DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and Otog

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:XP_017177514.1 Gene:Otog / 18419 MGIID:1202064 Length:2917 Species:Mus musculus


Alignment Length:2320 Identity:413/2320 - (17%)
Similarity:649/2320 - (27%) Gaps:898/2320 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  2631 YDKLHEGQHVLLEAQVEPRADPNLRIEWFKNGISLTTGSRIRSTFDFGLVTLSINGLRADD--SA 2693
            ||:  ||..:.|  ||:.|        |.::.:.|.      .||         ||...||  |.
Mouse   622 YDR--EGLRLYL--QVDQR--------WVEDTVGLC------GTF---------NGNTQDDFLSP 659

  Fly  2694 IYTCKATNQV-GEAVSTSSLKIE----------DRHWLQAESLHPDSLPRI-GELEAPKEGRPEA 2746
            :...::|.|: |.:..|.|..:.          |.| |||.|....|...: |||.||.... .:
Mouse   660 VGVPESTPQLFGNSWKTLSACVPLVPGSLLDPCDVH-LQAASYALQSCSVLTGELFAPCSAY-LS 722

  Fly  2747 PEPTYETPVFITHLNNIECKESDNVRFECNV-EPARDPTMSIEWFY------NGQPLQAAAKFKS 2804
            |.|.:|           :|:     |..|.. :|....|::   .|      :|.|:...|...:
Mouse   723 PIPYFE-----------QCR-----RDACRCGQPCLCATLA---HYARLCRRHGLPVDFRAHLPA 768

  Fly  2805 IYDFGYCALDLTNSYAENSGVYTCKAT------------NSKGSATTSGTLK-CTGGKTMFLDTQ 2856
                  |||....:...:..|..|..|            |..|:.:....:: ||.....|||||
Mouse   769 ------CALSCEATKEYSPCVTLCAPTCQDLASPDVCGANGGGNFSREECVEGCTCPPDTFLDTQ 827

  Fly  2857 ------------HPQGEAGLEAVQETEEELANRYTSKTTKPETQYPP------------------ 2891
                        |.||                          ..|||                  
Mouse   828 ADLCVPRNQCSCHFQG--------------------------VDYPPGDSDIPSLGHCHCKDGVM 866

  Fly  2892 ------PVWTKPL-QAEFHLSEAQPIHLEANVEPKEDPNLFIEWYFNGKMLN------------- 2936
                  |....|. |...:.||..|           ||.|..|.....::||             
Mouse   867 SCDSRAPAAACPAGQVFVNCSELHP-----------DPELSRERTCEQQLLNLSVPARGPCLSGC 920

  Fly  2937 --------HGSRFKMTSEFGFVTMDMIEVYARDQGIYTCKAYNKAGEAFTSTTIFCSSKENIIES 2993
                    ||.......|.. .|....|.:..||.:.:|..              |..:....:.
Mouse   921 ACPQGLLRHGDACFPPEECP-CTWKGKEYFPGDQVVSSCHT--------------CVCQRGSFQC 970

  Fly  2994 TQHPKGAEGLEQIQDLEDSLRKDGSKPEQPDLGIPPRF-----------TTEF---VNIADI--- 3041
            |.||           ...:....|.:..:...|:|..|           |:|.   |.:.|:   
Mouse   971 TLHP-----------CASTCTAYGDRHYRTFDGLPYDFVGACKVHLVKSTSELSFSVMVEDVNCY 1024

  Fly  3042 GEGELAHFEANLIPVGDQSMVI----------EWFYNGKVLEASHRVR----TIYAFGTVALEVL 3092
            |.|.:.. ::..|.|| .|::|          |.|.:.|  :|.|..|    |:..|....:.:|
Mouse  1025 GSGVICR-KSISINVG-SSLIIFDDDSGDPSPESFLDEK--QAVHIWRAGFFTLVHFPREHITLL 1085

  Fly  3093 ----------------GTKIEDTGTYTCRATNKHGTAEISCNL---------------ECVDKPR 3126
                            |..:...|.:..:..|:..|.|   ||               ||.|.| 
Mouse  1086 WDQRTTVHVQAGPQWQGQLVGLCGNFDLKTINEMRTPE---NLELTNPQEFGSSWAAVECPDTP- 1146

