DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and HK2

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_005264337.1	Gene:	HK2 / 3099	HGNCID:	4923	Length:	938	Species:	Homo sapiens

Alignment Length:	448	Identity:	206/448 - (45%)
Similarity:	291/448 - (64%)	Gaps:	30/448 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLGGTNFRVLLV 79
            |||..:.|:..||..|:.:||..:|||.|.||..||:|:..|.|.|.|::|||||||||||||.|
Human    31 LSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWV 95

  Fly    80 SL--KGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFTFSFPCVQ 142
            .:  .|.....:::||||:|:|:|.|.|..||||||.|||.|::|..:|...|||||||||||.|
Human    96 KVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQ 160

  Fly   143 LGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNADCR 207
            ..|.|..||.|||||..:||||.||..::.:|||||||.||.:||::|||.||:|:|.:.:.:|.
Human   161 TKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCE 225

  Fly   208 VGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDEKSL 272
            :|:|||||.||||:|::.::|::..|    :..:.:|.||||||:.|.|:.:|||:|:|:|..||
Human   226 IGLIVGTGSNACYMEEMRHIDMVEGD----EGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSL 286

  Fly   273 NRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIF--KQSSRRPEFASVLQRNEEVFETRYISEIE 335
            |..:||||||.:|||:|.||||:|::..:.:|:|  |.|   ||..     |...|||:.||:||
Human   287 NPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLS---PELL-----NTGRFETKDISDIE 343

  Fly   336 DDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTSNR----- 395
            .:. ......|:::..| ||:... |||.....||:.|:.|:|:|.|..::.::.|....
Human   344 GEK-DGIRKAREVLMRL-GLDPTQ-EDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEER 405

  Fly   396 -RVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDI--MLSEDGSGRGAALVAAVA 450
             |..:|:|||||:.||.|...:.:|:::||..   .|:  :.||||||:|||:|.|||
Human   406 LRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG---CDVRFLRSEDGSGKGAAMVTAVA 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	102/186 (55%)
		PTZ00107	13..454	CDD:240270	206/448 (46%)
		Hexokinase_2	207..449	CDD:281689	99/251 (39%)
HK2	XP_005264337.1	PTZ00107	12..460	CDD:240270	204/446 (46%)
		Hexokinase_1	21..219	CDD:278764	103/187 (55%)
		Hexokinase_2	225..459	CDD:281689	99/251 (39%)
		PTZ00107	462..929	CDD:240270
		Hexokinase_1	471..688	CDD:278764
		Hexokinase_2	694..928	CDD:281689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147064
Domainoid	1	1.000	207	1.000	Domainoid score	I2879
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8559
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.750