DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm1 and Pgm1

DIOPT Version :9

Sequence 1:	NP_524675.1	Gene:	Pgm1 / 44010	FlyBaseID:	FBgn0003076	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_006238504.1	Gene:	Pgm1 / 24645	RGDID:	3316	Length:	580	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	324/558 - (58%)
Similarity:	414/558 - (74%)	Gaps:	9/558 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ATKPYEGQKPGTSGLRKKVKVFTQ-PNYTENFVQAI-LEANGAALAGSTLVVGGDGRFYCKEAAE 71
            ||.||..||||||||||....|.: |.|.|||:|:| ...:.....||:||||||||::.|.|.|
  Rat    26 ATVPYHDQKPGTSGLRKNTYYFEEKPCYLENFIQSIFFSIDLKDRQGSSLVVGGDGRYFNKSAIE 90

  Fly    72 LIVRLSAANGVSKLLVGQNGILSTPAVSSLIRHNKALGGIVLTASHNPGGPENDFGIKFNCENGG 136
            .:|:::||||:.:|::||||||||||||.:||..||:|||:||||||||||..|||||||..|||
  Rat    91 TVVQMAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNPGGPNGDFGIKFNISNGG 155

  Fly   137 PAPDAFTNHIYKITTEIKEYKLVRNLQIDISKVGVTSFDIAG--KPFTVEVIDSVANYVRHMEEI 199
            |||:|.|:.|::|:..|:||.:..:|::|:|.:|...||:..  ||||||::|||..|...:..|
  Rat   156 PAPEAITDKIFQISKTIEEYAICPDLKVDLSVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRNI 220

  Fly   200 FDFAKLKDFVSGKATGKPLKMRIDAMNGVTGSYVREIFLNRLGATESSVVHTTPLPDFGGLHPDP 264
            |||..||:.:||.   ..||:|||||:||.|.||::|....|||..:|.|:..||.||||.||||
  Rat   221 FDFNALKELLSGP---NRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPDP 282

  Fly   265 NLTYAKDLVDTVAQGDYDIGAAFDGDGDRNMIIGSKAFFVTPSDSLAVIAHYLEAIPYFQKNGVQ 329
            |||||.|||:|:..|::|.|||||||||||||:|...|||.||||:||||..:.:|||||:.||:
  Rat   283 NLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVR 347

  Fly   330 GFARSMPTASAVDLVGRKLGKEVFEVPTGWKYFGNLMDAGRLCLCGEESFGTGSNHIREKDGIWA 394
            ||||||||:.|:|.|.......::|.|||||:|||||||.:|.|||||||||||:|||||||:||
  Rat   348 GFARSMPTSGALDRVANATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWA 412

  Fly   395 VLAWISVMQHTGKGIEDILKQHWSVYGRNYFTRYDYEECASDPCNEMVATMEKTITAPEFVGKSY 459
            ||||:|::....:.:|||||.||..:|||:||||||||..::..|:|:..:|..:....||||.:
  Rat   413 VLAWLSILATRKQSVEDILKDHWQKFGRNFFTRYDYEEVEAEGANKMMKDLEALMLDRSFVGKQF 477

  Fly   460 SSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLSGTGSSGATVRLYIDSYEKE 524
            |:..|.|.|::||||.|:||||.|::..||||::|.|||||:.|||||||:|||:|||||||||:
  Rat   478 SANDKVYTVEKADNFEYSDPVDGSISKNQGLRLIFADGSRIIFRLSGTGSAGATIRLYIDSYEKD 542

  Fly   525 --NVLGQASVMLKPLIDIALEISQLPKFTGRNAPTVIT 560
              .:.....|||.|||.|||::|||.:.|||.||||||
  Rat   543 AAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm1	NP_524675.1	PLN02307	1..560	CDD:177942	322/556 (58%)
Pgm1	NP_524675.1	PGM1	6..560	CDD:100087	322/556 (58%)
Pgm1	XP_006238504.1	PGM1	24..580	CDD:100087	324/558 (58%)
Pgm1	XP_006238504.1	PLN02307	27..580	CDD:177942	323/557 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335267
Domainoid	1	1.000	188	1.000	Domainoid score	I3222
eggNOG	1	0.900	-	-		E1_COG0033
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1979
Inparanoid	1	1.050	661	1.000	Inparanoid score	I729
OMA	1	1.010	-	-		QHG54024
OrthoDB	1	1.010	-	-		D175278at33208
OrthoFinder	1	1.000	-	-		FOG0001684
OrthoInspector	1	1.000	-	-		otm44714
orthoMCL	1	0.900	-	-		OOG6_100937
Panther	1	1.100	-	-	LDO	PTHR22573
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810