DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sls and Mylk

DIOPT Version :9

Sequence 1:NP_001261304.1 Gene:sls / 44013 FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_647461.3 Gene:Mylk / 107589 MGIID:894806 Length:1950 Species:Mus musculus


Alignment Length:1667 Identity:384/1667 - (23%)
Similarity:621/1667 - (37%) Gaps:355/1667 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly 16798 GWVPAQYLMEPEEYAQYVQNKLHEKIDKLPVFERPGPEDKPIAPRFIEKLQPIHTPDGYTVQFEC 16862
            |.:|.:.:.:.:.:|....:|....:|...|...|..|    ||.||...:.:...:|.|.:||.
Mouse     3 GQLPGKTMGDVKLFASSHMSKTSHSVDPSKVSSMPLTE----APAFILPPRNLCVKEGATAKFEG 63

  Fly 16863 KVEGNPRPQIAWFRETAIIKPSQDFQMFYDDDNVATLIIREVFPEDAGQFTVVAKNAAGFTSSTT 16927
            :|.|.|.||:.|.|:...|.....|.:........:|:|..|..||.|::|..|.|.:|....|.
Mouse    64 RVRGYPEPQVTWHRKGQAITNGGRFLLDCGVRGTFSLVIHTVREEDKGKYTCEASNGSGARQVTV 128

  Fly 16928 ELIVESPLSDHGSDATALSRRSMSRESSLADILEGIPPTFSKKPKAQYVDENTNVILECRLVAVP 16992
            ||.||.. |....|...||:.|.....:...|....||.|:.|.....|.|.......|::...|
Mouse   129 ELTVEGN-SMKKRDQPVLSKASGFPGETRPSIWGECPPKFATKLGRAVVKEGQMGRFSCKITGRP 192

  Fly 16993 EPDIVWTFNGEDIDEE-----------EIKNVRIVTESDMHMY-CSVVHISKVKKSQEGTYEVIA 17045
            .|.:.|......:...           :|..:|.||..|:.:| |.||:.|. |.|...  |:..
Mouse   193 PPQVTWLKGNVPLQPSARVSMSEKNGMQILEIRGVTRDDLGVYTCMVVNGSG-KASMSA--ELSI 254

  Fly 17046 TNREGEARLPITLKVRTTDKEAPQILEPLRNMVIREGESVV-----LSTQIVGN----------- 17094
            ...:..||    |.||.|...:|.|.:.:.|.|.::.|:|.     .|.|..|:           
Mouse   255 PGLDNAAR----LAVRGTKAPSPDIRKEVTNGVSKDPETVAESKNCPSPQRSGSSARATNSHLKS 315

  Fly 17095 ---PPPKVTWYKDGKPVKNAKSDKDLHTLTL----ITPQKSEKGEYTVKAVNPLGSVETTANLTI 17152
               |.||:......|..:::...|...|:||    :.|      |..|.|:......|...:|..
Mouse   316 PQEPKPKLCEDAPRKVPQSSILQKSTSTITLQALKVQP------EARVPAIGSFSPGEDRKSLAA 374

  Fly 17153 EEPA---------GGN-----------------AEPPLFVERFEEQNVPQKGEIRLPAKVSGNPV 17191
            .:.|         ||:                 :..|.|..:.:.|.|.:...::...:|||.|.
Mouse   375 PQQATLPTRQSSLGGSVGNKFVTGNIPRESQRESTFPRFESQPQSQEVTEGQTVKFICEVSGIPK 439

  Fly 17192 PEVQWLFNNTPLFPSERIQQVY-DGENIELIIKDANPETDSGDYKCIASNPIGKTSHGARVIVEV 17255
            |:|.|.....|:...|.|.:|| ||.:..|.:..|... |||.|.|.|||.:|:.|....::|:.
Mouse   440 PDVGWFLEGIPVRRREGITEVYEDGVSHHLCLLRARTR-DSGRYSCTASNSLGQVSCSWSLLVDR 503

  Fly 17256 DEV-----TFTKKLKKTITIEEVQSLTLECETSHVVTTK--WFFNGKELSGMDHRVVVEDGKTHK 17313
            ..:     :|:..||.::.||. |...|.|........:  |..||:.:. ..|.:.  :....:
Mouse   504 PNLAQTAPSFSSVLKDSVVIEG-QDFVLRCSVQGTPAPRVTWLLNGQPIQ-FAHSIC--EAGVAE 564

  Fly 17314 LVIRNTNLRDSGTYTCKVKKQETQ----STVEVLQRK------------------PDFIKVLEDY 17356
            |.|::....|.|||||..:....|    :||.|.::|                  |.|::.|.|.
Mouse   565 LHIQDALPEDRGTYTCLAENAMGQVSCSATVTVQEKKGEGEREHRLSPARSKPIAPIFLQGLSDL 629

