DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and Hk1

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_030100764.1	Gene:	Hk1 / 15275	MGIID:	96103	Length:	997	Species:	Mus musculus

Alignment Length:	458	Identity:	187/458 - (40%)
Similarity:	287/458 - (62%)	Gaps:	22/458 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDL 69
            ::.|.:..|.||...:.||..:...|:..||::.|:.:|.||..|:||:.:|.|.|.|.:|||||
Mouse   548 QIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDL 612

  Fly    70 GGTNFRVLLVSLKGHHDATVD--SQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPL 132
            ||||||||||.::.....||:  ::||::|.::|.|.|.:|||||..|::.|::...:|...:||
Mouse   613 GGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPL 677

  Fly   133 GFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLM 197
            ||||||||.|..|..|||:.|||||......|.||..:|.:|::||.:.|:.|||::|||.||:|
Mouse   678 GFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMM 742

  Fly   198 SCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTE 262
            :||:....|.:|:|||||.||||:|:::||:::..:    :..:.:|.||||||:.|.||.:||:
Mouse   743 TCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEGN----QGQMCINMEWGAFGDNGCLDDIRTD 803

  Fly   263 YDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFE 327
            :|:.|||.|||..:|.||||.:|||||.:||.:|:...::..:|:.....|      .:...:||
Mouse   804 FDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEP------LKTRGIFE 862

  Fly   328 TRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRT 392
            |:::|:||.|.. .....|.|::.| || .::.:|...::.:|..|:||||.|...|::.:|.:.
Mouse   863 TKFLSQIESDRL-ALLQVRAILQQL-GL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKI 924

  Fly   393 SNRR------VIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVAS 451
            ...|      |.||:||::|:.||.|...|.||:::| ........:|||||||:||||:.||..
Mouse   925 RENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKEL-SPKCTVSFLLSEDGSGKGAALITAVGV 988

  Fly   452 KTK 454
            :.:
Mouse   989 RLR 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	88/196 (45%)
		PTZ00107	13..454	CDD:240270	186/448 (42%)
		Hexokinase_2	207..449	CDD:281689	94/247 (38%)
Hk1	XP_030100764.1	PTZ00107	75..539	CDD:240270
		Hexokinase_1	548..746	CDD:376323	89/197 (45%)
		Hexokinase_2	752..986	CDD:377112	94/247 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837014
Domainoid	1	1.000	208	1.000	Domainoid score	I2848
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100530
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8788
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.750