DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and hxk1

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_592948.1	Gene:	hxk1 / 2542634	PomBaseID:	SPAC24H6.04	Length:	484	Species:	Schizosaccharomyces pombe

Alignment Length:	457	Identity:	177/457 - (38%)
Similarity:	265/457 - (57%)	Gaps:	16/457 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LDAEVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLA 66
            |...:.||.:.|.:....:..|..||..|:.:||  :|:| .:|...||::...|.|:|.|.|||
pombe    27 LQDHLDELEEQFTIPTELLHRVTDRFVSELYKGL--TTNP-GDVPMVPTWIIGTPDGNEHGSYLA 88

  Fly    67 LDLGGTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEK-HDMKTAYL 130
            |||||||.||..|.::|:....:....|.:|::|.||....|||:||.|:.||||: |..|:..|
pombe    89 LDLGGTNLRVCAVEVQGNGKFDITQSKYRLPQELKVGTREALFDYIADCIKKFVEEVHPGKSQNL 153

  Fly   131 PLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGT 195
            .:|||||:||||..:.:..||.||||||..|||||.||.:|..|::|.|..::.:.|||:|||||
pombe   154 EIGFTFSYPCVQRSINDASLVAWTKGFDIDGVEGESVGPLLSAALKRVGCNNVRLNAILSDTTGT 218

  Fly   196 LMSCAHRNADCRVGVIVGTGCNACYVEDVENVDLL-RADFKKTKRSVIVNAEWGAFGEGGQLDFV 259
            |::..:.:....:|||.||||||||:|....:..| :.||.: ..::|:|.||..| :...:...
pombe   219 LVASNYASPGTEIGVIFGTGCNACYIEKFSEIPKLHKYDFPE-DMNMIINCEWCDF-DNQHVVLP 281

  Fly   260 RTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEE 324
            ||:||..:||:|.....|.:|||.||.|||:::|.:||...|:..:|...    :...:  |:..
pombe   282 RTKYDVAIDEESPRPGLQTYEKMIAGCYLGDILRRILLDLYEQGALFNGQ----DVTKI--RDPL 340

  Fly   325 VFETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLV 389
            ..:|..:|.||.|.|.....|:.:.:..:|| |.:.|:.|.:|..||.:..|:|.|.|.||..||
pombe   341 AMDTSVLSAIEVDPFENLDETQTLFEETYGL-KTTEEERQFIRRACELIGTRSARLSACGVCALV 404

  Fly   390 NRTSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIML--SEDGSGRGAALVAAVASK 452
            .:.:...:|||.|||||..:|:|...:.|..:.::..:....::.  :|||||.|||||:|:.:|
pombe   405 RKMNKPSMIVGTDGSVYNLYPRFKDRLAQAFKDILGEEIGSKVVTIPAEDGSGVGAALVSALEAK 469

  Fly   453 TK 454
            .|
pombe   470 GK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	87/195 (45%)
		PTZ00107	13..454	CDD:240270	173/444 (39%)
		Hexokinase_2	207..449	CDD:281689	86/244 (35%)
hxk1	NP_592948.1	COG5026	10..474	CDD:227359	177/457 (39%)
		Hexokinase_1	30..224	CDD:278764	87/196 (44%)
		Hexokinase_2	230..466	CDD:281689	86/244 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	169	1.000	Domainoid score	I906
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	302	1.000	Inparanoid score	I598
OMA	1	1.010	-	-		QHG56451
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		otm47135
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	13	12.830