DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sls and Mag

DIOPT Version :9

Sequence 1:	NP_001261304.1	Gene:	sls / 44013	FlyBaseID:	FBgn0086906	Length:	18468	Species:	Drosophila melanogaster
Sequence 2:	NP_001333013.1	Gene:	Mag / 17136	MGIID:	96912	Length:	627	Species:	Mus musculus

Alignment Length:	544	Identity:	109/544 - (20%)
Similarity:	174/544 - (31%)	Gaps:	163/544 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QQHHGGSIGGAYVPPSLT---HVYAQGDIS-PPVFEQIFKNARFAQGGNALFEGRLRGNPKPFVT 119
            ::.:|..:|.....|:.|   ..||..|:. |||..::..:....:|.:.........||.|.:|
Mouse   208 REANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLT 272

  Fly   120 WTRKGAPLLESQKFRMSYNEATGDVSLLINQIGPGDEGEYTCTARNQYGEAICSVYIQPEGAPMP 184
            |.|.|..|.|:         ....:.|.:.::.||::|.|.|.|.|.||:...:|.:....||.
Mouse   273 WMRDGMVLREA---------VAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPW- 327

  Fly   185 ALQPIQNLEKNIYSNGYSYTSIEEEFRVDTFEYRLLREVSFREAITRRSGYEQDSQLSQELDRNQ 249
              :|..|
Mouse   328 --KPTVN---------------------------------------------------------- 332

  Fly   250 GPAQAPQISQKPRSSKLIEGSDAVFTARVGSNPKPRLTWFHNGQRLVASQKYEISYSSGVATLRV 314
            |...|            :||..........|||.|.||.|...| ::|:..||....     |.:
Mouse   333 GTVVA------------VEGETVSILCSTQSNPDPILTIFKEKQ-ILATVIYESQLQ-----LEL 379

  Fly   315 KNATARDGGHYTLLAENLQGCVVSSAVLAVEPAAETAYEPKPVDVMAEQLEAGKALPPAFVKAFG 379
            ...|..|.|.|..:|||..|...::..|:||.|        |:.::.....|.:......
Mouse   380 PAVTPEDDGEYWCVAENQYGQRATAFNLSVEFA--------PIILLESHCAAARDTVQCL----- 431

  Fly   380 DREITEGRMTRFDCRVTGNPYPEVFWLINGRQVRDDASHKILVNESGSHSLMITNVTRLDAGA-- 442
                         |.|..||.|.|.:.:..|.|..:.:.:..|....| .|::|::..:...|
Mouse   432 -------------CVVKSNPEPSVAFELPSRNVTVNETEREFVYSERS-GLLLTSILTIRGQAQA 482

  Fly   443 ---VQCLARNKAGEVAIEAQLNVLEK---------EQVVAPQF---VQRFSTMTVREGEPITMSA 492
               |.|.:||..|..::|.......:         ..|||...   :..:.|.| |..:.:|.|:
Mouse   483 PPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQT-RRKKNVTESS 546

  Fly   493 NAIGTPQPRITWQKDGVQISSTAERFVGIDGGATCLEIPRVTANDAGWYQCTAQNIAGSTANRAR 557
            :..|...|.:.:..: .:||...::                       |:...|.: ||......
Mouse   547 SFSGGDNPHVLYSPE-FRISGAPDK-----------------------YESEKQRL-GSERRLLG 586

