Protein Alignment pwn and pwn

DIOPT Version :10

• Sequence 1: NP_610267.2
• Gene: pwn / 44011
• FlyBaseID: FBgn0003174
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: XP_061502063.1
• Gene: pwn / 1269612
• VectorBaseID: AGAMI1_013205
• Length: 1332
• Species: Anopheles gambiae
• Alignment Length: 1464
• Identity: 671/1464 - (45%)
• Similarity: 805/1464 - (54%)
• Gaps: 303/1464 - (20%)

  Fly    46 HRHLMAMVVSTLPLALLLLLVQTTAGQHESVSQISPKSSSHRSPDRQRIESTMADSVNGLAEGQS 110
            :|.:.||:|     .|.|..|.|||      |....:|.|..||.    :.|...:.:.||....
Mosquito    23 YRLIAAMLV-----GLCLSAVATTA------STFPKQSPSCNSPQ----DCTTTATTDALAGKSK 72

  Fly   111 SPLDVNDNETRAERVERSASPILHDRQPIGPNDVHFPEDLEKDVSAGRYFHYNIKPTGTFDNQDE 175
            ....:|:...|:...:||...:..|.   ..|.|     ||....:||    |.|     |..||
Mosquito    73 RSAIMNELTPRSASGDRSLLAVSFDS---NSNSV-----LEATGPSGR----NGK-----DLLDE 120

  Fly   176 QPERTHQGIRAGKTLSQGGSSSEQSFLGRGDLRPLVSGSPIRPSPSNTATSATAASATQAPHSPR 240
            ..:||       |.|:...|:.:::.|.....||.|...| .|:|..:..|             |
Mosquito   121 SYQRT-------KELAMNISNVQRAVLASQQNRPPVFRVP-GPAPPQSQGS-------------R 164

  Fly   241 QNGNPDIQDIITGIVKLLNGNVNVHANTQGIRRPSASRINNRGPPRISEAQNLPIDYEAQKPG-T 304
            ||.||||||||||||||||||||||||.|..||.|||||||||||||||||.||.:||.:... |
Mosquito   165 QNPNPDIQDIITGIVKLLNGNVNVHANPQPTRRHSASRINNRGPPRISEAQPLPNEYEGELGAPT 229

  Fly   305 SMRP--------------PPYPFDRPE----RPFITGVPIPEQIVP-----VRPGFVS-NRPPWY 345
            |.||              ||....||:    |||:|||||||||||     .|||||| |||||.
Mosquito   230 SSRPLLQPDQQGQQQPSGPPQSGPRPDGHPIRPFLTGVPIPEQIVPSMQQTYRPGFVSQNRPPWQ 294

  Fly   346 RNKPRPPIATSVGGNRRPLPQYKPLPAP------------PVQAPLQPQ--DPLDRKNEQEKEQN 396
            |.||||||:.    ||||:|.|||.|..            |:..|....  :.:|...|:..|..
Mosquito   295 RPKPRPPISP----NRRPIPPYKPYPTSLDYRPDSGPNTGPIAIPTNNDGGNAIDNVTEKVIEDP 355

  Fly   397 HQEQP------QPTDDVVLPTDTTYDSEFSNEDANAQYIEVSDQDTDATGGEVEDELQPPPPPPS 455
            ..|.|      .||        ||........|...:|  .:...|..|..| .|:.||...||.
Mosquito   356 PYEAPTSGGGNYPT--------TTQQGNTGEVDPEQEY--TTTTSTSTTTSE-SDQQQPITGPPK 409

  Fly   456 TTNNPPTTPTNPSKKKHKPKPG-SEKKKLPEESPQDEGFSTIIETSSVVHTVMGMSS-TYVPMSM 518
            ..:.|..||  |::.::..:.. |....:|...|..|     :....||.:|..::| .|:|
Mosquito   410 RKSTPKPTP--PTEVQYTIESATSAASVMPATGPNGE-----VYDPEVVPSVFEINSIEYLP--- 464

  Fly   519 DSSESLGLDPSTEEVIFMTANRTPTLEPSVTSSLGTSSSSNPASAIQPTS----SKEHTKTTTTT 579
             ||..|...|||.:.|..|:: |..:||        |:..:.:..|.||.    :.|..||||||
Mosquito   465 -SSGVLEPTPSTTDGIIATSS-TAGIEP--------SNGGDHSPTITPTPTLVLTSETIKTTTTT 519

  Fly   580 TTTTSSSTSTTTSTT-TPPSTES--VSPNSSNANTNATPPAPYHPRPGIVLDDPEFKPGG----- 636
            ||||:::|:||||.. .|.||.|  ::|:.::.....|....:.||||:|||||:|||||
Mosquito   520 TTTTTTTTTTTTSPAGLPHSTTSDVIAPSKASPEPAKTSDYRFQPRPGLVLDDPDFKPGGGAAAA 584

  Fly   637 ----------RPRPPVQRPPAQQTLPLPAV---QPTRQHLPPGYGEIFDVTLSAIQGPGPKGSGS 688
                      :..||....|...|.|.|..   .|..:  ||.||||||||||||||||..||||
Mosquito   585 GPGNSNAIRTQNLPPFANRPEIYTAPPPGAGSGAPGGR--PPNYGEIFDVTLSAIQGPGSGGSGS 647

