DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm1 and Pgm5

DIOPT Version :9

Sequence 1:	NP_524675.1	Gene:	Pgm1 / 44010	FlyBaseID:	FBgn0003076	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001178882.1	Gene:	Pgm5 / 679990	RGDID:	1307969	Length:	567	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	278/566 - (49%)
Similarity:	391/566 - (69%)	Gaps:	12/566 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTVEIVATKPYEGQKP-GTSGLRKKVKVFT-QPNYTENFVQAILEA-NGAALAGSTLVVGGDGRF 64
            :.|..|.|.|||.|:| |..|||:...:|. |.||..||:|::|.: :.....|.|:|||.|||:
  Rat     6 IPVLTVPTAPYEDQRPTGGGGLRRPTGLFEGQRNYLPNFIQSVLSSIDLRDRQGCTMVVGSDGRY 70

  Fly    65 YCKEAAELIVRLSAANGVSKLLVGQNGILSTPAVSSLIRHNKALGGIVLTASHNPGGPENDFGIK 129
            :.:.|.|::|:::||||:.:|::||||||||||||.:||..||.|||:|||||.||||..:||:|
  Rat    71 FSRTATEIVVQMAAANGIGRLIIGQNGILSTPAVSCIIRKIKAAGGIILTASHCPGGPGGEFGVK 135

  Fly   130 FNCENGGPAPDAFTNHIYKITTEIKEYKLVRNLQIDISKVGVTSFDIAG--KPFTVEVIDSVANY 192
            ||..|||||||..::.||:|:..|:||.:..:|:||:|::|...||:..  |||.||::|.|..|
  Rat   136 FNVANGGPAPDVVSDKIYQISKTIEEYTICPDLRIDLSRLGRQEFDLENKFKPFRVEIVDPVDIY 200

  Fly   193 VRHMEEIFDFAKLKDFVSGKATGKPLKMRIDAMNGVTGSYVREIFLNRLGATESSVVHTTPLPDF 257
            :..:..||||..:|..::|.:   .||:|:|||:||.|.|||::..:.|||..:|.::..||.||
  Rat   201 LNLLRTIFDFNAIKSLLTGPS---QLKIRVDAMHGVMGPYVRKVLCDELGAPANSAINCVPLEDF 262

  Fly   258 GGLHPDPNLTYAKDLVDTVAQGDYDIGAAFDGDGDRNMIIGSKAFFVTPSDSLAVIAHYLEAIPY 322
            ||.|||||||||..|::.:..|:|..|||||.||||.||:|...|||:||||||:||..|..|||
  Rat   263 GGQHPDPNLTYATTLLEAMKGGEYGFGAAFDADGDRYMILGQNGFFVSPSDSLAIIAANLSCIPY 327

  Fly   323 FQKNGVQGFARSMPTASAVDLVGRKLGKEVFEVPTGWKYFGNLMDAGRLCLCGEESFGTGSNHIR 387
            |::.||:||.|||||:.|:|.|.:.:...|:|.|.||::|.||||:||..|||||||||||:|:|
  Rat   328 FRQMGVRGFGRSMPTSMALDRVAKSMKVPVYETPAGWRFFSNLMDSGRCSLCGEESFGTGSDHLR 392

  Fly   388 EKDGIWAVLAWISVMQHTGKGIEDILKQHWSVYGRNYFTRYDYEECASDPCNEMVATMEKTITAP 452
            ||||:||||.|:|::....:.:|:|::.||:.|||:|:.|:|||.........::..:|..:|..
  Rat   393 EKDGLWAVLVWLSIIAARKQSVEEIVRDHWAKYGRHYYCRFDYEGLEPKATYYIMRDLEALVTDK 457

  Fly   453 EFVGKSYSSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLSGTGSSGATVRLY 517
            .|:|:.::.|...|.:.:.|:|.|.||||.:|..||||||:|.|.||::.|||.:....||:|||
  Rat   458 SFIGQQFAVGSHIYSIAKTDSFEYVDPVDGTVTKKQGLRIIFSDASRLIFRLSSSSGVRATIRLY 522

  Fly   518 IDSYEKENVLG---QASVMLKPLIDIALEISQLPKFTGRNAPTVIT 560
            .:|||:: ..|   :...:|.|||.|||:|||:.:.|||..|||||
  Rat   523 AESYERD-PSGHDQEPQAVLSPLIAIALKISQIHERTGRRGPTVIT 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm1	NP_524675.1	PLN02307	1..560	CDD:177942	276/564 (49%)
Pgm1	NP_524675.1	PGM1	6..560	CDD:100087	275/561 (49%)
Pgm5	NP_001178882.1	phosphohexomutase	10..567	CDD:422966	275/560 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335268
Domainoid	1	1.000	188	1.000	Domainoid score	I3222
eggNOG	1	0.900	-	-		E1_COG0033
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	661	1.000	Inparanoid score	I729
OMA	1	1.010	-	-		QHG54024
OrthoDB	1	1.010	-	-		D175278at33208
OrthoFinder	1	1.000	-	-		FOG0001684
OrthoInspector	1	1.000	-	-		otm44714
orthoMCL	1	0.900	-	-		OOG6_100937
Panther	1	1.100	-	-	O	PTHR22573
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1241
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770