DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hex-C and HKDC1

DIOPT Version :10

Sequence 1:NP_524674.1 Gene:Hex-C / 44008 FlyBaseID:FBgn0001187 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_079406.4 Gene:HKDC1 / 80201 HGNCID:23302 Length:917 Species:Homo sapiens


Alignment Length:457 Identity:193/457 - (42%)
Similarity:296/457 - (64%) Gaps:25/457 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDL 69
            ::..::..|.|:..|:.:|.::...|:..|||:.:|..|.|:..||||..||.|.|.||:|||||
Human   469 QIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDL 533

  Fly    70 GGTNFRVLLVSLK-GHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLG 133
            ||||||||||.:: |.....:.::|:|:|.::|.|.|.:|||||..|:|.|::...:|.|.||||
Human   534 GGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLG 598

  Fly   134 FTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMS 198
            |||||||.|:.:.:|.|:.|||||.....|||||..||.|||:||.:.|:.:||::|||.||:|:
Human   599 FTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMT 663

  Fly   199 CAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEY 263
            |.:.:.:|.:|:|.|||.|.||:||:.|::::.....|    :.:|.|||.||:.|.:|.:.|.|
Human   664 CGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGK----MCINTEWGGFGDNGCIDDIWTRY 724

  Fly   264 DREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFK-QSSRRPEFASVLQRNEEVFE 327
            |.||||.|||..:|.:||||:|||||.:||.:|:...::.|:|: |.|.|       .|...:||
Human   725 DTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISER-------LRTRGIFE 782

  Fly   328 TRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNR- 391
            |:::|:||.|.. .....|:|::.| ||: ::.||...::.:|..|::|||.|...|::.:|.: 
Human   783 TKFLSQIESDRL-ALLQVRRILQQL-GLD-STCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKR 844

  Fly   392 -----TSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLV-KADKEWDIMLSEDGSGRGAALVAAVA 450
                 ..:.|:.||:||::|:.||.|...:::|:::|. :.|..:  ||||||||:||||:.|||
Human   845 REDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTF--MLSEDGSGKGAALITAVA 907

  Fly   451 SK 452
            .:
Human   908 KR 909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hex-CNP_524674.1 ASKHA_NBD_HK_meta 14..448 CDD:466869 189/442 (43%)
HKDC1NP_079406.4 Mitochondrial-binding peptide (MBP). /evidence=ECO:0000305|PubMed:30517626 1..20
ASKHA_NBD_HKDC1_meta_rpt1 30..458 CDD:466976
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 73..207
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 208..447
ASKHA_NBD_HKDC1_meta_rpt2 478..910 CDD:466980 192/448 (43%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 521..654 70/132 (53%)
Hexokinase large subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 655..894 94/254 (37%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.