  Fly  3127 GQKPRFTSHIQPLEGLKDGQSAHFECTLIPVNDPDLKVEWYHNGKLMRHSNRIKTVSDFGYVVLD 3191
              .||.|                  |.|.|:.:|..:.|.   |.|      :..|.:..:.|:|
Mouse  1147 --DPRDT------------------CVLNPLREPFARKEC---GIL------LSEVFETCHPVVD 1182

  Fly  3192 ISYLQDHDSGEYVCRAWNKYGEDFTRTTLNCG-GRGG---VFYDSLQPDSLQRIRELECPQGQQA 3252
            :::.               |....|.|   || .|||   .|..|:...:.|.     |..|...
Mouse  1183 VTWF---------------YSNCLTDT---CGCSRGGDCECFCASVAAYAHQC-----CQHGVVI 1224

  Fly  3253 DTSAPLV------------AEPPKFITQIVDVTKLVEGQSAHFEARLTPITDPDLVVEWYFNGKK 3305
            |...|.:            .:.|..::.:.....||          .|...|.|:.:   ...:.
Mouse  1225 DWRTPRICPYDCDFFNKALGKGPYQLSSVAAGGTLV----------ATKAVDSDIAL---VRAED 1276

  Fly  3306 LPHGHRFRTFHDFGIVILDILYCYEENSGVYEARARNKYGEDVTRASLKCASKSSLILDSQLPRG 3370
            |..|       |....:|        .:.:|:|:|   :..||  .||:.|.:.:..|.:     
Mouse  1277 LAPG-------DISSFLL--------TAALYKAKA---HDPDV--VSLEAADRPNFFLHT----- 1316

  Fly  3371 MEGGLEKIANLEYSMVR-TREETTEE------TKGKAPVFTVPLENIENLREGENAHFEARITPA 3428
                   .||....:.: .|:|...:      .:|......|.||::  .:.|...|       :
Mouse  1317 -------TANGSIGLAKWQRDEAFHQHASFSLHRGTWQAGLVALESL--AKPGSFLH-------S 1365

  Fly  3429 DDPKLKVEWYWNGRPLKAGSRFRTFCDFGFVILEISPV---YPEDSGEY---------SCRAINE 3481
            ...:|.:..|.:....:.|:.||        :|:..|:   ||.....|         :||    
Mouse  1366 SGLELALRAYEHTEVFRGGALFR--------LLDAKPLGAAYPTCEWRYDACASPCFQTCR---- 1418

  Fly  3482 YGEAVTTATMKIQGKRSIIMESQLPKGMEGTIDRIAELEG------------LGSRSTEFVPDDD 3534
              :...|:...:......:.....||.::....|...||.            ||:.:  .||   
Mouse  1419 --DPRATSCQDVPRVEGCVPVCPTPKVLDEVTQRCVYLEDCVEPAPRGPTETLGNET--LVP--- 1476

  Fly  3535 TGKPPEFITSPFDMVIGENALAHFECRLQPI-------NDPSMRVDWFHNGKALWAGSRIKTIND 3592
             |:.|...::...:..|....:.:.....|:       |.|....:    |:|...||...|:  
Mouse  1477 -GQVPPTTSAEQQLPQGLPGASAYSPAPVPVAPPTSAPNPPMAATE----GQAPSPGSTQPTL-- 1534

  Fly  3593 FGFVILEIAGCYQRDSGLYTCKATNKHGEATVSCKLQVKGRQGIVMEPQLPSNFRTGTESLQKLE 3657
                        |...||.|......|.|||..                        .|....|.
Mouse  1535 ------------QTPLGLTTSNFPAGHTEATAR------------------------EEGAASLL 1563

  Fly  3658 ETMHKREELVTEDEQPNPPKFTEEIKDNLDVPEGGPIHFDCRVEPVGDPTMRIEWFYNGHVMATG 3722
            .|.|             ||.|:..:..:|.:|..|.:                            
Mouse  1564 TTSH-------------PPGFSSSLPSSLQMPTSGIV---------------------------- 1587

  Fly  3723 SRVHQLNDFGFIALDVDYIYARDSGEYTCRATNKWGTATTSAKVTCKGKHNIVYESQLPEGMTSE 3787
                                   ||          .|.||...:|..|..|....|:.|      
Mouse  1588 -----------------------SG----------ATETTKVTITFTGSPNTTVASRSP------ 1613

