPLHNFYCSKLLDLVFLLDGSSMLSEAEFEVLKAFV 1300

  Fly 14307 PEKPE-----EKPFEIVVLEE--------TVESKREPDEEGKVREKVVKTKKIKQNRGSVEVVHD 14358
            ....|     :|...:.|:|.        .:::::.|.|..::      |.:||.....|....:
Mouse  1301 VGMMERLHISQKRIRVAVVEYHDGSRAYLELKARKRPSELRRI------TSQIKYTGSQVASTSE 1359

  Fly 14359 IVE--------EIDTDTNESVITVTTTVPTETPDQDQPSVKQKRTKKIKKDEVEDFVKRVIEEEA 14415
            :::        :||. ...|.||:..|...|.|...:..|:..:..|.||               
Mouse  1360 VLKYTLFQIFGKIDR-PEASHITLLLTASQEPPRMARNLVRYVQGLKKKK--------------- 1408

  Fly 14416 PQPEGSVDLVVIEDFVPKPSSEKRKKKPIKDKHTSVEEETPHEDEVLLIESVPEDSPLSDDLIT- 14479
                    ::||...:...:|.|:.:        .:|::.| |::..|:..|.|.....|:::: 
Mouse  1409 --------VIVIPVGIGPHASLKQIR--------LIEKQAP-ENKAFLLSGVDELEQRRDEIVSY 1456

  Fly 14480 VVDSVPIEEEPENKVNQIEDTKKPE----KKKKPKPSAKILEE---------------NVPEDTV 14525
            :.|..|....|.........|..|.    ....||..:.:|:.               |..::.|
Mouse  1457 LCDLAPEAPAPTQPPQVAHVTVSPGIAGISSPGPKRKSMVLDVVFVLEGSDEVGEANFNKSKEFV 1521

  Fly 14526 EKPLEALHTDSDLEKPDVQEFSISI-----------KEEEQKHTHPEKKKSSKISSEQPKQPSTE 14579
            |:.::.:....|..:..|.::|.::           |||..:|..       :|..:...:.:|.
Mouse  1522 EEVIQRMDVSPDATRISVLQYSYTVTMEYAFNGAQSKEEVLRHVR-------EIRYQGGNRTNTG 1579

  Fly 14580 QYEISVTEHDLKPEE----EKPFTVQVIQSETNVEETKDDTGKVHKQVTTKRMLRRPAGEG-EIE 14639
            |....::||...|.:    |.|..|.::......:|.|...|.:  ||.       |.|.| ...
Mouse  1580 QALQYLSEHSFSPSQGDRVEAPNLVYMVTGNPASDEIKRLPGDI--QVV-------PIGVGPHAN 1635

  Fly 14640 IIEVVRDDQPEAEITIVEYEPEPVNQDEKPKEPKKKTRKVKKDDIHDYIQKLIELETPKTELE-- 14702
            :.|:.|..:|.|.|.|.::|..|                               .|.|...|:  
Mouse  1636 MQELERISRPIAPIFIRDFETLP-------------------------------REAPDLVLQTC 1669

  Fly 14703 -KYEKIEFEPIVKDKPLDSPIDV---------LDESPKEVQKKDKKSRSTKV---PNEETPVQEQ 14754
             ..|.::...:........|:||         |.||..:..|...|:..:|.   |:.......|
Mouse  1670 CSKEGLQLPTLPPLPDCSQPLDVVLLLDGSSSLPESSFDKMKSFAKAFISKANIGPHLTQVSVIQ 1734

  Fly 14755 YAKVNVVEEEAPEQPEIPVQILEVKPVEVDVKEVITEDGKPVQEKTTKRVLKKIGPEEQTTFKIT 14819
            |..:|.:        ::|..:::.|.....:.:::.::|.|.|          ||  :...|.:.
Mouse  1735 YGSINTI--------DVPWNVVQEKAHLQSLVDLMQQEGGPSQ----------IG--DALAFAVR 1779

  Fly 14820 MIESE-------DNDSVTVI--------VDEEPEIAS-------PQSIEEHPEQSKEKLAPKPKK 14862
            .:.|:       .:.:|.:|        ||...:.|.       |..:.:..::::.::...|..
Mouse  1780 YVTSQIHGARPGASKAVVIIIMDTSLDPVDTAADAARSNRVAVFPVGVGDRYDEAQLRILAGPGA 1844

  Fly 14863 TVRKVKKDDLSD 14874
            :...||...:.|
Mouse  1845 SSNVVKLQQVED 1856

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064 60/346 (17%)
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
VwfNP_035838.3 VWD 35..179 CDD:278521
C8 218..292 CDD:214843
TIL 295..348 CDD:280072
VWC 350..>394 CDD:302663
VWD 377..540 CDD:214566
C8 580..648 CDD:285899
TIL 652..707 CDD:280072
Amino-terminal 764..787
E1 788..833
CX 826..853
VWD 856..1011 CDD:214566
C8 1053..1127 CDD:214843
TIL 1146..1196 CDD:280072 3/12 (25%)
VWA_N2 1198..1276 CDD:292782 18/89 (20%)
VWA 1277..1449 CDD:214621 34/210 (16%)
VWA 1498..1658 CDD:278519 34/175 (19%)
VWA 1691..1860 CDD:278519 31/186 (17%)
VWD 1950..2102 CDD:278521
C8 2136..2199 CDD:285899
TIL 2203..2254 CDD:280072
E2 2216..2261
VWC 2257..2321 CDD:214564
VWC 2431..2494 CDD:214564
Cell attachment site. /evidence=ECO:0000250 2507..2509
VWC 2582..2644 CDD:302663
CT 2727..2808 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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