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Protein Alignment Pgm1 and PGM2

DIOPT Version :9

Sequence 1:	NP_524675.1	Gene:	Pgm1 / 44010	FlyBaseID:	FBgn0003076	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_060760.2	Gene:	PGM2 / 55276	HGNCID:	8906	Length:	612	Species:	Homo sapiens

Alignment Length:	589	Identity:	138/589 - (23%)
Similarity:	222/589 - (37%)	Gaps:	138/589 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLTVEIVATKPYEGQKP------------GTSGLR-------KKVKVFTQPNYTENFVQAILEAN 47
            |||:|.|.....||.|.            ||:|||       .::...|....|:.|.: .||..
Human    29 SLTLEAVKRLIAEGNKEELRKCFGARMEFGTAGLRAAMGPGISRMNDLTIIQTTQGFCR-YLEKQ 92

  Fly    48 GAALAGSTLVV----------GGDGRFYCKEAAELIVRLSAANGVSKLLVGQNGILSTPAVSSLI 102
            .:.|....:|:          ||..|.:.:.||...:    :.|:...|.  :.|..||.|...:
Human    93 FSDLKQKGIVISFDARAHPSSGGSSRRFARLAATTFI----SQGIPVYLF--SDITPTPFVPFTV 151

  Fly   103 RHNKALGGIVLTASHNPGGPENDFGIKFNCENGGPAPDAFTNHIYKITTEIKEYKLVRNLQ---- 163
            .|.|...||::|||||   |:.|.|.|...:||.   ...:.|...|:..|:|     ||:
Human   152 SHLKLCAGIMITASHN---PKQDNGYKVYWDNGA---QIISPHDKGISQAIEE-----NLEPWPQ 205

  Fly   164 ------IDISKVGVTSFDIAGKPFTVEVIDSVAN-YVRHMEEIFDFAKLKDFVSGKATGKPLKMR 221
                  ||.|            |.......|:.| |         |..||.:...::..:..|::
Human   206 AWDDSLIDSS------------PLLHNPSASINNDY---------FEDLKKYCFHRSVNRETKVK 249

  Fly   222 I--DAMNGVTGSYVREIF-LNRLGATESSVVHTTPLPDFGGL-HPDPN-----LTYAKDLVD-TV 276
            .  .:::||..|:|:..| ...|...|:......|.|:|..: :|:|.     ||.:..|.| |.
Human   250 FVHTSVHGVGHSFVQSAFKAFDLVPPEAVPEQKDPDPEFPTVKYPNPEEGKGVLTLSFALADKTK 314

  Fly   277 AQGDYDIGAAFDGDGDRNMII---GSKAFFVTPSDSLAVIAHYLEAIPYFQKNGVQGFAR----- 333
            |:    |..|.|.|.||..:.   .|..:.|...:.|..:..:.....:.:||..:...:
Human   315 AR----IVLANDPDADRLAVAEKQDSGEWRVFSGNELGALLGWWLFTSWKEKNQDRSALKDTYML 375

  Fly   334 -SMPTASAVDLVGRKLGKEVFEVPTGWKYFGN----LMDAGRLCLCG-EESFG-TGSNHIREKDG 391
             |..::..:..:..|.|....|..||:|:.||    |:|.|:..|.. ||:.| .....:.:|||
Human   376 SSTVSSKILRAIALKEGFHFEETLTGFKWMGNRAKQLIDQGKTVLFAFEEAIGYMCCPFVLDKDG 440

  Fly   392 IWAVL---AWISVMQHTGKGIEDILKQHWSVYG-----RNYFTRYDYEECASDPCNEMVATMEKT 448
            :.|.:   ...|.:......:...||..:..||     .:||..:|.|            |::|.
Human   441 VSAAVISAELASFLATKNLSLSQQLKAIYVEYGYHITKASYFICHDQE------------TIKKL 493

  Fly   449 I-TAPEFVGK-SYSSGGKTYKVKEADNFS--YTD--PVDKSV----ATKQGLRIVFEDGSRIVVR 503
            . ....:.|| :|......:::....:.:  |.|  |..|:|    .:.|.:...|.:|....:|
Human   494 FENLRNYDGKNNYPKACGKFEISAIRDLTTGYDDSQPDKKAVLPTSKSSQMITFTFANGGVATMR 558

  Fly   504 LSGT 507
            .|||
Human   559 TSGT 562

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.