Protein Alignment Hex-C and Gck

DIOPT Version :9

• Sequence 1: NP_524674.1
• Gene: Hex-C / 44008
• FlyBaseID: FBgn0001187
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: XP_006514506.1
• Gene: Gck / 103988
• MGIID: 1270854
• Length: 487
• Species: Mus musculus
• Alignment Length: 418
• Identity: 187/418 - (44%)
• Similarity: 267/418 - (63%)
• Gaps: 27/418 - (6%)

  Fly     6 VRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLG 70
            |.:::..|.|.:..:::|.||...|:.||||..||.:|:||..||||:..|.|.|:|.:|:||||
Mouse    16 VEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLG 80

  Fly    71 GTNFRVLLVSL----KGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLP 131
            ||||||:||.:    .|........|:|::|:|.|.|....|||:|:.|::.|::||.||...||
Mouse    81 GTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLP 145

  Fly   132 LGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTL 196
            ||||||||.....:.:|||:.|||||..:|.||.::..:|.:||:||||.::.|||::|||..|:
Mouse   146 LGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATM 210

  Fly   197 MSCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRT 261
            :||.:.:..|.||:||||||||||:|:::||:|:..|    :..:.||.||||||..|:||....
Mouse   211 ISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGD----EGRMCVNTEWGAFGNSGELDEFLL 271

  Fly   262 EYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVF 326
            ||||.|||.|:|..:||:||:..|.|:|.|||||||:.:|..|:|...      ||...|....|
Mouse   272 EYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGE------ASEQLRTRGAF 330

  Fly   327 ETRYISEIEDDSFPEFASTRKIVKNL--FGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLV 389
            |||::|::|.||    ...|:|:..|  .|| :.||.||..:|..||.|:.|||.:.:.|::|::
Mouse   331 ETRFVSQVESDS----GDRRQILNILSTLGL-RPSVADCDIVRRACESVSTRAAHMCSAGLAGVI 390

  Fly   390 NRTSN------RRVIVGMDGSVYRYHPK 411
            ||...      .|:.||:|||||:.||:
Mouse   391 NRMRESRSEDVMRITVGVDGSVYKLHPR 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	90/197 (46%)
		PTZ00107	13..454	CDD:240270	186/411 (45%)
		Hexokinase_2	207..449	CDD:281689	95/213 (45%)
Gck	XP_006514506.1	COG5026	16..418	CDD:227359	186/416 (45%)
		Hexokinase_1	16..215	CDD:376323	91/198 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837013
Domainoid	1	1.000	208	1.000	Domainoid score	I2848
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1846
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8788
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.820