DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hex-C and Hk2

DIOPT Version :9

Sequence 1:NP_524674.1 Gene:Hex-C / 44008 FlyBaseID:FBgn0001187 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_038848.1 Gene:Hk2 / 15277 MGIID:1315197 Length:917 Species:Mus musculus


Alignment Length:455 Identity:205/455 - (45%)
Similarity:289/455 - (63%) Gaps:44/455 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLGGTNFRVLLV 79
            |||..:.|:..||..|:.:||..:|||.|.||..||:|:..|.|.|.|::|||||||||||||.|
Mouse    31 LSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRV 95

  Fly    80 SL--KGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFTFSFPCVQ 142
            .:  .|.....:::||||:|:|:|.|.|..||||||.|||.|::|..:|...|||||||||||.|
Mouse    96 RVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQ 160

  Fly   143 LGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNADCR 207
            ..|.|..||.|||||..:||||.||..::.:|||||||.||.:||::|||.||:|:|.:.:.:|.
Mouse   161 TKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCE 225

  Fly   208 VGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDEKSL 272
            :|:|||||.||||:|::.::|::..|    :..:.:|.||||||:.|.|:.:|||:|||:|..||
Mouse   226 IGLIVGTGSNACYMEEMRHIDMVEGD----EGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSL 286

  Fly   273 NRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRYISEIEDD 337
            |..:||||||.:|||:|.||||:|::..:.:|:| |....||..:.     ..|||:.:|:||||
Mouse   287 NPGKQLFEKMISGMYMGELVRLILVKMAKAELLF-QGKLSPELLTT-----GSFETKDVSDIEDD 345

  Fly   338 SFPEFASTRKIVKNLFGLEKA-----------SVEDCQTLRYICECVAKRAATLVAIGVSGLV-- 389
            .              .|::||           ..|||.....||:.|:.|:|:|.|..::.::  
Mouse   346 K--------------DGIQKAYQILVRLGLSPLQEDCVATHRICQIVSTRSASLCAATLAAVLWR 396

  Fly   390 ---NRTSNR-RVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVA 450
               |:...| |..:|:|||||:.||.|...:.:.:::|| .|.:...:.||||||:|||:|.|||
Mouse   397 IKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLV-PDCDVRFLRSEDGSGKGAAMVTAVA 460

  Fly   451  450
            Mouse   461  460

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Hex-CNP_524674.1 Hexokinase_1 5..200 CDD:278764 102/186 (55%)
PTZ00107 13..454 CDD:240270 205/455 (45%)
Hexokinase_2 207..449 CDD:281689 98/258 (38%)
Hk2NP_038848.1 Mitochondrial-binding peptide (MBP). /evidence=ECO:0000250|UniProtKB:P52789 1..16
PTZ00107 12..460 CDD:240270 203/453 (45%)
Hexokinase_1 21..219 CDD:278764 103/187 (55%)
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 73..207 77/133 (58%)
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P52789 84..88 3/3 (100%)