DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and HXK1

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_194642.1	Gene:	HXK1 / 829034	AraportID:	AT4G29130	Length:	496	Species:	Arabidopsis thaliana

Alignment Length:	451	Identity:	154/451 - (34%)
Similarity:	242/451 - (53%)	Gaps:	38/451 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLGGTNFRVLLVSLKG 83
            ::::|.....:|:..||  ::...:.:|...:||.:||:|||.|.:.|||||||||||:.|.|.|
plant    54 KLRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGG 116

  Fly    84 HHDATVDSQI--YAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLP------LGFTFSFPC 140
            ..:..|..:.  .::|..||.|...:||:.||..|||||.. :.:..:||      ||||||||.
plant   117 KQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVAT-ECEDFHLPEGRQRELGFTFSFPV 180

  Fly   141 VQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNAD 205
            .|..|..|.|::|||||......|:||...|::|::|.| .|:.:.|::|||.|||....:.|.|
plant   181 KQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLAGGRYYNPD 244

  Fly   206 CRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDEK 270
            ....||:|||.||.|||....:........|: ..:::|.|||.| ....|..  ||:|..:|.:
plant   245 VVAAVILGTGTNAAYVERATAIPKWHGLLPKS-GEMVINMEWGNF-RSSHLPL--TEFDHTLDFE 305

  Fly   271 SLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQ---SSRRPEFASVLQRNEEVFETRYIS 332
            |||..||:.||:.:|||||.::|.|||:..|....|..   |..|..|         :..|.::|
plant   306 SLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPF---------IIRTPHMS 361

  Fly   333 EIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNR-----T 392
            .:.:|:.|:.......:|::..:...|::..:.:..:|..:|.|.|.|.|.|:.|::.:     |
plant   362 AMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTT 426

  Fly   393 SNRRV---IVGMDGSVYRYHPKFDAYMRQTLQKLV--KADKEWDIMLSEDGSGRGAALVAA 448
            .:..|   ::.|||.::.::.:|...|..:|::|:  :|....::..|.||||.||||:||
plant   427 KDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAA 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	75/188 (40%)
		PTZ00107	13..454	CDD:240270	154/451 (34%)
		Hexokinase_2	207..449	CDD:281689	77/255 (30%)
HXK1	NP_194642.1	PLN02405	1..496	CDD:215226	154/451 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840