  Fly   689 QQTINIKPY------GSYAAG--GGQGDIIVSASGDDGFVSIDGKRTYINLFGDPTD-----PPA 740
            ||||.|.||      |..|.|  ||:..||::.:|.||||||||||:||:|||..|.     .|.
Mosquito   648 QQTIKINPYYNRGQPGGGAGGGPGGEASIILTGTGTDGFVSIDGKRSYIDLFGTETQRKTQIQPT 712

  Fly   741 GATTP-----ATRLPQLPGSGSGSGSGSGTGSGGASTPGVGVSSGGGGGSGSSISPAAPANAVTQ 800
             ||.|     ||..|:.|                                  .|.|..||.....
Mosquito   713 -ATRPVGPIAATERPKPP----------------------------------KIGPTPPALQPGI 742

  Fly   801 SSGGYVVPETE----VVDLQGHSKPQGG----------APTTNAGPTRPHYRQRPTQPPVRIDTC 851
            ...||.|||||    ...:..:.||..|          ||:.:  .:||.|......||||||||
Mosquito   743 IGTGYAVPETESPVHAGPIGSNQKPPSGGGAAGGSVHRAPSVH--QSRPKYPGAIGLPPVRIDTC 805

  Fly   852 IVGDDSTCDQAQHERCKTDNGVSSCHCRPGYSRRKHREPCRRVISFHLGMRVDRIYEHRIVWDTK 916
            ||||||||||||:|||||:||||||||||||:||||||||||::|..|.||||:|||.||.||..
Mosquito   806 IVGDDSTCDQAQNERCKTENGVSSCHCRPGYARRKHREPCRRIVSLALSMRVDKIYERRIHWDVS 870

  Fly   917 LMDKHSEPFGQLSYESIRALDSAMSMTPYSDEFMEAKVNNIYRGDPNLGGS-------GVYVNMT 974
            |.|:.||.:.|||||:|||:||||||||:||||:||::|.||..:|:.|.:       .|:||.|
Mosquito   871 LADRSSEKYQQLSYEAIRAMDSAMSMTPFSDEFLEARINGIYTVNPSSGSAASGASSGAVFVNYT 935

  Fly   975 IKLDESVETLRPNLRSDVQKHLLGVLHRRNNNIGNSVLYVSSPEGAVSALQDLDECQSPELNDCH 1039
            :.|||:.|||||.||||:|:|||||:||||||||||.|||.:|.||||::||:|||.|.|||||.
Mosquito   936 VNLDENAETLRPALRSDIQRHLLGVIHRRNNNIGNSALYVEAPTGAVSSVQDVDECTSDELNDCD 1000

  Fly  1040 SGASCSNTWGSFRCACEAGLRDPWADQPARSGRECQACADSVCNNHGTCSYAEDGA---QLCTCD 1101
            ..|.|:|.:|:|||.|..|.||||||||.|:||||.:|.:|.|.|.|||||  |.|   |:|.|.
Mosquito  1001 EEAHCTNLFGTFRCECNVGFRDPWADQPQRAGRECLSCPESYCTNRGTCSY--DNANNRQVCKCL 1063

  Fly  1102 SSHYGAQCEIDGEVLGVAIGASVAAIIIIVLTLVCLIMWSRRWQREQKNAMGSPVFGYMNTAPLK 1166
            .|:||.||||||||||||:||||||:|||||||:||:||||:||||.|||||||||||:....:|
Mosquito  1064 GSYYGTQCEIDGEVLGVAVGASVAAVIIIVLTLICLVMWSRKWQREHKNAMGSPVFGYLGNGQVK 1128

  Fly  1167 SAGLPQAGYQVTLEDRMRWAQIADVMAQTNHYG-----AEPIGPTRPSSAMFAYPNLGAMG-MGT 1225
            :..:.||.||||||||||||||||||||.|||.     |||:. .||||||:.||||..:| |.|
Mosquito  1129 TPVMGQAPYQVTLEDRMRWAQIADVMAQANHYAVSYIDAEPVA-GRPSSAMYGYPNLQTIGSMNT 1192

  Fly  1226 LGGMSLQSTMQMHPSATLAPPVPLPRLGLGPRSNGMRTLENSSSSEEEDRADLLGRNFQVPRPKS 1290
            |   ||..|:.|| :.|| |||||||. ||...|||||||||||||||||||||||||.||||||
Mosquito  1193 L---SLHGTLPMH-TGTL-PPVPLPRT-LGLNRNGMRTLENSSSSEEEDRADLLGRNFNVPRPKS 1251

  Fly  1291 RSNGSIANQSGIYYDVDYEPSGNGIGNSSVDHLYGSQNQSVTHSSGHSHIPGPQG---------- 1345
            |||.|:.  |||||||||.|:|       .:.|||          |.|.:.|..|
Mosquito  1252 RSNASVT--SGIYYDVDYAPTG-------AEQLYG----------GGSTLGGTIGLGGQMGGGGV 1297

  Fly  1346 ----------------IPMSTYTSGRAP--SSYY 1361
                            ||||||||...|  |:||
Mosquito  1298 GGGGMGAGGTTKSQSSIPMSTYTSSGRPLQSTYY 1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pwn	NP_610267.2	PHA03247	<273..413	CDD:223021	80/184 (43%)
		EGF_CA	1026..1075	CDD:214542	31/48 (65%)
		EGF_2	1081..1109	CDD:400365	15/30 (50%)
pwn	XP_061502063.1	None