DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and Gck

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001257778.1	Gene:	Gck / 24385	RGDID:	2670	Length:	498	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	185/410 - (45%)
Similarity:	261/410 - (63%)	Gaps:	31/410 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PTGDEMGKYLALDLGGTNFRVLLVSL----KGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCL 116
            |.| |:|.:|:||||||||||:||.:    .|........|:|::|:|.|.|....|||:|:.|:
  Rat   100 PRG-EVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECI 163

  Fly   117 AKFVEKHDMKTAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDA 181
            :.|::||.||...||||||||||.....|.:|||:.|||||..:|.||.::..:|.:||:||||.
  Rat   164 SDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDF 228

  Fly   182 DIAVVAILNDTTGTLMSCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAE 246
            ::.|||::|||..|::||.:.:..|.||:||||||||||:|:::||:|:..|    :..:.||.|
  Rat   229 EMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGD----EGRMCVNTE 289

  Fly   247 WGAFGEGGQLDFVRTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSR 311
            |||||:.|:||....||||.|||.|.|..:||:||:..|.|:|.|||||||:.::..|:|...
  Rat   290 WGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGE-- 352

  Fly   312 RPEFASVLQRNEEVFETRYISEIEDDSFPEFASTRKIVKNL---FGLEKASVEDCQTLRYICECV 373
                ||...|....||||::|::|.||     ..||.:.|:   .|| :.||.||..:|..||.|
  Rat   353 ----ASEQLRTRGAFETRFVSQVESDS-----GDRKQIHNILSTLGL-RPSVTDCDIVRRACESV 407

  Fly   374 AKRAATLVAIGVSGLVNRTSN------RRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDI 432
            :.|||.:.:.|::|::||...      .|:.||:|||||:.||.|......::::|. .:.|...
  Rat   408 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLT-PNCEITF 471

  Fly   433 MLSEDGSGRGAALVAAVASK 452
            :.||:|||||||||:|||.|
  Rat   472 IESEEGSGRGAALVSAVACK 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	71/147 (48%)
		PTZ00107	13..454	CDD:240270	185/410 (45%)
		Hexokinase_2	207..449	CDD:281689	108/250 (43%)
Gck	NP_001257778.1	Hexokinase_1	<100..248	CDD:376323	72/148 (49%)
Gck	NP_001257778.1	Hexokinase_2	254..488	CDD:377112	108/250 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340733
Domainoid	1	1.000	209	1.000	Domainoid score	I2741
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1815
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9035
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.010