  Fly   558 LYVEVPREQPNYEQRRLNLPRPTK 581
            |..|.|....:|....|. .||||
Mouse   587 LRGESPELDLSYSHSDLG-KRPTK 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sls	NP_001261304.1	I-set	87..174	CDD:254352	22/86 (26%)
		Ig	109..175	CDD:143165	19/65 (29%)
		Ig	254..334	CDD:299845	22/79 (28%)
		I-set	255..344	CDD:254352	23/88 (26%)
		I-set	372..462	CDD:254352	19/94 (20%)
		Ig	390..463	CDD:299845	19/77 (25%)
		Ig	471..561	CDD:299845	14/92 (15%)
		I-set	471..560	CDD:254352	14/91 (15%)
		I-set	618..709	CDD:254352
		Ig	645..705	CDD:143165
		DUF1136	715..741	CDD:284093
		IG_like	762..843	CDD:214653
		Ig	779..835	CDD:143165
		I-set	890..982	CDD:254352
		Ig	918..979	CDD:143165
		DUF1136	988..1014	CDD:284093
		I-set	1024..1116	CDD:254352
		Ig	1058..1113	CDD:143165
		I-set	1158..1250	CDD:254352
		Ig	1178..1246	CDD:143165
		DUF1136	1256..1282	CDD:284093
		I-set	1291..1380	CDD:254352
		IGc2	1304..1372	CDD:197706
		DUF1136	1388..1414	CDD:284093
		I-set	1424..1515	CDD:254352
		Ig	1442..1513	CDD:143165
		DUF1136	1522..1548	CDD:284093
		I-set	1558..1645	CDD:254352
		IGc2	1571..1639	CDD:197706
		DUF1136	1655..1679	CDD:284093
		I-set	1691..1782	CDD:254352
		IGc2	1718..1772	CDD:197706
		DUF1136	1788..1814	CDD:284093
		I-set	1824..1916	CDD:254352
		IGc2	1838..1906	CDD:197706
		DUF1136	1922..1948	CDD:284093
		I-set	1958..2049	CDD:254352
		Ig	1985..2044	CDD:143165
		I-set	2089..2181	CDD:254352
		IGc2	2103..2171	CDD:197706
		DUF1136	2187..2213	CDD:284093
		I-set	2222..2314	CDD:254352
		IGc2	2236..2304	CDD:197706
		DUF1136	2320..2346	CDD:284093
		I-set	2356..2448	CDD:254352
		Ig	2384..2445	CDD:143165
		DUF1136	2454..2480	CDD:284093
		I-set	2488..2580	CDD:254352
		Ig	2516..2576	CDD:143165
		I-set	2622..2714	CDD:254352
		IGc2	2636..2704	CDD:197706
		I-set	2754..2844	CDD:254352
		Ig	2771..2840	CDD:143165
		IGc2	2908..2974	CDD:197706
		I-set	3029..3120	CDD:254352
		Ig	3057..3116	CDD:143165
		I-set	3130..3220	CDD:254352
		Ig	3148..3219	CDD:143165
		I-set	3263..3354	CDD:254352
		I-set	3401..3493	CDD:254352
		Ig	3429..3490	CDD:143165
		I-set	3539..3630	CDD:254352
		Ig	3556..3625	CDD:143165
		I-set	3676..3767	CDD:254352
IGc2	3690..3758	CDD:197706
I-set	3811..3900	CDD:254352
Ig	3828..3899	CDD:143165
I-set	3954..4046	CDD:254352
Ig	3963..4042	CDD:299845
I-set	4092..4180	CDD:254352
Ig	4102..4172	CDD:299845
I-set	4394..4483	CDD:254352
Ig	4411..4480	CDD:143165
I-set	4497..4581	CDD:254352
Ig	4519..4580	CDD:143165
I-set	4604..4693	CDD:254352
Ig	4621..4691	CDD:299845
I-set	4702..4792	CDD:254352
Ig	4702..4791	CDD:299845
COG4372	4996..>5260	CDD:226809
I-set	6536..6622	CDD:254352
Ig	6554..6622	CDD:143165
Ig	6654..6725	CDD:143165
I-set	6743..6829	CDD:254352
Ig	6760..6829	CDD:299845
I-set	6841..6928	CDD:254352
Ig	6858..6927	CDD:143165
I-set	6942..7033	CDD:254352
IGc2	6957..7023	CDD:197706
I-set	7066..7157	CDD:254352
Ig	7084..7153	CDD:143165
IGc2	7224..7289	CDD:197706
Ehrlichia_rpt	14571..15030	CDD:118064
SH3_p47phox_like	16753..16807	CDD:212790
I-set	16841..16931	CDD:254352
Ig	16858..16931	CDD:299845
I-set	16965..17060	CDD:254352
IGc2	16978..17050	CDD:197706
I-set	17068..17152	CDD:254352
Ig_2	17078..17152	CDD:290606
IG_like	17170..17253	CDD:214653
Ig	17180..17250	CDD:143165
I-set	17260..17342	CDD:254352
IGc2	17274..17331	CDD:197706
I-set	17347..17432	CDD:254352
IGc2	17367..17423	CDD:197706
I-set	17437..17521	CDD:254352
Ig	<17468..17521	CDD:299845
I-set	17528..17611	CDD:254352
Ig	17553..17602	CDD:143165
I-set	17618..17708	CDD:254352
Ig	17635..17708	CDD:299845
FN3	17712..17791	CDD:238020
I-set	17813..17898	CDD:254352
Ig	17830..17894	CDD:143165
Ig	17922..17994	CDD:299845
FN3	17998..18090	CDD:238020
FN3	18098..18189	CDD:238020
FN3	18207..18298	CDD:238020
FN3	18307..18398	CDD:238020
Mag	NP_001333013.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		31/125 (25%)
		IgV_CD33	22..137	CDD:409377
		Ig strand B	38..42	CDD:409377
		Ig strand C	56..60	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	65..67
		Ig strand E	100..104	CDD:409377
		Ig strand F	114..119	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	124..128
		Ig strand G	128..133	CDD:409377
		IgC2_CD33_d2_like	141..235	CDD:409579	6/26 (23%)
		Ig strand B	155..159	CDD:409579
		Ig strand C	171..175	CDD:409579
		Ig strand E	200..204	CDD:409579
		Ig strand F	214..219	CDD:409579	1/4 (25%)
		Ig strand G	229..232	CDD:409579	0/2 (0%)
		Ig_3	239..309	CDD:404760	20/78 (26%)
		Ig strand A	239..242	CDD:409353	2/2 (100%)
		Ig strand A'	248..251	CDD:409353	0/2 (0%)
		Ig strand B	256..264	CDD:409353	0/7 (0%)
		Ig strand C	270..274	CDD:409353	1/3 (33%)
		Ig strand C'	277..280	CDD:409353	1/2 (50%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	4/7 (57%)
		Ig strand G	312..322	CDD:409353	2/9 (22%)
		IG	333..409	CDD:214652	25/93 (27%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000269\|PubMed:9482783	578..627		11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900