  Fly 17357 EVTEKDTAILDVELT-TEATEVTWYKDGEKITPENKNVEFIKDGKARRLVIRDVTIHDEGQYTCK 17420
            :|.:.....:.|::: ....||.|..||.:| .|:::..|.:.|....|.|::|...|.|.|||:
Mouse   630 KVMDGSQVTMTVQVSGNPPPEVIWLHDGNEI-QESEDFHFEQKGGWHSLCIQEVFPEDTGTYTCE 693

  Fly 17421 I---EGQECSCELVVIELP-----PEIVEPLNDVAVTKGENAVFEVELSKGDAL--VKWFKNGK- 17474
            .   .|:..:..::.::.|     |..:.....|..|.|::.:....:: ||..  |.|.::|: 
Mouse   694 AWNSAGEVRTRAVLTVQEPHDGTQPWFISKPRSVTATLGQSVLISCAIA-GDPFPTVHWLRDGRA 757

  Fly 17475 --------EIVFNERIQLAIDGKKQSLRIVKAKPEDVGEYSVQVGEQTSKAKLTVEEPLVDFVIR 17531
                    |::.||.:        .:|.:...:|...|:|.:.:..:..:....|...|.:...|
Mouse   758 LSKDSGHFELLQNEDV--------FTLVLKNVQPWHAGQYEILLKNRVGECSCQVSLMLHNSPSR 814

  Fly 17532 LPDI---------------TLATKTTDAEFTVQLSQPDVEVTWCKKGKPIKPNQKHEVFVEGTVR 17581
            .|..               ..|....|...|::...|.....|        |.::....|.|.::
Mouse   815 APPRGREPASCEGLCGGGGVGAHGDGDRHGTLRPCWPARGQGW--------PEEEDGEDVRGLLK 871

  Fly 17582 RLV---IHDAS---DEDAGEI---SCVAENVTSSTKLCVEELKLPPVITSD---------KDQTI 17628
            |.|   :|...   .::.|::   ..:.:.|::.| :..::||..|....|         |.:||
Mouse   872 RRVETRLHTEEAIRQQEVGQLDFRDLLGKKVSTKT-VSEDDLKDIPAEQMDFRANLQRQVKPKTI 935

  Fly 17629 -----KVKENDDVTFTVKYTGVPTPEACWTTRKVVIP-KSKRTIPTIDEQSAKLTIKKVVDDDEG 17687
                 ||.....|.|........||       |..:| |:.....|.|.:|. |..||....:.|
Mouse   936 SEEERKVHSPQQVDFRSVLAKKGTP-------KTPVPEKAPPKAATPDFRSV-LGGKKKSPSENG 992

  Fly 17688 EYTVKLVN--------PVGEAEA--SLHLVIMRKPTAPGTPQPLEIMHDSITLYWKAPEDDGK-- 17740
            ..:.:::|        |.|:|:|  :|..|...||..  ||:|:.....:.||   .|..:.|  
Mouse   993 GNSAEVLNVKAGESPTPAGDAQAIGALKPVGNAKPAE--TPKPIGNAKPTETL---KPVGNTKPA 1052

  Fly 17741 -----------SEIIEYILEYQDVKEEKWTEIRKIKDTTYTISKLKIDTEYVFRSIAVNEVGPSP 17794
                       |..::.:...|..:.:|.....|..:|:....|.::.......:....:||.:.
Mouse  1053 ETLKPIANAQPSGSLKPVTNAQPAEPQKPVGNAKSAETSKPAGKEEVKEVKNDVNCKKGQVGATG 1117

  Fly 17795 PSPLSPPIRLVPKVETKAPSVQEPLQDV-VSELDKEVTLSCVFGGIPEPKVTWKKNGQVFESRS- 17857
            ....       |:.:..||..:|.|||| |:|.:| :.|.|.....|...|||..||:..::.. 
Mouse  1118 NEKR-------PESQGSAPVFKEKLQDVHVAEGEK-LLLQCQVISDPPATVTWSLNGKTLKTTKF 1174

  Fly 17858 --IRYENRVAKYTIEKTTIETEATYTCVATNEKGSAETSC---------------------RLKL 17899
              :..|......:|||...|....|.|||.|..|.||.||                     |.|.
Mouse  1175 IVLAQEGSRFSVSIEKALPEDRGLYKCVAKNSAGQAECSCQVTVDDAQTSENTKAPEMKSRRPKS 1239

  Fly 17900 QQKPVLEVEDKYLT------------------------QKLRTGSILTIPATVRGYPQPTVTWHK 17940
            ...|||..|.....                        ||:|.|..:.:...|.|....|..|.|
Mouse  1240 SLPPVLGTESDATVKKKPAPKTPTKAAMPPQIIQFPEDQKVRAGEPVELFGKVAGTQPITCKWMK 1304