  Fly  3788 KLKELERGRIPEAPKVVEEVFGP-PKFTTQITSVTVDEAEAVRFECQVEPKTDPSLRVEWYRNGK 3851
                                  | |:|.....:|||...::  |..:..| ..||..  |..:.:
Mouse  1614 ----------------------PIPRFPLMTKAVTVPSHDS--FPVKTTP-LQPSWL--WSLSSR 1651

  Fly  3852 PLPSGHRYRNIFDMGFVSLDILYVYGEDSGEYVCRAINNYGEDRTRATV---------SCKKLPT 3907
            |:.|         :|..|..     ....|.::..|:.... ::|..::         |.:.|..
Mouse  1652 PMTS---------LGATSWP-----PTSPGSHLSTAVTKVA-NKTMTSLSVLAQSTSSSSQPLAA 1701

  Fly  3908 ILLQNQVPRGMKRSDALTQMEATIKKYTSEVHLTEDDLFDPDRKQP---PRFVTQIKEQLTLTEM 3969
            :...::.|.....:..|..:.||.|.......|||..:..|....|   |.     ..|.|.|..
Mouse  1702 VTTAHRAPASPLVTKGLEVVSATEKGEAGHSQLTELPVSPPPSPAPIDLPH-----PAQHTTTAP 1761

  Fly  3970 AVTKFECQLAPVGDPNMKVEWFFNGKPLLHKNRFQPIYDFGYVAMNFGWVYPEDSGEYVCRATNL 4034
            ..:.....:...|.|:                                      :|.:...||.|
Mouse  1762 GPSALSPGILAAGSPS--------------------------------------TGAHRPGATAL 1788

  Fly  4035 YGKDETRAIIKVSGKPGIVYDSQLPAHMQSIDRIREMEASWQVVPDEVDPDAKPRTKPVFVSKLE 4099
            ...:.||....:||.|   .|:.||..............|...:|  ..|.....|.......:.
Mouse  1789 ASLEPTRPPHLLSGLP---LDTSLPLAKVGTSAPVATPGSKGYIP--TPPPQHQATTLATAMTVS 1848

  Fly  4100 P--QTVEEGDPARFCVRVTGH---PRP-------------RVMWLINGHTVVHGSRYKLTNDGMF 4146
            |  |::....|....|....|   |:|             ..:......:|:.|           
Mouse  1849 PLTQSLSLTVPLMSAVEEQAHSPSPKPPQGTGMAPDQMLGATLPSFGASSVIAG----------- 1902

  Fly  4147 HLDVPKTRQYDTGKVEVIARNSVGESIATTELKVVARSDDYRNVLKNSPRPWYDYELAAYQKERQ 4211
               ||.|       |....|.|..:..|....||             ||.     .|.:...:..
Mouse  1903 ---VPPT-------VSAAPRKSTTQRAAILSKKV-------------SPP-----TLISDSVQGG 1939

  Fly  4212 ENELEKVFDERKQVLSEQSSHTLKGVEHLKPKQYKPPTPDWQQNVKAKKSEDYYNKLQTLETEQL 4276
            ..||..:.......|:.::.....|...|.|..|.      ...|.|:          |...|..
Mouse  1940 FTELTPIVSHTVTPLATEAEGPRAGTVPLVPTTYS------LSRVSAR----------TASREGP 1988

  Fly  4277 LKETNLRRDTHQYAIPGEKVVSSSQAKGMAQSYEENLQEKTSTTEVQAAPPKGIAQPS---ESSV 4338
            |  ..|.:....|..|.          |: |..|:.:::.|:....::||.|.||:.|   |.:.
Mouse  1989 L--VLLPQLAEAYGTPA----------GL-QPQEDLVRQATTEQSGRSAPAKSIAEESMEAEVNT 2040

  Fly  4339 HGREVHMNKQQQVQKE-IQGDLEITRKITATETTEVEHKGTIQERVVQGPVKPAKAPVFTKKIQ- 4401
            ....|.:.:|..|:.. ::|.|     |...:|          :...||.|:| :..|....:: 
Mouse  2041 SATCVPIAEQDCVRHICLEGQL-----IRVNQT----------QHCPQGAVRP-RCGVLGLAVRV 2089

  Fly  4402 -------------PCRVFENEQAKFEVEFEGEPNPTVKWYRESFPIQNSPDLQIHTFSGKSILII 4453
                         .|.:|                               |||...||.|....:.
Mouse  2090 GGDRCCPQWECACRCSIF-------------------------------PDLSFVTFDGSHAALF 2123

