DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm1 and Pgm2

DIOPT Version :9

Sequence 1:	NP_524675.1	Gene:	Pgm1 / 44010	FlyBaseID:	FBgn0003076	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001099477.2	Gene:	Pgm2 / 289632	RGDID:	1306061	Length:	620	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	142/584 - (24%)
Similarity:	217/584 - (37%)	Gaps:	130/584 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTVEIVATKPYEGQKP------------GTSGLR-------KKVKVFTQPNYTENFVQAILEANG 48
            ||.|.|.....||.|.            ||:|||       .::...|....|:.|.: .||...
  Rat    38 LTSESVKQLLAEGNKEELEKCFGARMEFGTAGLRAPMGAGISRMNDLTIIQTTQGFCR-YLEKQF 101

  Fly    49 AALAGSTLVVGGDGRFY------CKEAAELIVRLSAANGVSKLLVGQNGILSTPAVSSLIRHNKA 107
            :.|....:|:..|||.:      .:..|.|......:.||...|.  :.|..||.|...:.|.|.
  Rat   102 SDLKQRGVVISFDGRAHPASGGSSRRFARLAATAFISQGVPVHLF--SDITPTPFVPYTVSHLKL 164

  Fly   108 LGGIVLTASHNPGGPENDFGIKFNCENGGPAPDAFTNHIYKITTEIKEYKLVRNLQ--------- 163
            ..||::|||||   |:.|.|.|...:||.   ...:.|...|:..|:|     ||:
  Rat   165 CAGIMITASHN---PKQDNGYKVYWDNGA---QIISPHDRGISQAIEE-----NLEPWPQAWDES 218

  Fly   164 -IDISKVGVTSFDIAGKPFTVEVIDSVAN-YVRHMEEIFDFAKLKDFVSGKATGKPLKMRI--DA 224
             ||       |..:...|.|     |::| |         |..||.:...:...:..:::.  .:
  Rat   219 LID-------SSSLLHNPST-----SISNDY---------FEDLKKYCFHRTVNRESQVKFVHTS 262

  Fly   225 MNGVTGSYVREIF-LNRLGATESSVVHTTPLPDFGGL-HPDPN-----LTYAKDLVDTVAQGDYD 282
            ::||...:|:..| ...|...|:......|.|:|..: :|:|.     ||.:.:|.|.:..   .
  Rat   263 VHGVGHEFVQSAFKAFDLNPPEAVPQQKDPDPEFPTVKYPNPEEGKGVLTLSFELADKIKA---K 324

  Fly   283 IGAAFDGDGDRNMII---GSKAFFVTPSDSLAVIAHYLEAIPYFQKNGVQGFARSMPTASAVDLV 344
            |..|.|.|.||..:.   .|..:.|...:.|..:..:.....:.:||  ||.:....|......|
  Rat   325 IVLANDPDADRLAVAEKQDSGEWRVFSGNELGALLGWWLFTSWKEKN--QGQSNLKDTYMLSSTV 387

  Fly   345 GRKL-----GKEVF---EVPTGWKYFGN----LMDAGRLCLCG-EESFG-TGSNHIREKDGIWAV 395
            ..|:     .||.|   |..||:|:.||    |:|.|:..|.. ||:.| .....:.:|||:.|.
  Rat   388 SSKILRAIALKEGFHFEETLTGFKWMGNRAKQLIDQGKTVLFAFEEAIGYMCCPFVLDKDGVSAA 452

  Fly   396 L---AWISVMQHTGKGIEDILKQHWSVYG-----RNYFTRYD-------YEECAS-DPCNEMVAT 444
            :   ..:|.:......:...||..:..||     .:||..:|       :|...: |..|:...|
  Rat   453 VISAELVSFLATKNLSLSLQLKAIYLEYGYHITTASYFICHDQGTIQKLFENLRNYDGKNKYPKT 517

  Fly   445 MEK-TITAPEFVGKSYSSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLSGT 507
            ..| .|:|...:...|.|.....|.        ..|..||   .|.:...|.:|....:|.|||
  Rat   518 CGKFEISAVRDLTTGYDSNQPDKKA--------VLPTSKS---SQMITFTFVNGGVATMRTSGT 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm1	NP_524675.1	PLN02307	1..560	CDD:177942	142/584 (24%)
Pgm1	NP_524675.1	PGM1	6..560	CDD:100087	140/581 (24%)
Pgm2	NP_001099477.2	PTZ00150	19..620	CDD:240294	142/584 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840