back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and Hkdc1

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_663394.1	Gene:	Hkdc1 / 216019	MGIID:	2384910	Length:	915	Species:	Mus musculus

Alignment Length:	457	Identity:	196/457 - (42%)
Similarity:	295/457 - (64%)	Gaps:	27/457 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDL 69
            ::.:::..|.|:..|:..|..:...|:..|||:.||..|.||..||||..:|.|.|.||:|||||
Mouse   469 QIDKVLALFQLTREQLLGVRDKMRAELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDL 533

  Fly    70 GGTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGF 134
            ||||||||||.:: .....:.::|:|:|.::|.|.|.:|||||..|:|.|::...:|.|.|||||
Mouse   534 GGTNFRVLLVKIR-RRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGF 597

  Fly   135 TFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSC 199
            ||||||.|..:.:|.||.|||||.....|||||..||.|||:||.:.|:.:|||:|||.||:|:|
Mouse   598 TFSFPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTC 662

  Fly   200 AHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYD 264
            .:.:..|.:|:|.|||.|.||:|::.|::|:..|    :..:.||.|||.||:.|.:|.:||:||
Mouse   663 GYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDGD----EGRMCVNTEWGGFGDNGCIDDIRTQYD 723

  Fly   265 REVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFK-QSSRRPEFASVLQRNEEVFET 328
            :||||.|||..:|.:||||:|||||.:||.:|:....:.|:|: |.|.|       .|...:|||
Mouse   724 KEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISER-------LRTRGIFET 781

  Fly   329 RYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNR-- 391
            :::|:||.|.. .....|:|::.| ||: ::.||...::.:|..|::|||.:...|::.:|.:
Mouse   782 KFLSQIESDRL-ALLQVRRILQQL-GLD-STCEDSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRR 843

  Fly   392 ----TSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDI--MLSEDGSGRGAALVAAVA 450
                ..:.:|.||:||::|:.||.|...:::|:::|.   .:.|:  ||||||||:||||:.|||
Mouse   844 EDQGLQHFKVTVGVDGTLYKLHPHFSRILQETVKELA---PQCDVTFMLSEDGSGKGAALITAVA 905

  Fly   451 SK 452
            .:
Mouse   906 KR 907

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.