DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and hxk-1

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001021106.1	Gene:	hxk-1 / 172751	WormBaseID:	WBGene00008780	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	457	Identity:	215/457 - (47%)
Similarity:	299/457 - (65%)	Gaps:	18/457 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLG 70
            ::|..|..||||.|::.:.......:.:||..||...| ||..||||..:|.|.|.|.:||||||
Worm    39 IQEACQRLVLSDQQLRRIMQSMEKSMEQGLATSTKKVA-VKMLPTYVDSVPNGTESGDFLALDLG 102

  Fly    71 GTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAY-LPLGF 134
            |||||||.:.|:| .:..:..:|:.||:.:|.|.|..||||||||:|||:.::|:|.|. |||||
Worm   103 GTNFRVLHIKLQG-KETKMTGKIFRVPESIMRGTGEALFDHIAGCMAKFMGENDLKDAQKLPLGF 166

  Fly   135 TFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSC 199
            ||||||.|.||.:|.||.|||||..:||||.||..:||||..||.|.||.|||:||||.||||:|
Worm   167 TFSFPCEQEGLTKGKLVTWTKGFKASGVEGVDVVTLLHEACHRRKDIDIDVVALLNDTVGTLMAC 231

  Fly   200 AHRNADCRVGVIVGTGCNACYVEDVENVDLLRA---DFKKTKRSVIVNAEWGAFGEGGQLDFVRT 261
            |.:...|::|||||||.||||:|.::.:..|..   :...|...:|:|.||||||:.|.|||:||
Worm   232 AFQENSCQIGVIVGTGTNACYMERLDRIPKLAGYVDEHGVTPEEMIINTEWGAFGDDGALDFLRT 296

  Fly   262 EYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVF 326
            |:|..||.:|:|..:.|:|||.:|||:|...|:||....::.|:|..:|   :..||    ...|
Worm   297 EWDEVVDRESINPGQHLYEKMISGMYMGECARVVLEDLAKQGLLFGGNS---DAISV----PHCF 354

  Fly   327 ETRYISEIEDDSFPE----FASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSG 387
            .|:::|||:.|...:    |..|.:|:::: |:|..:..||..:.|:|..::.|||.|.|.|::.
Worm   355 PTKFVSEIDSDLLEDDDRTFQKTYQILEDI-GVEMITANDCANVAYVCSLISTRAAHLTAAGIAM 418

  Fly   388 LVNRTSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVASK 452
            |:||.:.:.|.||:||||||:||.:...:...:.:|:..|.|:.:||||||||||||||||||::
Worm   419 LLNRMNKKHVTVGVDGSVYRFHPTYPTLLDAKIGELIVGDIEYKLMLSEDGSGRGAALVAAVATR 483

  Fly   453 TK 454
            .|
Worm   484 LK 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	105/194 (54%)
		PTZ00107	13..454	CDD:240270	212/448 (47%)
		Hexokinase_2	207..449	CDD:281689	103/248 (42%)
hxk-1	NP_001021106.1	COG5026	37..487	CDD:227359	215/457 (47%)
		Hexokinase_1	39..233	CDD:278764	106/195 (54%)
		Hexokinase_2	239..480	CDD:281689	103/248 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I1768
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	451	1.000	Inparanoid score	I900
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		otm14812
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930