Protein Alignment Hex-C and HXK2

DIOPT Version :9

• Sequence 1: NP_524674.1
• Gene: Hex-C / 44008
• FlyBaseID: FBgn0001187
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_011261.1
• Gene: HXK2 / 852639
• SGDID: S000003222
• Length: 486
• Species: Saccharomyces cerevisiae
• Alignment Length: 476
• Identity: 165/476 - (34%)
• Similarity: 252/476 - (52%)
• Gaps: 53/476 - (11%)

  Fly     7 RELMQP-------FVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKY 64
            :||||.       |.:....:|.|...|..|:.:||.:.   ..|:...|.:|.|.|||.|.|.:
Yeast    21 KELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMDFPTGKESGDF 82

  Fly    65 LALDLGGTNFRVLLVSLKGHHDATVDS--QIYAVPKDLMVGPGVD-LFDHIAGCLAKFVEKHDMK 126
            ||:||||||.||:||.|.|  |.|.|:  ..|.:|..:......| |::.||..|..|:::...:
Yeast    83 LAIDLGGTNLRVVLVKLGG--DRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQ 145

  Fly   127 --TAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAIL 189
              :..:|||||||||..|..:.||||.|||||||...:|..||..||.:.|.:| :..|.|||::
Yeast   146 GISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKR-NIPIEVVALI 209

  Fly   190 NDTTGTLMSCAHRNADCRVGVIVGTGCNACYVE---DVENVDLLRADFKKTKRSVIVNAEWGAFG 251
            |||||||::..:.:.:.::|||.|||.|..|.:   |:|.:....:|.......:.:|.|:|:|
Yeast   210 NDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF- 273

  Fly   252 EGGQLDFVRTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFA 316
            :...:...||:||..:||:|....:|.||||::|.|||.::||.|:...::..|||...
Yeast   274 DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQD------ 332

  Fly   317 SVLQRNEE--VFETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAAT 379
              |.:.::  |.:|.|.:.||:|.|.....|..:.:|.||: ..:|::.:.:|.:.|.:..|||.
Yeast   333 --LSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGI-NTTVQERKLIRRLSELIGARAAR 394

  Fly   380 LVAIGVSGLVNRTSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKE---W----------D 431
            |...|::.:..:...:...:..|||||..:|.|.       :|...|.|:   |          .
Yeast   395 LSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFK-------EKAANALKDIYGWTQTSLDDYPIK 452

  Fly   432 IMLSEDGSGRGAALVAAVASK 452
            |:.:|||||.|||::||:|.|
Yeast   453 IVPAEDGSGAGAAVIAALAQK 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	84/204 (41%)
		PTZ00107	13..454	CDD:240270	161/463 (35%)
		Hexokinase_2	207..449	CDD:281689	78/259 (30%)
HXK2	NP_011261.1	COG5026	6..478	CDD:227359	165/476 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I1047
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	270	1.000	Inparanoid score	I600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56451
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9160
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	13	12.830