  Fly  4454 RQ-VFVEDSAVFSCVAENRGGTAKC-SANLVVEERRRAGKGGIQPPSFVTTIQSTTVATGQLA-- 4514
            :: ::|...:....::.:   ...| ||||          |.:..|.|...|.:.|.....::  
Mouse  2124 KEAIYVLSQSPDETISVH---VLDCKSANL----------GHLNWPPFCLVILNVTHLAHHVSID 2175

  Fly  4515 RFDAKVTGTRPLD--VYWLKNGMKIQPSIKFKMLEEDSVHTLLIIEP------FAEDSGRYECVA 4571
            ||:.|||    :|  |.|       .|..::....||:.|..::..|      :...||   .:.
Mouse  2176 RFNRKVT----VDSQVVW-------PPMSRYGFRIEDTGHMYIVRTPSHIQIQWLHSSG---LMI 2226

  Fly  4572 VNAAGEAR---------CDGDCIVQSPSKPEKPTTPGSEKAPHIVE-QLKSQTVEEGSKVIFRCR 4626
            :.|:..::         ||||.......|.........:.||.:.. |:.|....||..   |.|
Mouse  2227 LEASKVSKTQGHGLCGICDGDAANDLTLKDGSVLGEAEDPAPFLDSWQVPSSLTSEGQT---RFR 2288

  Fly  4627 VDGKPT----PTARWMRG------ENFVKPSRYFQM-SRQGEYYQ 4660
            .|...|    |..|.:..      .:||.|..:.:: .|..:|.|
Mouse  2289 PDSCATADCSPCLRMVSNRTFSACHSFVSPESFCELWIRDTKYVQ 2333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352 22/85 (26%)
IGc2 2636..2704 CDD:197706 17/70 (24%)
I-set 2754..2844 CDD:254352 17/108 (16%)
Ig 2771..2840 CDD:143165 16/87 (18%)
IGc2 2908..2974 CDD:197706 15/86 (17%)
I-set 3029..3120 CDD:254352 28/152 (18%)
Ig 3057..3116 CDD:143165 17/88 (19%)
I-set 3130..3220 CDD:254352 16/89 (18%)
Ig 3148..3219 CDD:143165 12/70 (17%)
I-set 3263..3354 CDD:254352 16/90 (18%)
I-set 3401..3493 CDD:254352 18/103 (17%)
Ig 3429..3490 CDD:143165 13/72 (18%)
I-set 3539..3630 CDD:254352 18/97 (19%)
Ig 3556..3625 CDD:143165 16/75 (21%)
I-set 3676..3767 CDD:254352 10/90 (11%)
IGc2 3690..3758 CDD:197706 3/67 (4%)
I-set 3811..3900 CDD:254352 17/88 (19%)
Ig 3828..3899 CDD:143165 12/70 (17%)
I-set 3954..4046 CDD:254352 12/91 (13%)
Ig 3963..4042 CDD:299845 10/78 (13%)
I-set 4092..4180 CDD:254352 16/105 (15%)
Ig 4102..4172 CDD:299845 13/85 (15%)
I-set 4394..4483 CDD:254352 15/104 (14%)
Ig 4411..4480 CDD:143165 9/70 (13%)
I-set 4497..4581 CDD:254352 20/102 (20%)
Ig 4519..4580 CDD:143165 14/77 (18%)
I-set 4604..4693 CDD:254352 17/69 (25%)
Ig 4621..4691 CDD:299845 12/51 (24%)
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
OtogXP_017177514.1 VWD 145..292 CDD:365869
C8 343..405 CDD:370094
TIL 420..467 CDD:366828
VWC 469..>504 CDD:327433
VWD 507..659 CDD:365869 16/63 (25%)
C8 706..765 CDD:370094 16/78 (21%)
TIL 773..837 CDD:366828 12/63 (19%)
TIL 877..939 CDD:366828 13/72 (18%)
VWD 970..1124 CDD:214566 32/171 (19%)
C8 1159..1233 CDD:214843 22/105 (21%)
Fascin <1298..1389 CDD:390083 21/121 (17%)
PHA03247 <1459..1974 CDD:223021 122/771 (16%)
VWD 2104..2256 CDD:365869 39/209 (19%)
C8 2294..2362 CDD:214843 9/40 (23%)
TIL 2365..2426 CDD:366828
CT 2834..2916 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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