DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pwn and frac

DIOPT Version :9

Sequence 1:	NP_610267.2	Gene:	pwn / 44011	FlyBaseID:	FBgn0003174	Length:	1363	Species:	Drosophila melanogaster
Sequence 2:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster

Alignment Length:	1218	Identity:	228/1218 - (18%)
Similarity:	351/1218 - (28%)	Gaps:	454/1218 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 YDSE-FSNEDANAQYIEVSDQDTDATGGEVEDELQPPPPPPSTTNNPPTTPTNPSKKKHKPKP-- 476
            ||.| :|:|.....|:|.||.|.|  ..|...|.:||||||     ||......|    ||:|
  Fly   128 YDLEDYSDETVPNDYVENSDIDED--DDEEVSEREPPPPPP-----PPVVDGADS----KPEPQI 181

  Fly   477 -----GSEKKKLPEESP---QDEGFSTIIET-----SSVVHTVMGMSSTYVPMSMDSSESLGLDP 528
                 .....::.|..|   :.|..:.::|.     :.|...|:..|:..|.::.|..|...||.
  Fly   182 VIEINDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDN 246

  Fly   529 STEE-----------VIFMTANRTP----------TLEPS-------VTSSLGTSSSSNPASAIQ 565
            :..|           :::...|: |          ||:|:       :...|.::...:......
  Fly   247 NCGEDNGGCAHICKRLLYPDENQ-PINKCDCREGYTLDPNDYASCLDIDECLESNGGCSEICENL 310

  Fly   566 PTSSK----------EHTKTTTTTTTTTS---SSTSTTTSTTTPPSTESVSPNSSNANTNATPPA 617
            |...|          |..|:........:   ||.........|.|...|.|...|.........
  Fly   311 PGEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVEN 375

  Fly   618 PYHPRPGIVLDDPEFKPGGRPRPPVQRPPAQQTLPLPAVQPTRQHLPPGYGEIFDVTLSAIQGPG 682
            |......:.::..|.:|.|:......:..|..|                  :..|:....:.||.
  Fly   376 PIEKTNEVPVNVSESQPAGKTCNSGFQLSADGT------------------DCQDINECEVDGPE 422

  Fly   683 PKGSGS------QQTINIKPYGSYAAGGGQGDIIVSASGDDGFVSIDGKRTYINLFGDPTDPPAG 741
            ...:.:      :.||     ||:.....:|..::.          |.:...::...|..:|...
  Fly   423 DLDNNAVCQQKCENTI-----GSFRCTCVEGYHLLE----------DQRSCALDSCTDLENPQLN 472

  Fly   742 ATTPATRLPQLPGSGSGS---------------------GSGSGTGSG-GASTPGVGVSSGGGGG 784
            .|..|.....||   .||                     .|...|..| ...:||..::|    .
  Fly   473 RTRCAHECQDLP---EGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLAS----E 530

  Fly   785 SGSSISPAAP-----------------------ANAVTQSSGGYVVPETEVVDL----------- 815
            ..:|.|...|                       ::....:.|||.....|.::|
  Fly   531 DNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENL 595

  Fly   816 ---------QGHSKPQGGAPTTNAGPTRPHYRQRPTQPPVR-IDTCIVG---------------- 854
                     |.....:||......|     :|......... :|.|:|.
  Fly   596 CEVNNNGCEQICLTARGGVCACREG-----FRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYG 655

  Fly   855 --------------------DDSTCDQAQH-----ERCKTDNGVSSCHCRPGYSRRKHREPCRRV 894
                                |...|.|..|     ..|:..||..:|.|.|||:
  Fly   656 CICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYA----------- 709

  Fly   895 ISFHLGMRVDRIYEHRIVWDTKLMDKHSEPFGQLSYESIRALDSAMSMTPYS------DEFMEAK 953
                ||:      ::.||               .|..|....||..|.||.:      ||...|.
  Fly   710 ----LGL------DNHIV---------------TSLNSSFITDSTSSETPSAHTCLDIDECSLAN 749

