DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm1 and SPBC32F12.10

DIOPT Version :9

Sequence 1:	NP_524675.1	Gene:	Pgm1 / 44010	FlyBaseID:	FBgn0003076	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_596153.1	Gene:	SPBC32F12.10 / 2540254	PomBaseID:	SPBC32F12.10	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	564	Identity:	295/564 - (52%)
Similarity:	383/564 - (67%)	Gaps:	19/564 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VEIVATKPYEGQKPGTSGLRKKVKVFTQPNYTENFVQAILEANGAALAGSTLVVGGDGRFYCKEA 69
            :|.:.|||||||:||||||||||.||.||||.||||||.::....:..|:.||||||||::...|
pombe     2 IETIPTKPYEGQRPGTSGLRKKVTVFEQPNYVENFVQATMDVVEPSAKGAHLVVGGDGRYFNFHA 66

  Fly    70 AELIVRLSAANGVSKLLVGQNGILSTPAVSSLIRHNKALGGIVLTASHNPGGPENDFGIKFNCEN 134
            .::|..::|.|||.|::||.||.|||||.|.:||..|..|||:||||||.|||:||||||:|..|
pombe    67 IQVIAAIAAGNGVEKIIVGTNGYLSTPAASHIIRKYKLTGGIILTASHNAGGPKNDFGIKYNLGN 131

  Fly   135 GGPAPDAFTNHIYKITTEIKEYKLVRNLQIDISKVGVTSFDIAGKPFTVEVIDSVANYVRHMEEI 199
            |||||::.|..||.||..|.|||:|:...:|::..||..:.    |.||||||.|.:||:.|:||
pombe   132 GGPAPESVTEKIYSITKTISEYKMVKIPPLDLTTTGVRRYG----PLTVEVIDPVKDYVQLMKEI 192

  Fly   200 FDFAKLKDFVSGKATGKPLKMRIDAMNGVTGSYVREIFLNRLGATESSVVHTTPLPDFGGLHPDP 264
            |||..::.|:|   .........||::|:||.|...:|...||...|...:..|||||||.||||
pombe   193 FDFDLIRSFLS---KNPDFTFVFDALHGITGPYGEALFCKELGMPSSVCQNCKPLPDFGGGHPDP 254

  Fly   265 NLTYAKDLVDTVAQGDYDIGAAFDGDGDRNMIIGSKAFFVTPSDSLAVIAHYLEAIPYFQKNGVQ 329
            ||||||.||..|.:.:..:|||.|||||||||.|:.| |||||||:|:|||:.|.||||:..||.
pombe   255 NLTYAKSLVARVDRDNIVMGAASDGDGDRNMIYGANA-FVTPSDSVAIIAHHAELIPYFRDGGVH 318

  Fly   330 GFARSMPTASAVDLVGRKLGKEVFEVPTGWKYFGNLMDAGRLCLCGEESFGTGSNHIREKDGIWA 394
            ||||||||:.|:|.||:..||.|:|||||||:|.||.||.||.:||||||||||:|||||||:|.
pombe   319 GFARSMPTSGAIDRVGKYKGKNVYEVPTGWKFFCNLFDAKRLSICGEESFGTGSDHIREKDGVWG 383

  Fly   395 VLAWISVMQHTG------KGIEDILKQHWSVYGRNYFTRYDYEECASDPCNEMVATMEKTITAPE 453
            :|.|::::....      |.:.|:.|..:::|||.:::||||||..::...:::..|........
pombe   384 ILCWLNILAGLNAQNPKIKTLIDVKKDFYNIYGRTFYSRYDYEELENEAAGKVMDRMRAIADDKS 448

  Fly   454 FVGKSYSSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLSGTGSSGATVRLYI 518
            .||::...|   :.|.||.:|.|.||:|.|.:..|||.|.||:|||||.|||||||||||:|||:
pombe   449 KVGEAVLPG---FVVSEAGDFEYHDPIDGSESKHQGLYIKFENGSRIVTRLSGTGSSGATLRLYM 510

  Fly   519 DSYEKENVLG--QASVMLKPLIDIALEISQLPKFTGRNAPTVIT 560
            :.:|.::...  .|.|.|||::..||||..|.:.|||..|||||
pombe   511 EKHESDSSKFDLDAQVALKPVVHAALEILALEELTGRKEPTVIT 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm1	NP_524675.1	PLN02307	1..560	CDD:177942	293/562 (52%)
Pgm1	NP_524675.1	PGM1	6..560	CDD:100087	293/561 (52%)
SPBC32F12.10	NP_596153.1	PLN02307	2..554	CDD:177942	293/562 (52%)
SPBC32F12.10	NP_596153.1	PGM1	3..554	CDD:100087	293/561 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I848
eggNOG	1	0.900	-	-		E1_COG0033
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1979
Inparanoid	1	1.050	569	1.000	Inparanoid score	I179
OMA	1	1.010	-	-		QHG54024
OrthoFinder	1	1.000	-	-		FOG0001684
OrthoInspector	1	1.000	-	-		oto100678
orthoMCL	1	0.900	-	-		OOG6_100937
Panther	1	1.100	-	-	LDO	PTHR22573
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R914
SonicParanoid	1	1.000	-	-		X1241
TreeFam	1	0.960	-	-
	14	13.860