DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-C and hk2

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001120545.1	Gene:	hk2 / 100145699	XenbaseID:	XB-GENE-5817381	Length:	915	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	188/450 - (41%)
Similarity:	285/450 - (63%)	Gaps:	22/450 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLGGTNF 74
            :|||.||..|:..|.......:.|||.::....:.:|..||||:..|.|.|.|.:|.|||||..|
Frog    24 LQPFHLSQVQLLSVRDLMLANMERGLMKTPQKPSTLKMLPTYVRSTPDGTERGDFLVLDLGGAQF 88

  Fly    75 RVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFTFSFP 139
            |:|.|.||......::||:||:|.::|.|.|..||||:|.||.:|:.:..:....||||||||||
Frog    89 RILHVELKDSAKVEMESQVYAIPDEVMHGTGQQLFDHVAECLGRFLRQQKLHQKVLPLGFTFSFP 153

  Fly   140 CVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNA 204
            |||..|.:.:|:.|||||.|:.|||:||..:|.|||.|:||.::.|:||:|||.|.:|||.:::.
Frog   154 CVQSQLDKSVLISWTKGFHCSDVEGKDVVHLLREAICRQGDYEVDVIAIVNDTVGAMMSCGYQDH 218

  Fly   205 DCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDE 269
            .|.||.|||||.|.||:|::.||:.:..|..|    :.:|.||||.|:.|:|..::||.|:::|:
Frog   219 SCEVGFIVGTGTNLCYMEEMGNVESVEGDEGK----MCINTEWGALGDDGELSSIQTEIDKQLDQ 279

  Fly   270 KSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRYISEI 334
            .||...:|.|:|:.:|||:|.:|||:|::...:.|:|..::.:    ::|.:.  .|||:::|.|
Frog   280 NSLVSGKQCFDKLVSGMYMGEIVRLILVKLANQGLLFDGTTTQ----ALLSKG--CFETKHVSAI 338

  Fly   335 EDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTS------ 393
            ||| ....:|.|||: ::.|| ..|.:||..::.:|..|:.|:|.|.|.|::.:..|..
Frog   339 EDD-HSGLSSARKIL-SVLGL-NPSEQDCVNVQQVCSAVSTRSANLCAAGLAAVAARLQCNSQDP 400

  Fly   394 NRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADK-EWDIMLSEDGSGRGAALVAAVASK 452
            ||::.:|:|||||:.||||...:...||.|  |.| :.:.::||||||:|.|:|.|||.:
Frog   401 NRKITIGVDGSVYKQHPKFSQRLHSALQHL--APKCQINFLISEDGSGKGTAIVTAVAKR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	89/189 (47%)
		PTZ00107	13..454	CDD:240270	186/446 (42%)
		Hexokinase_2	207..449	CDD:281689	94/248 (38%)
hk2	NP_001120545.1	Hexokinase_1	19..215	CDD:278764	90/190 (47%)
		PTZ00107	27..456	CDD:240270	184/443 (42%)
		Hexokinase_2	221..455	CDD:281689	94/248 (38%)
		PTZ00107	462..904	CDD:240270
		Hexokinase_1	465..663	CDD:278764
		Hexokinase_2	669..903	CDD:281689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	1	1.100	-	-	O	PTHR19443
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110