DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm1 and PGM2

DIOPT Version :9

Sequence 1:	NP_524675.1	Gene:	Pgm1 / 44010	FlyBaseID:	FBgn0003076	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_013823.1	Gene:	PGM2 / 855131	SGDID:	S000004711	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	574	Identity:	273/574 - (47%)
Similarity:	375/574 - (65%)	Gaps:	19/574 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLTVEIVATKPYEGQKPGTSGLRKKVKVF-TQPNYTENFVQAILEANGAALAGSTLVVGGDGRF 64
            ||..:|.|.|||||.|||||||||||.||| .:|||||||:|:|:||......|:|||||||||:
Yeast     1 MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSIMEAIPEGSKGATLVVGGDGRY 65

  Fly    65 YCKEAAELIVRLSAANGVSKLLVGQNGILSTPAVSSLIR--HNKALGGIVLTASHNPGGPENDFG 127
            |.......|..:.||||:.||::||:|:|||||.|.::|  ..|..|||:|||||||||||||.|
Yeast    66 YNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHIMRTYEEKCTGGIILTASHNPGGPENDMG 130

  Fly   128 IKFNCENGGPAPDAFTNHIYKITTEIKEYKLVRNL-QIDISKVGVTSFDIAGKPFTVEVIDSVAN 191
            ||:|..||||||::.||.|::|:.::..||::::. ::|:..:|...   ...|..|::||...:
Yeast   131 IKYNLSNGGPAPESVTNAIWEISKKLTSYKIIKDFPELDLGTIGKNK---KYGPLLVDIIDITKD 192

  Fly   192 YVRHMEEIFDFAKLKDFVSGKATGKPLKMRIDAMNGVTGSYVREIFLNRLGATESSVVHT-TPLP 255
            ||..::|||||..:|.|:..:.:.|..|:..|:||||||.|.:.||::..|.....|:.. .|.|
Yeast   193 YVNFLKEIFDFDLIKKFIDNQRSTKNWKLLFDSMNGVTGPYGKAIFVDEFGLPADEVLQNWHPSP 257

  Fly   256 DFGGLHPDPNLTYAKDLVDTVAQGDYDIGAAFDGDGDRNMIIGSKAFFVTPSDSLAVIAHYLEAI 320
            ||||:|||||||||..||..|.:...:.|||.|||||||||.|....||:|.||:|:||.|...|
Yeast   258 DFGGMHPDPNLTYASSLVKRVDREKIEFGAASDGDGDRNMIYGYGPSFVSPGDSVAIIAEYAAEI 322

  Fly   321 PYFQKNGVQGFARSMPTASAVDLVGRKLGKEVFEVPTGWKYFGNLMDAGRLCLCGEESFGTGSNH 385
            |||.|.|:.|.|||.||:.|:|.|.:..|...:|||||||:|..|.||.:|.:||||||||||||
Yeast   323 PYFAKQGIYGLARSFPTSGAIDRVAKAHGLNCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNH 387

  Fly   386 IREKDGIWAVLAWISVMQHTGK-------GIEDILKQHWSVYGRNYFTRYDYEECASDPCNEMVA 443
            :|||||:||::||::::....|       .|:.|..:.|:.|||.:|||||:|:..::..|::|.
Yeast   388 VREKDGVWAIMAWLNILAIYNKHHPENEASIKTIQNEFWAKYGRTFFTRYDFEKVETEKANKIVD 452

  Fly   444 TMEKTITAPEFVGKSYSSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLSGTG 508
            .:...:|....|..::.: .::.||.:..:||||| :|.||:..|||.:...:|:|.|:||||||
Yeast   453 QLRAYVTKSGVVNSAFPA-DESLKVTDCGDFSYTD-LDGSVSDHQGLYVKLSNGARFVLRLSGTG 515

  Fly   509 SSGATVRLYIDSY--EKENVLGQASVMLKPLIDIALEISQLPKFTGRNAPTVIT 560
            |||||:||||:.|  :|......|...|||:|:..::.....:..|...|||.|
Yeast   516 SSGATIRLYIEKYCDDKSQYQKTAEEYLKPIINSVIKFLNFKQVLGTEEPTVRT 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm1	NP_524675.1	PLN02307	1..560	CDD:177942	272/572 (48%)
Pgm1	NP_524675.1	PGM1	6..560	CDD:100087	270/567 (48%)
PGM2	NP_013823.1	PGM1	6..569	CDD:100087	270/567 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346750
Domainoid	1	1.000	175	1.000	Domainoid score	I737
eggNOG	1	0.900	-	-		E1_COG0033
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1979
Inparanoid	1	1.050	532	1.000	Inparanoid score	I183
Isobase	1	0.950	-	0	Normalized mean entropy	S456
OMA	1	1.010	-	-		QHG54024
OrthoFinder	1	1.000	-	-		FOG0001684
OrthoInspector	1	1.000	-	-		otm46582
orthoMCL	1	0.900	-	-		OOG6_100937
Panther	1	1.100	-	-	O	PTHR22573
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R914
SonicParanoid	1	1.000	-	-		X1241
TreeFam	1	0.960	-	-
	16	15.740