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Protein Alignment Hex-C and HK3

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_002106.2	Gene:	HK3 / 3101	HGNCID:	4925	Length:	923	Species:	Homo sapiens

Alignment Length:	455	Identity:	187/455 - (41%)
Similarity:	277/455 - (60%)	Gaps:	29/455 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLG 70
            :.|.:.||.|:..|:..|.::....:|:||:...   ::::..||:|:..|.|.|.|.:||||||
Human   483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEA---SSLRMLPTFVRATPDGSERGDFLALDLG 544

  Fly    71 GTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFT 135
            |||||||||.:.  ....:.|:||::|:.:..|.|..|||||..|:..|.:|..:....||||||
Human   545 GTNFRVLLVRVT--TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFT 607

  Fly   136 FSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCA 200
            |||||.||||.:|||:.|||||..:..||:||..:|.|||.||...::.||||:|||.||:|||.
Human   608 FSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCG 672

  Fly   201 HRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDR 265
            :.:..|.:|:|||||.||||:|::.||..:..|..:    :.:|.||||||:.|.|..:.|.:|.
Human   673 YEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGR----MCINMEWGAFGDDGSLAMLSTRFDA 733

  Fly   266 EVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQR--NEEVFET 328
            .||:.|:|..:|.||||.:|||||.:||.:||......::|:        ...:||  ..::|:|
Human   734 SVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR--------GQQIQRLQTRDIFKT 790

  Fly   329 RYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTS 393
            :::||||.||. .....|.|:::| ||...| :|...:..:|:.|::|||.|...||:.:|.:..
Human   791 KFLSEIESDSL-ALRQVRAILEDL-GLPLTS-DDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIR 852

  Fly   394 NRR------VIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVASK 452
            ..|      |.||:||::|:.||:|.:.:..|:::|...... ..:.||||||:|||||.|||.:
Human   853 ENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVV-TFLQSEDGSGKGAALVTAVACR 916

Fly 453 452
Human 917 916

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.