Protein Alignment Hex-C and GLK1

DIOPT Version :9

• Sequence 1: NP_524674.1
• Gene: Hex-C / 44008
• FlyBaseID: FBgn0001187
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_009890.1
• Gene: GLK1 / 850317
• SGDID: S000000545
• Length: 500
• Species: Saccharomyces cerevisiae
• Alignment Length: 506
• Identity: 157/506 - (31%)
• Similarity: 250/506 - (49%)
• Gaps: 84/506 - (16%)

  Fly     6 VRELMQPFVLSDYQVQEVYSRFCLEVARGL--KRSTHPQANVK---CFPTYVQDLPTGDEMGKYL 65
            |.::...|.::..::.|:.:.|..::.:||  .:..|..|:.|   ..|.:|...|.|.|.|..|
Yeast    18 VDQICDDFEVTPEKLDELTAYFIEQMEKGLAPPKEGHTLASDKGLPMIPAFVTGSPNGTERGVLL 82

  Fly    66 ALDLGGTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGV---DLFDHIAGCLAKFVEKH---- 123
            |.||||||||:..|:|.|.|..:::.....:|.||:....|   |||..:|.....|::|:
Yeast    83 AADLGGTNFRICSVNLHGDHTFSMEQMKSKIPDDLLDDENVTSDDLFGFLARRTLAFMKKYHPDE 147

  Fly   124 -----DMKTAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADI 183
                 |.|.  :.||||||:|..|..|..|.|:||||||..|...|:||.::..|.:..:|...|
Yeast   148 LAKGKDAKP--MKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKDVVQLYQEQLSAQGMPMI 210

  Fly   184 AVVAILNDTTGTLMSCAHR--NADCR---------VGVIVGTGCNACYVEDVENVDLLRAD---- 233
            .|||:.|||.||.:|..:.  |.|..         :|.|.|||.|.||:|::..:..|..:
Yeast   211 KVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIFGTGTNGCYMEEINKITKLPQELRDK 275

  Fly   234 -FKKTKRSVIVNAEWGAFGEGGQLDFV-RTEYDREVDEK-SLNRSEQLFEKMTAGMYLGNLVRLV 295
             .|:.|..:|:|.|||:|  ..:|..: .|:||..:|:| |.|....||||..:||:||.::|.:
Yeast   276 LIKEGKTHMIINVEWGSF--DNELKHLPTTKYDVVIDQKLSTNPGFHLFEKRVSGMFLGEVLRNI 338

  Fly   296 LLRALERKLIFKQSSRRPE----FASVLQRNEEVFETRYISEIE-DDSFPEFASTRKIVKNLFGL 355
            |:....:.|:.:|...:.:    ..:..|.:.||     :|.|| |||              .||
Yeast   339 LVDLHSQGLLLQQYRSKEQLPRHLTTPFQLSSEV-----LSHIEIDDS--------------TGL 384

  Fly   356 EKASVEDCQTLRY------------ICECVAKRAATLVAIGVSGLVNRTS--NRR----VIVGMD 402
            .:..:...|:||.            :...:::|:|.|.|:.::.::.:|:  |:|    |.:|.|
Yeast   385 RETELSLLQSLRLPTTPTERVQIQKLVRAISRRSAYLAAVPLAAILIKTNALNKRYHGEVEIGCD 449

  Fly   403 GSVYRYHPKFDAYMRQTLQKL---VKADKEWDIMLSEDGSGRGAALVAAVA 450
            |||..|:|.|.:.:|..|...   .:.:::..:.:::||||.||||.|.||
Yeast   450 GSVVEYYPGFRSMLRHALALSPLGAEGERKVHLKIAKDGSGVGAALCALVA 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	74/210 (35%)
		PTZ00107	13..454	CDD:240270	156/499 (31%)
		Hexokinase_2	207..449	CDD:281689	79/283 (28%)
GLK1	NP_009890.1	COG5026	1..500	CDD:227359	155/504 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56451
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	8	7.780