DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-C and LOC100493823

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_002936904.3	Gene:	LOC100493823 / 100493823	-ID:	-	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	459	Identity:	195/459 - (42%)
Similarity:	296/459 - (64%)	Gaps:	28/459 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDL 69
            ::.|::....||:..:.::..|..:|:..||.:.||..|.||..||:|...|.|.|.||:|||||
Frog   468 QIDEILALLQLSNENLFDIKERMMIELKNGLMKETHGSATVKMLPTFVYGTPDGTEWGKFLALDL 532

  Fly    70 GGTNFRVLLVSLKGHHDATVD--SQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPL 132
            ||||||||||.::......|.  ::|:|:|.::|.|.|.:|||||..|:|:|::...:|.|.|||
Frog   533 GGTNFRVLLVKIRSGRRKYVRMYNKIFAIPLEIMQGTGEELFDHIVECIAEFLDYMGIKGAPLPL 597

  Fly   133 GFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLM 197
            ||||||||.|..:.:|.||.|||||.....||:||..||.|||:||.:.|:.:|||:|||.||:|
Frog   598 GFTFSFPCKQERIDKGTLVGWTKGFKATDCEGQDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMM 662

  Fly   198 SCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTE 262
            :|.:.:.:|.:|:|.|||.|.||:|:::|::::..|..|    :.:|.|||.||:.|.|..::|:
Frog   663 TCGYEDPNCEIGLIAGTGSNVCYMEEMKNIEIVDGDEGK----MCINTEWGGFGDNGCLADIQTK 723

  Fly   263 YDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFK-QSSRRPEFASVLQRNEEVF 326
            ||.:|||||||..:|.:||||:|||||.:||.:|:...:..|:|: |.|.|       .|.:.:|
Frog   724 YDIDVDEKSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKCGLLFRGQISER-------LRTKGIF 781

  Fly   327 ETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNR 391
            ||:::|:||.|.. .....|||::.| ||: ::.:|...::.:|..|:.|||.|...|::.:|::
Frog   782 ETKFLSQIESDRL-ALLQVRKILQQL-GLD-STCDDSIIVKEVCGAVSTRAAKLCGAGLAAVVDK 843

  Fly   392 TSNRR------VIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDI--MLSEDGSGRGAALVAA 448
            ....|      |.||:||::|:.||.|...:::|::||   ..:.|:  ||||||||:||||:.|
Frog   844 IRENRDLEHLKVTVGVDGTLYKLHPHFSRILQETVKKL---SPQCDVTFMLSEDGSGKGAALITA 905

  Fly   449 VASK 452
            ||.:
Frog   906 VAKR 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	93/196 (47%)
		PTZ00107	13..454	CDD:240270	194/451 (43%)
		Hexokinase_2	207..449	CDD:281689	97/250 (39%)
LOC100493823	XP_002936904.3	Hexokinase_1	21..218	CDD:395278
		Hexokinase_2	224..458	CDD:397683
		Hexokinase_1	468..666	CDD:395278	94/197 (48%)
		Hexokinase_2	672..906	CDD:397683	97/250 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010