DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm1 and PGM1

DIOPT Version :9

Sequence 1:	NP_524675.1	Gene:	Pgm1 / 44010	FlyBaseID:	FBgn0003076	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_012795.1	Gene:	PGM1 / 853732	SGDID:	S000001610	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	577	Identity:	276/577 - (47%)
Similarity:	381/577 - (66%)	Gaps:	24/577 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLTVEIVATKPYEGQKPGTSGLRKKVKVF-TQPNYTENFVQAILEA--NGAALAGSTLVVGGDG 62
            |||.::.|.|..|:.|||||||||||.||| .:|:|||||:||.:::  ||:  .|:||||||||
Yeast     1 MSLLIDSVPTVAYKDQKPGTSGLRKKTKVFMDEPHYTENFIQATMQSIPNGS--EGTTLVVGGDG 63

  Fly    63 RFYCKEAAELIVRLSAANGVSKLLVGQNGILSTPAVSSLIR--HNKAL-GGIVLTASHNPGGPEN 124
            |||.......|..:.|||||.||::||.|:|||||.|.:||  ..|.. |||:||||||||||||
Yeast    64 RFYNDVIMNKIAAVGAANGVRKLVIGQGGLLSTPAASHIIRTYEEKCTGGGIILTASHNPGGPEN 128

  Fly   125 DFGIKFNCENGGPAPDAFTNHIYKITTEIKEYKLVRNL-QIDISKVGVTSFDIAGKPFTVEVIDS 188
            |.|||:|..||||||::.||.|::.:.::..||:::|. :::::|:|...   ...|..|::||.
Yeast   129 DLGIKYNLPNGGPAPESVTNAIWEASKKLTHYKIIKNFPKLNLNKLGKNQ---KYGPLLVDIIDP 190

  Fly   189 VANYVRHMEEIFDFAKLKDFVSGKATGKPLKMRIDAMNGVTGSYVREIFLNRLGATESSVVHT-T 252
            ...||:.::|||||..:|.|::.:...|..|:..|::||:||.|.:.||::..|.....|:.. .
Yeast   191 AKAYVQFLKEIFDFDLIKSFLAKQRKDKGWKLLFDSLNGITGPYGKAIFVDEFGLPAEEVLQNWH 255

  Fly   253 PLPDFGGLHPDPNLTYAKDLVDTVAQGDYDIGAAFDGDGDRNMIIGSKAFFVTPSDSLAVIAHYL 317
            |||||||||||||||||:.|||.|.:.....|||.|||||||||.|....||:|.||:|:||.|.
Yeast   256 PLPDFGGLHPDPNLTYARTLVDRVDREKIAFGAASDGDGDRNMIYGYGPAFVSPGDSVAIIAEYA 320

  Fly   318 EAIPYFQKNGVQGFARSMPTASAVDLVGRKLGKEVFEVPTGWKYFGNLMDAGRLCLCGEESFGTG 382
            ..||||.|.|:.|.|||.||:||:|.|..|.|...:|||||||:|..|.||.:|.:|||||||||
Yeast   321 PEIPYFAKQGIYGLARSFPTSSAIDRVAAKKGLRCYEVPTGWKFFCALFDAKKLSICGEESFGTG 385

  Fly   383 SNHIREKDGIWAVLAWISVM-------QHTGKGIEDILKQHWSVYGRNYFTRYDYEECASDPCNE 440
            |||||||||:||::||::::       ......|:.|..:.|:.|||.:|||||||....:...:
Yeast   386 SNHIREKDGLWAIIAWLNILAIYHRRNPEKEASIKTIQDEFWNEYGRTFFTRYDYEHIECEQAEK 450

  Fly   441 MVATMEKTITAPEFVGKSYSSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLS 505
            :||.:.:.::.|...| |:....::..|.:..:|||.| :|.|::..|||.:.|.:|::.|:|||
Yeast   451 VVALLSEFVSRPNVCG-SHFPADESLTVIDCGDFSYRD-LDGSISENQGLFVKFSNGTKFVLRLS 513

  Fly   506 GTGSSGATVRLYIDSY--EKENVLGQASVMLKPLIDIALEISQLPKFTGRNAPTVIT 560
            ||||||||:|||::.|  :|||....|.|.|||:|:..::..:..:..|.:.|||.|
Yeast   514 GTGSSGATIRLYVEKYTDKKENYGQTADVFLKPVINSIVKFLRFKEILGTDEPTVRT 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm1	NP_524675.1	PLN02307	1..560	CDD:177942	275/575 (48%)
Pgm1	NP_524675.1	PGM1	6..560	CDD:100087	272/570 (48%)
PGM1	NP_012795.1	phosphohexomutase	8..570	CDD:422966	272/568 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346751
Domainoid	1	1.000	175	1.000	Domainoid score	I737
eggNOG	1	0.900	-	-		E1_COG0033
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1979
Inparanoid	1	1.050	532	1.000	Inparanoid score	I183
Isobase	1	0.950	-	0	Normalized mean entropy	S456
OMA	1	1.010	-	-		QHG54024
OrthoFinder	1	1.000	-	-		FOG0001684
OrthoInspector	1	1.000	-	-		otm46582
orthoMCL	1	0.900	-	-		OOG6_100937
Panther	1	1.100	-	-	LDO	PTHR22573
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1241
TreeFam	1	0.960	-	-
	15	14.710