  Fly 17941 ETIEQKTTKSVTIETTETTSTYTVKKVTREQSGKYKVTATNESGTTYVECTVQVIDKPSRPQSLE 18005
            ...:.:.::.:.:|..|:.|..|:....:|..|.|.:...|:.|:...:..:.|:|||..|....
Mouse  1305 FRKQIQESEHIKVENGESGSKLTILAARQEHCGCYTLVVENKLGSRQAQVNLTVVDKPDPPAGTP 1369

  Fly 18006 -IKDIKKDSIVLEWTPPVDDGGLDIEKYTLEKCDVQNNVWMKVSDFNKDIKSYAVQKLSMNAQYM 18069
             ..||:..|:.|.|.....|||..::.|.:|..|.::.||.:::....  .|:.||.|..:.:|.
Mouse  1370 CASDIRSSSLTLSWYGSSYDGGSAVQSYNVEIWDTEDKVWKELATCRS--TSFNVQDLLPDREYK 1432

  Fly 18070 FRVVAANPIGESEPTESDPVTITKKFEKPSPPRGPTTVSGMNDTSFNLAWEPSETDGGSKIIEYI 18134
            |||.|.|..|.|||::...:|...  |||..|:....||..::                      
Mouse  1433 FRVRAVNVYGTSEPSQESELTAVG--EKPEEPKDEVEVSDDDE---------------------- 1473

  Fly 18135 VEIREETETTYRSVGV-TLGTVTNIH-------------VEKVVRNK------GYFFRIYARNE- 18178
                :|.|..||:|.| |...|::::             |.::|..|      |.||:.|:..| 
Mouse  1474 ----KEPEVDYRTVTVNTEQKVSDVYDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEK 1534

  Fly 18179 ------------------VGTSEAFETTEKIVLGRKITNDNE 18202
                              |...:|||....||:..:|.:..|
Mouse  1535 DNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGE 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790 2/8 (25%)
I-set 16841..16931 CDD:254352 29/89 (33%)
Ig 16858..16931 CDD:299845 24/72 (33%)
I-set 16965..17060 CDD:254352 25/106 (24%)
IGc2 16978..17050 CDD:197706 18/83 (22%)
I-set 17068..17152 CDD:254352 23/106 (22%)
Ig_2 17078..17152 CDD:290606 20/96 (21%)
IG_like 17170..17253 CDD:214653 28/83 (34%)
Ig 17180..17250 CDD:143165 26/70 (37%)
I-set 17260..17342 CDD:254352 23/87 (26%)
IGc2 17274..17331 CDD:197706 15/58 (26%)
I-set 17347..17432 CDD:254352 24/88 (27%)
IGc2 17367..17423 CDD:197706 18/59 (31%)
I-set 17437..17521 CDD:254352 16/94 (17%)
Ig <17468..17521 CDD:299845 9/61 (15%)
I-set 17528..17611 CDD:254352 16/106 (15%)
Ig 17553..17602 CDD:143165 9/57 (16%)
I-set 17618..17708 CDD:254352 27/114 (24%)
Ig 17635..17708 CDD:299845 20/83 (24%)
FN3 17712..17791 CDD:238020 14/91 (15%)
I-set 17813..17898 CDD:254352 33/109 (30%)
Ig 17830..17894 CDD:143165 21/66 (32%)
Ig 17922..17994 CDD:299845 14/71 (20%)
FN3 17998..18090 CDD:238020 29/92 (32%)
FN3 18098..18189 CDD:238020 24/129 (19%)
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
MylkNP_647461.3 I-set 42..132 CDD:254352 29/89 (33%)
Ig 42..131 CDD:299845 28/88 (32%)
I-set 165..254 CDD:254352 22/91 (24%)
Ig 183..251 CDD:143165 16/70 (23%)
23ISL 255..409 CDD:293226 32/163 (20%)
I-set 411..501 CDD:254352 30/90 (33%)
Ig 428..498 CDD:143165 26/70 (37%)
I-set 511..597 CDD:254352 23/89 (26%)
IGc2 524..587 CDD:197706 16/66 (24%)
I-set 620..709 CDD:254352 24/89 (27%)
Ig 637..706 CDD:143165 19/69 (28%)
I-set 718..806 CDD:254352 17/96 (18%)
Ig 721..806 CDD:299845 16/93 (17%)
I-set 1129..1218 CDD:254352 32/89 (36%)
IGc2 1142..1208 CDD:197706 20/66 (30%)
Ig 1269..1366 CDD:299845 22/96 (23%)
I-set 1269..1358 CDD:254352 18/88 (20%)
FN3 1362..1453 CDD:238020 29/92 (32%)
STKc_MLCK1 1492..1750 CDD:271093 16/85 (19%)
Pkinase 1495..1750 CDD:278497 16/82 (20%)
I-set 1840..1930 CDD:254352
IGc2 1853..1920 CDD:197706
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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