  Fly   954 VN--NIYRGDPNLGGSGVYVNMTIKLDESVETLRPNLRSDVQKHLLGVLHRRNNNIGNSVLYVSS 1016
            .|  :..:.:|  ||......:...|.|.:.|.:     |:.:.|       ::|...|.|.::.
  Fly   750 GNCSHFCQNEP--GGFQCACPLGYALSEDMRTCQ-----DIDECL-------DSNGQCSQLCLNQ 800

  Fly  1017 PEGAVSALQ-------------DLDECQSPELNDC----------HSGA---------------- 1042
            |.|...|.:             |:||| |.:..:|          |:.|
  Fly   801 PGGFACACETGFELTPDGFGCADIDEC-SQDYGNCSDICINLLGTHACACERGYELAKDKLSCLD 864

  Fly  1043 --------------SCSNTWGSFRCACEAG--LRDPWAD-QPARSG------RECQACADSVCN- 1083
                          .|.|..|:|.|.|..|  |.|.... .||..|      |....||...||
  Fly   865 VDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNP 929

  Fly  1084 ------------------NHGTCSYA---EDGAQLCTC------DSSHYGAQ----CEIDGEVLG 1117
                              .:|.||:.   .:|:..|:|      ||.....|    |:.|.
  Fly   930 GYTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDK---- 990

  Fly  1118 VAIGASVAAIIIIVLTLVCLIMWSRRWQREQKNAMGS-----PVFGYMNTAPLKSAGLPQAGYQV 1177
                       ...:|..|:            |.:|.     |.|..:...|..|: ||::.
  Fly   991 -----------TSCITGTCI------------NEIGGFRCEFPKFPVLPEIPTASS-LPESP--- 1028

  Fly  1178 TLEDRMRWAQIADVMAQTNHYGAEPIGPTRPSSAMFAYPNLGAMGMGTLGGMSLQSTMQMHPSA- 1241
              :..::..:..|....:|..   |..|.:|  |.|.||......:....|:.     ::.|.|
  Fly  1029 --KIELKTPKYPDFTELSNEI---PENPKKP--AEFDYPEPKFPSLPKWEGLP-----KLPPLAD 1081

  Fly  1242 --TLAPPVPL-PRLGLGPRSNGMRTLENSSSSEEEDRADLLGRNFQVPR-PKSRSNGSIANQSGI 1302
              |...|||| |.:   |:|..:..|:         ..||..| ||.|| .||..|.....|...
  Fly  1082 IPTSKAPVPLRPEV---PKSLWVNQLQ---------PRDLCPR-FQAPRNGKSHCNRYRHKQKLF 1133

  Fly  1303 YY-------DVDYEPSGNGIGNSSVDHLY-GSQNQSVTHSSGHSHIPG 1342
            ||       :..|...|..|.:...:.:: |.:.:.|..:...:..||
  Fly  1134 YYSRCRISCNSGYILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPG 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pwn	NP_610267.2	EGF_CA	1026..1075	CDD:214542	21/97 (22%)
		EGF_2	1074..1109	CDD:285248	13/66 (20%)
		Abhydrolase_9_N	<1124..>1165	CDD:292062	6/45 (13%)
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	5/34 (15%)
		cEGF	396..415	CDD:289433	3/36 (8%)
		FXa_inhibition	425..458	CDD:291342	6/47 (13%)
		FXa_inhibition	476..505	CDD:291342	5/31 (16%)
		vWFA	<550..586	CDD:294047	5/35 (14%)
		FXa_inhibition	596..630	CDD:291342	5/38 (13%)
		FXa_inhibition	636..>664	CDD:291342	2/27 (7%)
		EGF_CA	676..715	CDD:284955	14/59 (24%)
		FXa_inhibition	745..780	CDD:291342	7/36 (19%)
		FXa_inhibition	786..821	CDD:291342	7/41 (17%)
		FXa_inhibition	827..862	CDD:291342	5/35 (14%)
		FXa_inhibition	874..904	CDD:291342	9/29 (31%)
		FXa_inhibition	945..980	CDD:291342	8/34 (24%)
		CCP	1110..1170	CDD:153056	15/60 (25%)
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24034
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100