DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and gck

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_012813876.1	Gene:	gck / 100124905	XenbaseID:	XB-GENE-981992	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	204/474 - (43%)
Similarity:	301/474 - (63%)	Gaps:	38/474 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLD-------AEVRELMQPFVLSDYQVQE-----VYSRFCLEVARGLKRSTHPQANVKCFPTYVQ 53
            |||       .:::::.|  :||::.:||     :..|...|:.|||...|:.:|:||..||||:
Frog     1 MLDIKNKMEATQIQKVDQ--ILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVR 63

  Fly    54 DLPTGDEMGKYLALDLGGTNFRVLLV----SLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAG 114
            ..|.|.|:|.:||||||||||||:||    .|:|........::|::|:|.|.|....|||:||.
Frog    64 STPDGSEVGDFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPEDAMTGTAEMLFDYIAE 128

  Fly   115 CLAKFVEKHDMKTAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRG 179
            |::.::::.:||...||||||||||.....:.:|||:.|||||..:|.||.:|..:|.:||:|||
Frog   129 CISDYLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193

  Fly   180 DADIAVVAILNDTTGTLMSCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVN 244
            |.::.|||::|||..|::||.:.:..|.||:||||||||||:|::.||:|:..:    :..:.||
Frog   194 DFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGE----EGRMCVN 254

  Fly   245 AEWGAFGEGGQLDFVRTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQS 309
            .||||||:.|:|:..|.||||.|||.|||..:||:|||..|.|:|.||||||::.:...|||...
Frog   255 TEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENLIFGGE 319

  Fly   310 SRRPEFASVLQRNEEVFETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVA 374
            |      |...:....|:|:::|:||.|: .:|..|..|::.| |:: |::.||..:|..||.|:
Frog   320 S------SEKLKTRGAFDTQFVSQIEADT-SDFKQTLNILRTL-GVQ-ATIGDCHAVRLACESVS 375

  Fly   375 KRAATLVAIGVSGLVNR--TSNR----RVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIM 433
            .|||.:.:.|::.::||  .|.|    |:.||:|||||:.||.|......|:.||. :..|...:
Frog   376 TRAAVMCSSGLAAILNRMHQSRRGELSRITVGVDGSVYKLHPSFKDKFHATVHKLT-SGCEITFI 439

  Fly   434 LSEDGSGRGAALVAAVASK 452
            .||:||||||||::|||.|
Frog   440 QSEEGSGRGAALISAVAYK 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	88/203 (43%)
		PTZ00107	13..454	CDD:240270	200/455 (44%)
		Hexokinase_2	207..449	CDD:281689	107/247 (43%)
gck	XP_012813876.1	COG5026	6..458	CDD:227359	200/467 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1803
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060