DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hex-C and HKDC1

DIOPT Version :9

Sequence 1:NP_524674.1 Gene:Hex-C / 44008 FlyBaseID:FBgn0001187 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_079406.4 Gene:HKDC1 / 80201 HGNCID:23302 Length:917 Species:Homo sapiens


Alignment Length:457 Identity:193/457 - (42%)
Similarity:296/457 - (64%) Gaps:25/457 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDL 69
            ::..::..|.|:..|:.:|.::...|:..|||:.:|..|.|:..||||..||.|.|.||:|||||
Human   469 QIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDL 533

  Fly    70 GGTNFRVLLVSLK-GHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLG 133
            ||||||||||.:: |.....:.::|:|:|.::|.|.|.:|||||..|:|.|::...:|.|.||||
Human   534 GGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLG 598

  Fly   134 FTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMS 198
            |||||||.|:.:.:|.|:.|||||.....|||||..||.|||:||.:.|:.:||::|||.||:|:
Human   599 FTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMT 663

  Fly   199 CAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEY 263
            |.:.:.:|.:|:|.|||.|.||:||:.|::::.....|    :.:|.|||.||:.|.:|.:.|.|
Human   664 CGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGK----MCINTEWGGFGDNGCIDDIWTRY 724

  Fly   264 DREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFK-QSSRRPEFASVLQRNEEVFE 327
            |.||||.|||..:|.:||||:|||||.:||.:|:...::.|:|: |.|.|       .|...:||
Human   725 DTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISER-------LRTRGIFE 782

  Fly   328 TRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNR- 391
            |:::|:||.|.. .....|:|::.| ||: ::.||...::.:|..|::|||.|...|::.:|.: 
Human   783 TKFLSQIESDRL-ALLQVRRILQQL-GLD-STCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKR 844

  Fly   392 -----TSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLV-KADKEWDIMLSEDGSGRGAALVAAVA 450
                 ..:.|:.||:||::|:.||.|...:::|:::|. :.|..:  ||||||||:||||:.|||
Human   845 REDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTF--MLSEDGSGKGAALITAVA 907

  Fly   451 SK 452
            .:
Human   908 KR 909

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Hex-CNP_524674.1 Hexokinase_1 5..200 CDD:278764 93/195 (48%)
PTZ00107 13..454 CDD:240270 193/449 (43%)
Hexokinase_2 207..449 CDD:281689 95/249 (38%)
HKDC1NP_079406.4 Mitochondrial-binding peptide (MBP). /evidence=ECO:0000305|PubMed:30517626 1..20
Hexokinase_1 21..219 CDD:376323
PLN02914 26..462 CDD:178502
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 73..207
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 84..91
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 172..173
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 208..447
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 208..209
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 291..294
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 413..415
PTZ00107 466..907 CDD:240270 191/453 (42%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 521..654 70/132 (53%)
Glucose-6-phosphate 2 binding. /evidence=ECO:0000250|UniProtKB:P19367 532..536 3/3 (100%)